Annamaria Ferrero
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View article: PARPi and myeloid neoplasms; the Italian MITO-MaNGO experience based on a multicentric survey
PARPi and myeloid neoplasms; the Italian MITO-MaNGO experience based on a multicentric survey Open
While this survey is meant as hypotheses-generating, PrMN represent a rare but clinically relevant complication, particularly uncommon when PARPi are administered as first-line therapy. Their occurrence does not appear to be associated wit…
View article: European training requirements for gynecological oncology: the European Society of Gynaecological Oncology Curriculum
European training requirements for gynecological oncology: the European Society of Gynaecological Oncology Curriculum Open
View article: 85P Niraparib customized dosing regimen (RADAR) to manage thrombocytopenia events in platinum-sensitive recurrent ovarian cancer patients: The NEWTON trial
85P Niraparib customized dosing regimen (RADAR) to manage thrombocytopenia events in platinum-sensitive recurrent ovarian cancer patients: The NEWTON trial Open
View article: Comparative Study of Mastectomy Surgical Techniques Followed by Reconstruction: Hydrodissection and Electrical Plasma Surgery
Comparative Study of Mastectomy Surgical Techniques Followed by Reconstruction: Hydrodissection and Electrical Plasma Surgery Open
Background/Objectives: Mastectomy is a surgical option for breast cancer when conservative treatment is unsuitable, and it is also performed prophylactically in high-risk women. Various surgical techniques can be used for mastectomy, inclu…
View article: Assessment of the Efficacy and Safety of a Dual-Wavelength Diode Laser System for the Treatment of Vulvovaginal Atrophy in Women Without a History of Breast Cancer and in Patients with a History of Breast Cancer
Assessment of the Efficacy and Safety of a Dual-Wavelength Diode Laser System for the Treatment of Vulvovaginal Atrophy in Women Without a History of Breast Cancer and in Patients with a History of Breast Cancer Open
Background/Objectives: Vaginal laser therapy is a promising treatment for menopausal vulvovaginal atrophy (VVA). This study evaluates the efficacy of a dual-wavelength diode laser (980 + 1470 nm) in treating VVA. Methods: Thirty postmenopa…
View article: Lower Airway Diseases in the Paediatric Population: A Two-Year, Single-Centre, Retrospective Study
Lower Airway Diseases in the Paediatric Population: A Two-Year, Single-Centre, Retrospective Study Open
Background: Lower airway diseases in children are one of the major causes of hospitalisation. This study aimed to evaluate the characteristics of children admitted to a tertiary pediatric hospital diagnosed with lower airway disease and to…
View article: Impact of metabolism-related markers on outcomes in ovarian cancer patients: Findings of the MITO16A/MaNGO-OV2 trial
Impact of metabolism-related markers on outcomes in ovarian cancer patients: Findings of the MITO16A/MaNGO-OV2 trial Open
Introduction In ovarian cancer, expression of metabolism-related markers has been investigated in several studies focusing on individual markers; however, a parallel quantitative evaluation of markers mapping to distinct metabolic processe…
View article: SENECA study: staging endometrial cancer based on molecular classification
SENECA study: staging endometrial cancer based on molecular classification Open
View article: Real-life clinical benefit of oral metronomic cyclophosphamide administration in elderly and heavily pretreated epithelial ovarian cancer patients
Real-life clinical benefit of oral metronomic cyclophosphamide administration in elderly and heavily pretreated epithelial ovarian cancer patients Open
Purpose Oral metronomic cyclophosphamide (OMC) implicates the daily administration of low doses of chemotherapy. Its antitumor activity combined with an oral administration route and a good toxicity profile makes OMC an attractive option f…
View article: New Frontiers in Locally Advanced Cervical Cancer Treatment
New Frontiers in Locally Advanced Cervical Cancer Treatment Open
Despite the introduction of targeted vaccines and screening protocols, locally advanced cervical cancer represents a median proportion of 37% among all cervical carcinomas. Compared to early stages, it presents significantly lower cure rat…
View article: Induction of labour with cervical ripening balloon associated with oral misoprostol: an observational study comparing sequential and concurrent administration
Induction of labour with cervical ripening balloon associated with oral misoprostol: an observational study comparing sequential and concurrent administration Open
Purpose. The association of cervical ripening balloons (CRB) and misoprostol for induction of labour (IoL) is frequently used, although there is poor evidence about the optimal timing and protocol for their combination. The aim of this stu…
View article: PARP Inhibitors in Brain Metastases from Epithelial Ovarian Cancer through a Multimodal Patient Journey: Case Reports and Literature Review
PARP Inhibitors in Brain Metastases from Epithelial Ovarian Cancer through a Multimodal Patient Journey: Case Reports and Literature Review Open
Epithelial ovarian cancer (EOC) is the deadliest gynecological malignancy worldwide. Brain metastasis (BM) is quite an uncommon presentation. However, the likelihood of central nervous system (CNS) metastasization should be considered in t…
View article: PARP Inhibitors in Brain Metastases from Epithelial Ovarian Cancer Through a Multimodal Patient Journey: Case Reports and Literature Review.
PARP Inhibitors in Brain Metastases from Epithelial Ovarian Cancer Through a Multimodal Patient Journey: Case Reports and Literature Review. Open
Background. Epithelial ovarian cancer (EOC) is the deadliest gynecological malignancy worldwide. Brain metastasis (BM) is quite an uncommon presentation. However, the likelihood of central nervous system (CNS) metastasization should be con…
View article: 66P PARPi and myeloid neoplasia: The Italian MITO-MaNGO experience based on a multicentric survey
66P PARPi and myeloid neoplasia: The Italian MITO-MaNGO experience based on a multicentric survey Open
The risk of PARPi related myeloid neoplasias (PrMN) in PARPi treated patients has been a growing concern. Morice's metanalyses, taking into consideration the trials and the World Health Organization (WHO) Vigibase, has shown a significant …
View article: Metabolic coordination and phase transitions in spatially distributed multi-cellular systems
Metabolic coordination and phase transitions in spatially distributed multi-cellular systems Open
During overflow metabolism, cells excrete glycolytic byproducts when growing under aerobic conditions in a seemingly wasteful fashion. While potentially advantageous for microbes with finite oxidative capacity, its role in higher organisms…
View article: A prospective, multicenter, randomized, double-blind placebo-controlled trial on purified and specific Cytoplasmic pollen extract for hot flashes in breast cancer survivors
A prospective, multicenter, randomized, double-blind placebo-controlled trial on purified and specific Cytoplasmic pollen extract for hot flashes in breast cancer survivors Open
PureCyTonin significantly reduces HF number after 3 months of therapy in BCS and it is well-tolerated.
View article: Impact of Pregnancy on Breast Cancer Features and Prognosis
Impact of Pregnancy on Breast Cancer Features and Prognosis Open
Background: pregnancy-associated breast cancer (PABC) affects one in 3000 pregnancies, often presenting with aggressive features. Methods: We retrospectively evaluated a cohort of 282 young BC patients (≤45 years old) treated between 1995 …
View article: Hormone Replacement Therapy in Post-Menopause Hormone-Dependent Gynecological Cancer Patients: A Narrative Review
Hormone Replacement Therapy in Post-Menopause Hormone-Dependent Gynecological Cancer Patients: A Narrative Review Open
Background. Advances in the treatment of gynecological cancer have led to improvements in survival but also an increase in menopausal symptoms, especially in young women with premature iatrogenic menopause. Methods. A narrative review was …
View article: Adoption of electronic patient-reported outcomes in cancer clinical practice: the point of view of Italian patients
Adoption of electronic patient-reported outcomes in cancer clinical practice: the point of view of Italian patients Open
Background: In 2022, the European Society for Medical Oncology (ESMO) guideline recommended the adoption of electronic patient-reported outcomes measures (ePROMs) in routine clinical practice for patients with cancer. The aim of this surve…
View article: Impact of different follow-up regimens on health-related quality of life and costs in endometrial cancer patients: Results from the TOTEM randomized trial
Impact of different follow-up regimens on health-related quality of life and costs in endometrial cancer patients: Results from the TOTEM randomized trial Open
In the follow-up of endometrial cancer after surgery, a minimalist treatment regimen did not affect quality of life and was cost-saving in both low-risk and high-risk recurrence patients. As previous results showed no survival benefit, a m…
View article: SUCCOR morbidity: complications in minimally invasive versus open radical hysterectomy in early cervical cancer
SUCCOR morbidity: complications in minimally invasive versus open radical hysterectomy in early cervical cancer Open
View article: P564 Surgical treatment of jejuno-ileal Crohn’s disease. Results from the The JejUno Ileal Crohn's disEase (JUICE) international, multicentric, observational study
P564 Surgical treatment of jejuno-ileal Crohn’s disease. Results from the The JejUno Ileal Crohn's disEase (JUICE) international, multicentric, observational study Open
Background Crohn’s disease (CD) affecting the upper gastrointestinal (GI) tract is a rare condition, leading to a scarcity of information regarding its diagnosis, surgical treatment, and adjuvant therapy. The JUICE study aimed to conduct a…
View article: Minimally invasive liver resection versus transarterial chemoembolization for intermediate stage (BCLC-B) hepatocellular carcinoma: a propensity score analysis for long term survival in multicentric comparative study
Minimally invasive liver resection versus transarterial chemoembolization for intermediate stage (BCLC-B) hepatocellular carcinoma: a propensity score analysis for long term survival in multicentric comparative study Open
View article: Discordance between GCIG CA-125 progression and RECIST progression in the CALYPSO trial of patients with platinum-sensitive recurrent ovarian cancer
Discordance between GCIG CA-125 progression and RECIST progression in the CALYPSO trial of patients with platinum-sensitive recurrent ovarian cancer Open
Background CA-125 alone is widely used to diagnose progressive disease (PD) in platinum-sensitive recurrent ovarian cancer (PSROC) on chemotherapy. However, there are increasing concerns regarding its accuracy. We assessed concordance betw…
View article: The Prognostic Value of the Circulating-Tumor DNA in High-Grade Serous Epithelial Ovarian Cancer: Experience From MITO-16a/MANGO-OV2a/ Clinical Trial
The Prognostic Value of the Circulating-Tumor DNA in High-Grade Serous Epithelial Ovarian Cancer: Experience From MITO-16a/MANGO-OV2a/ Clinical Trial Open
View article: Ultrasonographic diagnosis of adnexal masses: interobserver agreement in the interpretation of videos, using IOTA terminology
Ultrasonographic diagnosis of adnexal masses: interobserver agreement in the interpretation of videos, using IOTA terminology Open
View article: LBA40 Phase III double-blind randomized placebo controlled trial of atezolizumab in combination with carboplatin and paclitaxel in women with advanced/recurrent endometrial carcinoma
LBA40 Phase III double-blind randomized placebo controlled trial of atezolizumab in combination with carboplatin and paclitaxel in women with advanced/recurrent endometrial carcinoma Open
View article: Factors associated with adherence to BRCA1/2 mutation testing after oncogenetic counseling in long-surviving patients with a previous diagnosis of breast or ovarian cancer
Factors associated with adherence to BRCA1/2 mutation testing after oncogenetic counseling in long-surviving patients with a previous diagnosis of breast or ovarian cancer Open
BRCA1/2 mutations account for 5 to 10% of breast and 15% of ovarian cancers. Various guidelines on BRCA1/2 genetic counseling and testing have been issued, and the criteria have evolved over the years. Oncogenetic counseling aims to inform…
View article: #564 Role of nodal staging in the management of adjuvant treatment in high intermediate risk (HIR) and high risk (HR) endometrial cancer
#564 Role of nodal staging in the management of adjuvant treatment in high intermediate risk (HIR) and high risk (HR) endometrial cancer Open
Introduction/Background In 2020 ESGO/ESTRO/ESP guidelines sentinel lymph node biopsy (SLNB) has been introduced as an alternative to lymph node dissection (LND). A negative SLN is accepted to confirm pN0, has prognostic significance but ev…
View article: #884 Loco-regional treatment of oligometastatic recurrence in patients with epithelial ovarian cancer: comparison between radiotherapy and surgery
#884 Loco-regional treatment of oligometastatic recurrence in patients with epithelial ovarian cancer: comparison between radiotherapy and surgery Open
Introduction/Background Systemic therapy is the standard treatment for recurrent epithelial ovarian cancer (EOC). However, in some cases of oligometastatic recurrence, loco-regional treatment can be a useful therapeutic alternative. The ai…