Anna Markiewicz
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View article: Dualistic Role of MITF in Uveal Melanoma: Defining Two Distinct Cellular Subpopulations With Prognostic and Therapeutic Implications
Dualistic Role of MITF in Uveal Melanoma: Defining Two Distinct Cellular Subpopulations With Prognostic and Therapeutic Implications Open
MITF delineates two UM subpopulations: (1) MITF-low tumors-slow proliferators with high invasive potential and inflammatory phenotype, and (2) MITF-high tumors-rapidly dividing cells with lower invasiveness and immunosuppressive properties…
View article: Co-Targeting of DTYMK and PARP1 as a Potential Therapeutic Approach in Uveal Melanoma
Co-Targeting of DTYMK and PARP1 as a Potential Therapeutic Approach in Uveal Melanoma Open
Uveal melanoma (UM) is the most common primary intraocular tumor in adults, with no standardized treatment for advanced disease. Based on preliminary bioinformatical analyses DTYMK and PARP1 were selected as potential therapeutic targets. …
View article: Diagnostic Challenges in Inflammatory Choroidal Neovascularization
Diagnostic Challenges in Inflammatory Choroidal Neovascularization Open
Inflammation plays a key role in the induction of choroidal neovascularization (CNV). Inflammatory choroidal neovascularization (iCNV) is a severe but uncommon complication of both infectious and non-infectious uveitides. It is hypothesize…
View article: Diagnostic Challenges in Inflammatory Choroidal Neovascularization
Diagnostic Challenges in Inflammatory Choroidal Neovascularization Open
Inflammation plays a key role in the induction of choroidal neovascularization (CNV). Inflammatory choroidal neovascularization (iCNV) is a severe but uncommon complication of both infectious and non-infectious uveitides. It is hypothesize…
View article: Use of Optical Coherence Tomography and Optical Coherence Tomography Angiography in the Diagnosis and Follow-Up of Endogenous Candida Endophthalmitis: A Case Report
Use of Optical Coherence Tomography and Optical Coherence Tomography Angiography in the Diagnosis and Follow-Up of Endogenous Candida Endophthalmitis: A Case Report Open
Background: Endogenous Candida endophthalmitis (ECE) is a rare but sight-threatening disease. Patients with ECE present with various clinical signs and symptoms, which can complicate the diagnosis. The aim of this report was to demonstrate…
View article: Use of Optical Coherence Tomography and Optical Coherence Tomography Angiography in the Diagnosis and Follow-Up of Endogenous Candida Endophthalmitis: a Case Report.
Use of Optical Coherence Tomography and Optical Coherence Tomography Angiography in the Diagnosis and Follow-Up of Endogenous Candida Endophthalmitis: a Case Report. Open
Background: Endogenous Candida endophthalmitis (ECE) is a rare but sight-threatening disease. Patients with ECE present with various clinical signs and symptoms, which can complicate the diagnosis. The aim of this report was to describe th…
View article: Ki67 is a better marker than PRAME in risk stratification of BAP1-positive and BAP1-loss uveal melanomas
Ki67 is a better marker than PRAME in risk stratification of BAP1-positive and BAP1-loss uveal melanomas Open
Background Accurate risk stratification of uveal melanoma (UM) patients is important for determining the interval and frequency of surveillance. Loss of BAP1 expression has been shown to be strongly associated with UM-related death and met…
View article: Molecular profiling of primary uveal melanoma: results of a Polish cohort
Molecular profiling of primary uveal melanoma: results of a Polish cohort Open
There is no published data regarding the molecular alterations of Polish patients with primary uveal melanoma. We performed whole exome sequencing of 20 primary uveal melanomas (UMs), 10 metastasizing and 10 non-metastasizing cases to iden…
View article: Ophthalmic applicator displacement as a method of treating large diffuse uveal melanomas
Ophthalmic applicator displacement as a method of treating large diffuse uveal melanomas Open
Brachytherapy with ocular applicator displacement allows for the treatment of tumors with base measurements larger than 18 mm. The application of this method may be considered as an alternative for eye enucleation in particular cases of la…
View article: Diagnostic and therapeutic management of patients with ocular melanomas – recommendations of the Polish Society of Oncology
Diagnostic and therapeutic management of patients with ocular melanomas – recommendations of the Polish Society of Oncology Open
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View article: Amelanotic Uveal Melanomas Evaluated by Indirect Ophthalmoscopy Reveal Better Long-Term Prognosis Than Pigmented Primary Tumours—A Single Centre Experience
Amelanotic Uveal Melanomas Evaluated by Indirect Ophthalmoscopy Reveal Better Long-Term Prognosis Than Pigmented Primary Tumours—A Single Centre Experience Open
(1) Background: There is a constant search for new prognostic factors that would allow us to accurately determine the prognosis, select the type of treatment, and monitor the patient diagnosed with uveal melanoma in a minimally invasive an…
View article: The frequency of choroidal neovascularization from causes other than age-related macular degeneration in the Department of Ophthalmology and Ocular Oncology at the University Hospital in Kraków
The frequency of choroidal neovascularization from causes other than age-related macular degeneration in the Department of Ophthalmology and Ocular Oncology at the University Hospital in Kraków Open
Introduction: The aim of the study was to assess the frequency of choroidal neovascularization (CNV) from causes other than age-related macular degeneration (AMD). Diseases complicated by CNV were diagnosed using multimodal imaging of the …
View article: Analysis of Prognostic Factors Affecting Short-term and Long-term Outcomes of Gastric Cancer Resection
Analysis of Prognostic Factors Affecting Short-term and Long-term Outcomes of Gastric Cancer Resection Open
Early diagnosis and radical resection was crucial in 5-year survival rates. However, the type of gastrectomy and the resection of an additional organ were the most important factors in short-term outcomes of treatment for such patients.
View article: Diagnostic Algorithm for Conjunctival Melanocytic Lesions
Diagnostic Algorithm for Conjunctival Melanocytic Lesions Open
The use of the proposed algorithm, based on modified dermatoscopic characteristics, may be a valuable tool for the diagnosis of conjunctival melanoma.
View article: Choroidal metastases of thymic carcinoma in ultrasonographic imaging and optical coherence tomography
Choroidal metastases of thymic carcinoma in ultrasonographic imaging and optical coherence tomography Open
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View article: The Evaluation of the Malignant Characteristics of Conjunctival Lesions Based on the Dermatoscopic Algorithm
The Evaluation of the Malignant Characteristics of Conjunctival Lesions Based on the Dermatoscopic Algorithm Open
The patterns evaluated with dermatoscopy are present in pigmented lesions of the conjunctiva. There are, however, some characteristics which allow differentiation between melanoma and pigmented naevus and melanosis and also between PAM.
View article: Nuclear Pseudoinclusions and Intranuclear Grooves Have an Important Impact on the Long-term Survival of Patients With Uveal Melanoma
Nuclear Pseudoinclusions and Intranuclear Grooves Have an Important Impact on the Long-term Survival of Patients With Uveal Melanoma Open
The obtained results suggest that the presence of NGs in UM is associated with a better prognosis, as opposed to the presence of NPIs, which means the prognosis is worse.
View article: Brachytherapy or enucleation in ring melanoma patients: which is better? Preliminary results of the authors’ own experiences
Brachytherapy or enucleation in ring melanoma patients: which is better? Preliminary results of the authors’ own experiences Open
Preliminary observations may suggest that brachytherapy in this rare form of uveal melanoma, such as ring melanoma involving the ciliary body, may be taken into consideration as a useful alternative to enucleation. However, the confirmatio…
View article: Downregulation of Polo-like kinase-1 (PLK-1) expression is associated with poor clinical outcome in uveal melanoma patients
Downregulation of Polo-like kinase-1 (PLK-1) expression is associated with poor clinical outcome in uveal melanoma patients Open
Downregulated PLK-1 expression is a negative prognostic factor in uveal melanoma. It warrants further, multicentre research on prognostic role of PLK-1 expression and possibility of PLK-1 inhibition in uveal melanoma.
View article: Clinical Significance of Nucleoli Cytomorphology Assessment in Patients With Uveal Melanoma
Clinical Significance of Nucleoli Cytomorphology Assessment in Patients With Uveal Melanoma Open
Histological assessment of nucleolar morphology in routine HE staining would be a helpful low-cost method to obtain reliable prognostic information.
View article: Prevention and treatment of the toxic tumour syndrome following primary proton beam therapy of choroidal melanomas
Prevention and treatment of the toxic tumour syndrome following primary proton beam therapy of choroidal melanomas Open
Introduction The aim of this study was to evaluate the efficacy and safety of endoresection for choroidal melanoma to prevent and treat the toxic tumour syndrome (TTS). Material and methods Thirteen patients who underwent primary proton be…
View article: Mars Polonicus. Wokół paryskich dysput braci Jabłonowskich z 1686 roku
Mars Polonicus. Wokół paryskich dysput braci Jabłonowskich z 1686 roku Open
Public and religious ceremonies were part of the daily life of many Jesuit colleges throughout Europe. The Jesuit education was enriched by numerous occasional celebrations and events, of which many were closely related to the academic yea…
View article: Clinical and histopathological evaluation of 312 excised conjunctival tumors
Clinical and histopathological evaluation of 312 excised conjunctival tumors Open
ENWEndNote BIBJabRef, Mendeley RISPapers, Reference Manager, RefWorks, Zotero AMA Dębicka-Kumela M, Karska-Basta I, Markiewicz A, Bogdali A, Kowal J, Romanowska-Dixon B. Clinical and histopathological evaluation of 312 excised conjunctival…
View article: Analysis of local recurrence causes in uveal melanoma patients treated with 125I brachytherapy – a single institution study
Analysis of local recurrence causes in uveal melanoma patients treated with 125I brachytherapy – a single institution study Open
Treatment of uveal melanomas with 125I applicators allows for a high rate of positive local results. Nonetheless, the recurrence probability always exists. The involvement of the ciliary body could influence this. The survival depending on…
View article: Transplantable Melanomas in Hamsters and Gerbils as Models for Human Melanoma. Sensitization in Melanoma Radiotherapy—From Animal Models to Clinical Trials
Transplantable Melanomas in Hamsters and Gerbils as Models for Human Melanoma. Sensitization in Melanoma Radiotherapy—From Animal Models to Clinical Trials Open
The focus of the present review is to investigate the role of melanin in the radioprotection of melanoma and attempts to sensitize tumors to radiation by inhibiting melanogenesis. Early studies showed radical scavenging, oxygen consumption…
View article: Outcomes of I-125 brachytherapy for uveal melanomas depending on irradiation dose applied to the tumor apex – a single institution study
Outcomes of I-125 brachytherapy for uveal melanomas depending on irradiation dose applied to the tumor apex – a single institution study Open
The treatment of choroidal melanomas with I-125 iodine isotope brachytherapy is an efficient and recommended method of treatment and in many cases, an alternative to the enucleation of an eyeball.