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View article: Multiomic correlates of ex vivo αCD19 chimeric antigen receptor T-cell (CART) cytotoxicity in venetoclax-treated patients with chronic lymphocytic leukemia (CLL)
Multiomic correlates of ex vivo αCD19 chimeric antigen receptor T-cell (CART) cytotoxicity in venetoclax-treated patients with chronic lymphocytic leukemia (CLL) Open
Introduction: Chronic Lymphocytic Leukemia (CLL) results in the expansion of immunosuppressive B-cells leading to risk for secondary malignancies, infection, and suboptimal T-cell based immunotherapeutic responses. Treatments that restore …
View article: Evaluating the Benefits and Challenges of Using Patient Preferences as a Tool for Clinical Decision Making in Oncology Multidisciplinary Team Meetings within the National Health Service: A Qualitative Study
Evaluating the Benefits and Challenges of Using Patient Preferences as a Tool for Clinical Decision Making in Oncology Multidisciplinary Team Meetings within the National Health Service: A Qualitative Study Open
Introduction: Multidisciplinary team (MDT) oncology meetings foster collaboration among healthcare practitioners to determine the most appropriate course of action for cancer patient care. Defining what is “best” for a patient is complex, …
View article: Framework for implementing asylum seekers and refugees’ health into the undergraduate medical curriculum in the United Kingdom
Framework for implementing asylum seekers and refugees’ health into the undergraduate medical curriculum in the United Kingdom Open
The Ukrainian conflict and the increasing number of asylum seekers and refugees (AS&Rs) in the United Kingdom have highlighted the critical need for a dedicated AS&R health curriculum in medical undergraduate programmes. This study utilize…
View article: Review of: "The Support and Rehabilitation of Refugees – Personal Opinion and Experience"
Review of: "The Support and Rehabilitation of Refugees – Personal Opinion and Experience" Open
This article explores the impact that conflict and displacement have on refugees taking inspiration from Warsan Shires poem 'Home.'The author shares their experiences of working with refugees in countries including Syria, Iraq, Kenya, Sout…
View article: An Exploration of The Lived Experience of Informal Student Carers During Covid-19
An Exploration of The Lived Experience of Informal Student Carers During Covid-19 Open
Informal Student Carers (ISC) are students who provide unpaid care to a friend or family member needing support. We explored the lived experiences of ISC and the challenges they faced throughout the Covid-19 pandemic. A scoping review, que…
View article: #5863 A NOVEL SELF-SEALING DIALYSIS PORT EVALUATION
#5863 A NOVEL SELF-SEALING DIALYSIS PORT EVALUATION Open
Background and Aims There are several complications associated with hemodialytic vascular that arise from the incorrect cannulation, including aneurysms, infection, vessel damage, and uncontrolled bleeding. These risks severely limit treat…
View article: The need for inclusion of integrated teaching on refugee and asylum seeker health in undergraduate medical curriculum
The need for inclusion of integrated teaching on refugee and asylum seeker health in undergraduate medical curriculum Open
Introduction Providing care for refugees and asylum seekers requires special knowledge and training. Refugees and asylum seekers often have unique health needs that require specialized care. Purpose This research focused on the need and re…
View article: Supplemental Tables 1 through 3 from mTORC2 Signaling Drives the Development and Progression of Pancreatic Cancer
Supplemental Tables 1 through 3 from mTORC2 Signaling Drives the Development and Progression of Pancreatic Cancer Open
Table S1: Antibodies for immunohistochemistry. Table S2: shRNA sequences. Table S3: Antibodies for western blotting.
View article: Data from mTORC2 Signaling Drives the Development and Progression of Pancreatic Cancer
Data from mTORC2 Signaling Drives the Development and Progression of Pancreatic Cancer Open
mTOR signaling controls several critical cellular functions and is deregulated in many cancers, including pancreatic cancer. To date, most efforts have focused on inhibiting the mTORC1 complex. However, clinical trials of mTORC1 inhibitors…
View article: Data from mTORC2 Signaling Drives the Development and Progression of Pancreatic Cancer
Data from mTORC2 Signaling Drives the Development and Progression of Pancreatic Cancer Open
mTOR signaling controls several critical cellular functions and is deregulated in many cancers, including pancreatic cancer. To date, most efforts have focused on inhibiting the mTORC1 complex. However, clinical trials of mTORC1 inhibitors…
View article: Supplemental Tables 1 through 3 from mTORC2 Signaling Drives the Development and Progression of Pancreatic Cancer
Supplemental Tables 1 through 3 from mTORC2 Signaling Drives the Development and Progression of Pancreatic Cancer Open
Table S1: Antibodies for immunohistochemistry. Table S2: shRNA sequences. Table S3: Antibodies for western blotting.
View article: Supplemental Figures 1 through 8 from mTORC2 Signaling Drives the Development and Progression of Pancreatic Cancer
Supplemental Figures 1 through 8 from mTORC2 Signaling Drives the Development and Progression of Pancreatic Cancer Open
Figure S1: Loss of Rictor does not prevent pancreatic formation or function. Figure S2: Rictor deletion decreases proliferation in PanIN1 lesions. Figure S3: Rictor deletion alters CDKI and BMI1 expression and localization. Figure S4: Rict…
View article: Supplemental Figure Legends from mTORC2 Signaling Drives the Development and Progression of Pancreatic Cancer
Supplemental Figure Legends from mTORC2 Signaling Drives the Development and Progression of Pancreatic Cancer Open
Supplementary figure legends for Figures S1-S8
View article: Supplemental Figure Legends from mTORC2 Signaling Drives the Development and Progression of Pancreatic Cancer
Supplemental Figure Legends from mTORC2 Signaling Drives the Development and Progression of Pancreatic Cancer Open
Supplementary figure legends for Figures S1-S8
View article: Supplemental Methods from mTORC2 Signaling Drives the Development and Progression of Pancreatic Cancer
Supplemental Methods from mTORC2 Signaling Drives the Development and Progression of Pancreatic Cancer Open
Supplementary materials and methods
View article: Supplemental Figures 1 through 8 from mTORC2 Signaling Drives the Development and Progression of Pancreatic Cancer
Supplemental Figures 1 through 8 from mTORC2 Signaling Drives the Development and Progression of Pancreatic Cancer Open
Figure S1: Loss of Rictor does not prevent pancreatic formation or function. Figure S2: Rictor deletion decreases proliferation in PanIN1 lesions. Figure S3: Rictor deletion alters CDKI and BMI1 expression and localization. Figure S4: Rict…
View article: Supplemental Methods from mTORC2 Signaling Drives the Development and Progression of Pancreatic Cancer
Supplemental Methods from mTORC2 Signaling Drives the Development and Progression of Pancreatic Cancer Open
Supplementary materials and methods
View article: Lived experiences of black women pursuing STEM in UK higher education
Lived experiences of black women pursuing STEM in UK higher education Open
Black students and researchers in higher education (HE) face scarcity of relatable role models in STEM subjects. Black women are under-represented in STEM and their outlook is under-researched. We undertook this project to understand the p…
View article: Inter‐ethnic differences in pharmacokinetics—is there more that unites than divides?
Inter‐ethnic differences in pharmacokinetics—is there more that unites than divides? Open
Inter‐ethnic variability in pharmacokinetics (PK) has been attributed to several factors ranging from genetic to environmental. It is not clear how current teaching in higher education (HE) reflects what published literature suggests on th…
View article: Human R1441C LRRK2 regulates the synaptic vesicle proteome and phosphoproteome in a<i>Drosophila</i>model of Parkinson’s disease
Human R1441C LRRK2 regulates the synaptic vesicle proteome and phosphoproteome in a<i>Drosophila</i>model of Parkinson’s disease Open
Mutations in leucine-rich repeat kinase 2 (LRRK2) cause late-onset, autosomal dominant familial Parkinson`s disease (PD) and variation at the LRRK2 locus contributes to the risk for idiopathic PD. LRRK2 can function as a protein kinase and…
View article: mTORC2 Signaling Drives the Development and Progression of Pancreatic Cancer
mTORC2 Signaling Drives the Development and Progression of Pancreatic Cancer Open
mTOR signaling controls several critical cellular functions and is deregulated in many cancers, including pancreatic cancer. To date, most efforts have focused on inhibiting the mTORC1 complex. However, clinical trials of mTORC1 inhibitors…
View article: Identification of protein phosphatase 2A as an interacting protein of leucine-rich repeat kinase 2
Identification of protein phosphatase 2A as an interacting protein of leucine-rich repeat kinase 2 Open
Mutations in the gene coding for the multi-domain protein leucine-rich repeat kinase 2 (LRRK2) are the leading cause of genetically inherited Parkinson’s disease (PD). Two of the common found mutations are the R1441C and G2019S. In this st…
View article: Direct Sensing of Nutrients via a LAT1-like Transporter in Drosophila Insulin-Producing Cells.
Direct Sensing of Nutrients via a LAT1-like Transporter in Drosophila Insulin-Producing Cells. Open
Dietary leucine has been suspected to play an important role in insulin release, a hormone that controls satiety and metabolism. The mechanism by which insulin-producing cells (IPCs) sense leucine and regulate insulin secretion is still po…