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View article: High Copy Number Variations Correlate with a Pro-Tumoral Microenvironment and Worse Prognosis in Acral Lentiginous Melanoma
High Copy Number Variations Correlate with a Pro-Tumoral Microenvironment and Worse Prognosis in Acral Lentiginous Melanoma Open
Acral lentiginous melanoma (ALM) is a rare melanoma subtype primarily located in acral regions. However, ALMs exhibit a distinctive genetic profile characterized by a high number of copy number variations (CNVs) and limited point mutations…
View article: Effect of consumption of anthocyanin-rich products on NMR lipoprotein subclasses and biomarkers in hypercholesterolemic subjects: a randomized controlled trial (the AppleCOR study)
Effect of consumption of anthocyanin-rich products on NMR lipoprotein subclasses and biomarkers in hypercholesterolemic subjects: a randomized controlled trial (the AppleCOR study) Open
Anthocyanin-rich products (RFA and AI) decreased LDLc; ApoB; total, large, and small LDL-P; LDL size; TG/HDL ratio, large TRL, and GlycA and alanine versus WFA. Thus, anthocyanin-rich products provided greater protection against CVD risk t…
View article: Advances in Immunotherapy for Endometrial Cancer: Insights into MMR Status and Tumor Microenvironment
Advances in Immunotherapy for Endometrial Cancer: Insights into MMR Status and Tumor Microenvironment Open
Endometrial cancer is one of the most common gynecological malignancies, and while early-stage cases are highly treatable, recurrent or advanced EC remains challenging to manage. Immunotherapy, particularly immune checkpoint inhibitors, ha…
View article: Metabolomic-Based Approaches for Endometrial Cancer Diagnosis and Prognosis: A Review
Metabolomic-Based Approaches for Endometrial Cancer Diagnosis and Prognosis: A Review Open
Endometrial cancer, the most prevalent gynecological malignancy in developed countries, is experiencing a sustained rise in both its incidence and mortality rates, primarily attributed to extended life expectancy and lifestyle factors. Cur…
View article: Protocol to characterize the melanoma tumor immune microenvironment in mice from single cell to flow cytometry analysis
Protocol to characterize the melanoma tumor immune microenvironment in mice from single cell to flow cytometry analysis Open
Here, we present a protocol to study and describe immune cells that surround or infiltrate tumor cells or get through the body of a melanoma syngeneic mice model. We describe steps for creating and establishing the syngeneic mouse model, e…
View article: Molecular Profile of Subungual Melanoma: A MelaNostrum Consortium Study of 68 Cases Reporting BRAF, NRAS, KIT, and TERT Promoter Status
Molecular Profile of Subungual Melanoma: A MelaNostrum Consortium Study of 68 Cases Reporting BRAF, NRAS, KIT, and TERT Promoter Status Open
Background: Subungual melanoma (SM) is an unusual type of melanocytic tumor affecting the nail apparatus. The mutational prevalence of the most prominently mutated genes in melanoma has been reported in small cohorts of SM, with unclear co…
View article: Supplementary Material for: Molecular Profile of Subungual Melanoma: a MelaNostrum Consortium Study of 68 Cases Reporting BRAF, NRAS, KIT, and TERT promoter status.
Supplementary Material for: Molecular Profile of Subungual Melanoma: a MelaNostrum Consortium Study of 68 Cases Reporting BRAF, NRAS, KIT, and TERT promoter status. Open
Background: Subungual melanoma (SM) is an unusual type of melanocytic tumor affecting the nail apparatus. The mutational prevalence of the most prominently mutated genes in melanoma has been reported in small cohorts of SM, with unclear co…
View article: A dominant negative mutation uncovers cooperative control of caudal Wolffian duct development by Sprouty genes
A dominant negative mutation uncovers cooperative control of caudal Wolffian duct development by Sprouty genes Open
The Wolffian ducts (WD) are paired epithelial tubules central to the development of the mammalian genitourinary tract. Outgrowths from the WD known as the ureteric buds (UB) generate the collecting ducts of the kidney. Later during develop…
View article: A dominant negative mutation uncovers cooperative control of caudal Wolffian Duct development by Sprouty genes
A dominant negative mutation uncovers cooperative control of caudal Wolffian Duct development by Sprouty genes Open
The Wolffian Ducts (WD) are paired epithelial tubules central to the development of the mammalian genitourinary tract. Outgrowths from the WD known as the ureteric buds (UB) generate the collecting ducts of the kidney. Later during develop…
View article: <i>ARID1A</i> ‐deficient cells require HDAC6 for progression of endometrial carcinoma
<i>ARID1A</i> ‐deficient cells require HDAC6 for progression of endometrial carcinoma Open
AT‐rich interactive domain‐containing protein 1A (ARID1A) loss‐of‐function mutation accompanied by a loss of ARID1A protein expression is frequently observed in endometrial carcinomas. However, the molecular mechanisms linking these geneti…
View article: Differential Immunoexpression of BRAF/V600E, Senescence Markers, PTEN, and T-type Calcium Channels in Acquired Naevi According to their Histopathological and Dermoscopic Classification
Differential Immunoexpression of BRAF/V600E, Senescence Markers, PTEN, and T-type Calcium Channels in Acquired Naevi According to their Histopathological and Dermoscopic Classification Open
BRAF/V600E mutation and other cell growth/growth-control mechanisms are involved in naevogenesis and melanomagenesis. Immunoexpression of BRAF/V600E and other molecules (p16, phosphatase and tensin homologue (PTEN), Ki67, hTERT and Cav3.1 …
View article: BRAFV600E Mutant Allele Frequency (MAF) Influences Melanoma Clinicopathologic Characteristics
BRAFV600E Mutant Allele Frequency (MAF) Influences Melanoma Clinicopathologic Characteristics Open
Background: Cutaneous melanoma shows high variability regarding clinicopathological presentation, evolution and prognosis. Methods: Next generation sequencing was performed to analyze hotspot mutations in different areas of primary melanom…
View article: Berry fruits modulate kidney dysfunction and urine metabolome in Dahl salt-sensitive rats
Berry fruits modulate kidney dysfunction and urine metabolome in Dahl salt-sensitive rats Open
Berries are rich sources of (poly)phenols which have been associated with the prevention of cardiovascular diseases in animal models and in human clinical trials. Recently, a berry enriched diet was reported to decrease blood pressure and …
View article: T-Type Calcium Channels: A Potential Novel Target in Melanoma
T-Type Calcium Channels: A Potential Novel Target in Melanoma Open
T-type calcium channels (TTCCs) are overexpressed in several cancers. In this review, we summarize the recent advances and new insights into TTCC biology, tumor progression, and prognosis biomarker and therapeutic potential in the melanoma…
View article: In vitro Cell Migration, Invasion, and Adhesion Assays: From Cell Imaging to Data Analysis
In vitro Cell Migration, Invasion, and Adhesion Assays: From Cell Imaging to Data Analysis Open
Cell migration is a key procedure involved in many biological processes including embryological development, tissue formation, immune defense or inflammation, and cancer progression. How physical, chemical, and molecular aspects can affect…
View article: T‐type calcium channels drive migration/invasion in <scp>BRAFV</scp>600E melanoma cells through Snail1
T‐type calcium channels drive migration/invasion in <span>BRAFV</span>600E melanoma cells through Snail1 Open
Summary Melanoma is a malignant tumor derived from melanocytes. Once disseminated, it is usually highly resistant to chemotherapy and is associated with poor prognosis. We have recently reported that T‐type calcium channels ( TTCC s) are o…
View article: Inhibition of WNT-CTNNB1 signaling upregulates SQSTM1 and sensitizes glioblastoma cells to autophagy blockers
Inhibition of WNT-CTNNB1 signaling upregulates SQSTM1 and sensitizes glioblastoma cells to autophagy blockers Open
WNT-CTNN1B signaling promotes cancer cell proliferation and stemness. Furthermore, recent evidence indicates that macroautophagy/autophagy regulates WNT signaling. Here we investigated the impact of inhibiting WNT signaling on autophagy in…
View article: Corrigendum to “Calcium Channel Expression and Applicability as Targeted Therapies in Melanoma”
Corrigendum to “Calcium Channel Expression and Applicability as Targeted Therapies in Melanoma” Open
[This corrects the article DOI: 10.1155/2015/587135.].
View article: Sprouty1 haploinsufficiency accelerates pheochromocytoma development in Pten+/− mice
Sprouty1 haploinsufficiency accelerates pheochromocytoma development in Pten+/− mice Open
Pheochromocytomas (PCCs) are rare catecholamine-secreting tumors arising from the chromaffin cells in the adrenal medulla. Closely related paragangliomas share developmental origin but arise extra-adrenally, in the paraganglia that belongs…
View article: Calcium Channel Expression and Applicability as Targeted Therapies in Melanoma
Calcium Channel Expression and Applicability as Targeted Therapies in Melanoma Open
The remodeling of Ca 2+ signaling is a common finding in cancer pathophysiology serving the purpose of facilitating proliferation, migration, or survival of cancer cells subjected to stressful conditions. One particular facet of these adap…