Anna A. Manchenko
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View article: Antibodies disrupt bacterial adhesion by ligand mimicry and allosteric interference
Antibodies disrupt bacterial adhesion by ligand mimicry and allosteric interference Open
A critical step in infections is the attachment of microorganisms to host cells using lectins that bind glycans, making lectins promising antimicrobial targets. Upon binding mannosylated glycans, FimH, an adhesin in E. coli, undergoes an a…
View article: <i>De Novo</i> Design of Miniprotein Inhibitors of Bacterial Adhesins
<i>De Novo</i> Design of Miniprotein Inhibitors of Bacterial Adhesins Open
The rise of multidrug-resistant bacterial infections necessitates the discovery of novel antimicrobial strategies. Here, we show that protein design provides a generalizable means of generating new antimicrobials by neutralizing the functi…
View article: EFFECT OF CRYOPRESERVED PLACENTA EXTRACT ON SOME BIOCHEMICAL INDICES OF THERAPEUTIC EFFICIENCY AND TOXICITY OF DICLOFENAC SODIUM IN ADJUVANT-INDUCED EXPERIMENTAL ARTHRITIS
EFFECT OF CRYOPRESERVED PLACENTA EXTRACT ON SOME BIOCHEMICAL INDICES OF THERAPEUTIC EFFICIENCY AND TOXICITY OF DICLOFENAC SODIUM IN ADJUVANT-INDUCED EXPERIMENTAL ARTHRITIS Open
Non-steroidal anti-inflammatory drugs are among the top requested ones in the clinic of internal medicine. However, these drugs are associated with a wide range of adverse reactions involving a number of organs and systems, in particular t…
View article: Doppler examination of aorta after therapeutic hypothermia and administering MSCs in experimental myocardial infarction
Doppler examination of aorta after therapeutic hypothermia and administering MSCs in experimental myocardial infarction Open
Background. At present, there are attempts aimed at repairing the myocardium affected by acute myocardial infarction (MI) via biologically sourced drugs, which are able to stimulate reparative regeneration, including the use of mesenchymal…
View article: Ultrasound assessment of heart remodelling affected by therapeutic hypothermia and MSC on myocardial infarction model
Ultrasound assessment of heart remodelling affected by therapeutic hypothermia and MSC on myocardial infarction model Open
Background. Late seeking medical advice, limited number of cardiac surgery hospitals and conservative treatment, which does not seem to be always efficacious, trigger the search for new, more effective mode therapy of acute myocardial infa…
View article: Morphology of tissue reaction in rats after subcutaneous implantation of porcine pericardium and aortic valve leaflets devitalized by cryoradiation
Morphology of tissue reaction in rats after subcutaneous implantation of porcine pericardium and aortic valve leaflets devitalized by cryoradiation Open
The decrease of immunogenicity is a priority requirement to pre-implantation treatment of the xenogeneic graft tissue. To create tissue implants of the pericardium and aortic valve leaflets, we have developed a method of devitalizing treat…