Anna Maria Reuss
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View article: Neuropathological Characterisation of McLeod Syndrome With a Proposed New Grading System
Neuropathological Characterisation of McLeod Syndrome With a Proposed New Grading System Open
Aims X‐linked McLeod neuroacanthocytosis syndrome (MLS) is a rare neurodegenerative disorder characterised by the presence of red blood cell acanthocytosis and a chorea syndrome. Analogous to Huntington's disease (HD), MLS displays cogniti…
View article: aDISCO: A Broadly Applicable Method for 3D Microscopy of Archival Paraffin-Embedded Human Tissues
aDISCO: A Broadly Applicable Method for 3D Microscopy of Archival Paraffin-Embedded Human Tissues Open
During human surgeries and autopsies, specimens are regularly sampled and stored as formalin-fixed paraffin-embedded (FFPE) tissue blocks. Diagnoses are rendered by microscopical examination of two-dimensional sections. Good clinical pract…
View article: Quantitative 3D histochemistry reveals region-specific amyloid-β reduction by the antidiabetic drug netoglitazone
Quantitative 3D histochemistry reveals region-specific amyloid-β reduction by the antidiabetic drug netoglitazone Open
A hallmark of Alzheimer’s disease (AD) is the extracellular aggregation of toxic amyloid-beta (Aβ) peptides in form of plaques. Here, we identify netoglitazone, an antidiabetic compound previously tested in humans, as an Aβ aggregation ant…
View article: Quantitative 3D histochemistry reveals region-specific amyloid-β reduction by the antidiabetic drug netoglitazone
Quantitative 3D histochemistry reveals region-specific amyloid-β reduction by the antidiabetic drug netoglitazone Open
A hallmark of Alzheimer's disease (AD) is the extracellular aggregation of toxic amyloid-beta (Aβ) peptides in form of plaques. Here, we identify netoglitazone, an antidiabetic compound previously tested in humans, as an Aβ aggregation ant…
View article: Benchtop mesoSPIM: a next-generation open-source light-sheet microscope for cleared samples
Benchtop mesoSPIM: a next-generation open-source light-sheet microscope for cleared samples Open
View article: Leptomeningeal collaterals regulate reperfusion in ischemic stroke and rescue the brain from futile recanalization
Leptomeningeal collaterals regulate reperfusion in ischemic stroke and rescue the brain from futile recanalization Open
Recanalization is the mainstay of ischemic stroke treatment. However, even with timely clot removal, many stroke patients recover poorly. Leptomeningeal collaterals (LMCs) are pial anastomotic vessels with yet-unknown functions. We applied…
View article: The Benchtop mesoSPIM: a next-generation open-source light-sheet microscope for large cleared samples
The Benchtop mesoSPIM: a next-generation open-source light-sheet microscope for large cleared samples Open
In 2015, we launched the mesoSPIM initiative ( www.mesospim.org ), an open-source project for making light-sheet microscopy of large cleared tissues more accessible. Meanwhile, the demand for imaging larger samples at higher speed and reso…
View article: Reflective multi-immersion microscope objectives inspired by the Schmidt telescope
Reflective multi-immersion microscope objectives inspired by the Schmidt telescope Open
View article: Leptomeningeal collaterals regulate reperfusion in ischemic stroke
Leptomeningeal collaterals regulate reperfusion in ischemic stroke Open
Recanalization is the mainstay of ischemic stroke treatment. However, even with timely clot removal, many stroke patients recover poorly. Leptomeningeal collaterals (LMCs) are pial anastomotic vessels with yet unknown functions. Utilizing …
View article: A distinct hypothalamus-habenula circuit governs risk preference
A distinct hypothalamus-habenula circuit governs risk preference Open
Appropriate risk evaluation is essential for survival in complex, uncertain environments. Confronted with choosing between certain (safe) and uncertain (risky) options, animals show strong preference for either option consistently across e…
View article: Reflective multi-immersion microscope objectives inspired by the Schmidt telescope
Reflective multi-immersion microscope objectives inspired by the Schmidt telescope Open
Rapid advances in tissue clearing protocols have begun to outpace the capabilities of existing microscope objectives: High-resolution imaging inside cm-sized cleared samples is often not possible as it requires multi-immersion objectives w…
View article: Unsigned temporal difference errors in cortical L5 dendrites during learning
Unsigned temporal difference errors in cortical L5 dendrites during learning Open
Summary Learning goal-directed behavior requires association of pertinent sensory stimuli with behaviorally relevant outcomes. In the mammalian neocortex, dendrites of pyramidal neurons are suitable association sites 1–3 but how their acti…
View article: Blue-light treatment reduces spontaneous and evoked pain in a human experimental pain model
Blue-light treatment reduces spontaneous and evoked pain in a human experimental pain model Open
Introduction: Chronic pain is a frequent severe disease and often associated with anxiety, depression, insomnia, disability, and reduced quality of life. This maladaptive condition is further characterized by sensory loss, hyperalgesia, an…
View article: An unexpected intracerebral lesion – case report of a superinfected aspergillosis mimicking a brain metastasis
An unexpected intracerebral lesion – case report of a superinfected aspergillosis mimicking a brain metastasis Open
View article: An immunocompetent farmer with isolated cerebral alveolar echinococcosis: illustrative case
An immunocompetent farmer with isolated cerebral alveolar echinococcosis: illustrative case Open
BACKGROUND Alveolar echinococcosis is a rare condition, but living or working in a rural environment is a substantial risk factor. The liver is the organ primarily affected, with additional extrahepatic manifestations in approximately 25% …
View article: The Acidic Brain—Glycolytic Switch in the Microenvironment of Malignant Glioma
The Acidic Brain—Glycolytic Switch in the Microenvironment of Malignant Glioma Open
Malignant glioma represents a fatal disease with a poor prognosis and development of resistance mechanisms against conventional therapeutic approaches. The distinct tumor zones of this heterogeneous neoplasm develop their own microenvironm…
View article: MCT4 Promotes Tumor Malignancy in F98 Glioma Cells
MCT4 Promotes Tumor Malignancy in F98 Glioma Cells Open
Monocarboxylate transporter 4 (MCT4, SLC16A3) is elevated under hypoxic conditions in many malignant tumors including gliomas. Moreover, MCT4 expression is associated with shorter overall survival. However, the functional consequences of M…