Anna Mizutani
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View article: APC/PIK3CA mutations and β-catenin status predict tankyrase inhibitor sensitivity of patient-derived colorectal cancer cells
APC/PIK3CA mutations and β-catenin status predict tankyrase inhibitor sensitivity of patient-derived colorectal cancer cells Open
View article: Supplementary Table S1 from <i>APC</i> Mutations as a Potential Biomarker for Sensitivity to Tankyrase Inhibitors in Colorectal Cancer
Supplementary Table S1 from <i>APC</i> Mutations as a Potential Biomarker for Sensitivity to Tankyrase Inhibitors in Colorectal Cancer Open
IC50 values of colorectal cancer cell lines and colorectal cancer patient-derived cells
View article: Supplementary Table S2 from <i>APC</i> Mutations as a Potential Biomarker for Sensitivity to Tankyrase Inhibitors in Colorectal Cancer
Supplementary Table S2 from <i>APC</i> Mutations as a Potential Biomarker for Sensitivity to Tankyrase Inhibitors in Colorectal Cancer Open
Multiple regression analysis of tankyrase inhibitor sensitivities and genetic mutations in colorectal cancer cell lines
View article: Data from <i>APC</i> Mutations as a Potential Biomarker for Sensitivity to Tankyrase Inhibitors in Colorectal Cancer
Data from <i>APC</i> Mutations as a Potential Biomarker for Sensitivity to Tankyrase Inhibitors in Colorectal Cancer Open
In most colorectal cancers, Wnt/β-catenin signaling is activated by loss-of-function mutations in the adenomatous polyposis coli (APC) gene and plays a critical role in tumorigenesis. Tankyrases poly(ADP-ribosyl)ate and desta…
View article: Supplementary Figure Legends from <i>APC</i> Mutations as a Potential Biomarker for Sensitivity to Tankyrase Inhibitors in Colorectal Cancer
Supplementary Figure Legends from <i>APC</i> Mutations as a Potential Biomarker for Sensitivity to Tankyrase Inhibitors in Colorectal Cancer Open
Legends for Supplementary Figure S1-S8
View article: Supplementary Table S2 from <i>APC</i> Mutations as a Potential Biomarker for Sensitivity to Tankyrase Inhibitors in Colorectal Cancer
Supplementary Table S2 from <i>APC</i> Mutations as a Potential Biomarker for Sensitivity to Tankyrase Inhibitors in Colorectal Cancer Open
Multiple regression analysis of tankyrase inhibitor sensitivities and genetic mutations in colorectal cancer cell lines
View article: Supplementary Figure S1-S8 from <i>APC</i> Mutations as a Potential Biomarker for Sensitivity to Tankyrase Inhibitors in Colorectal Cancer
Supplementary Figure S1-S8 from <i>APC</i> Mutations as a Potential Biomarker for Sensitivity to Tankyrase Inhibitors in Colorectal Cancer Open
Supplementary Figure S1: Full scans of the immunoblots shown in Figs. 1C, 2A and 4A. Supplementary Figure S2: Basal expression of tankyrase, Axins, and β-catenin and intracellular localization of β-catenin in CRC cell lines used in this st…
View article: Supplementary Figure Legends from <i>APC</i> Mutations as a Potential Biomarker for Sensitivity to Tankyrase Inhibitors in Colorectal Cancer
Supplementary Figure Legends from <i>APC</i> Mutations as a Potential Biomarker for Sensitivity to Tankyrase Inhibitors in Colorectal Cancer Open
Legends for Supplementary Figure S1-S8
View article: Data from <i>APC</i> Mutations as a Potential Biomarker for Sensitivity to Tankyrase Inhibitors in Colorectal Cancer
Data from <i>APC</i> Mutations as a Potential Biomarker for Sensitivity to Tankyrase Inhibitors in Colorectal Cancer Open
In most colorectal cancers, Wnt/β-catenin signaling is activated by loss-of-function mutations in the adenomatous polyposis coli (APC) gene and plays a critical role in tumorigenesis. Tankyrases poly(ADP-ribosyl)ate and desta…
View article: Supplementary Table S1 from <i>APC</i> Mutations as a Potential Biomarker for Sensitivity to Tankyrase Inhibitors in Colorectal Cancer
Supplementary Table S1 from <i>APC</i> Mutations as a Potential Biomarker for Sensitivity to Tankyrase Inhibitors in Colorectal Cancer Open
IC50 values of colorectal cancer cell lines and colorectal cancer patient-derived cells
View article: Supplementary Figure S1-S8 from <i>APC</i> Mutations as a Potential Biomarker for Sensitivity to Tankyrase Inhibitors in Colorectal Cancer
Supplementary Figure S1-S8 from <i>APC</i> Mutations as a Potential Biomarker for Sensitivity to Tankyrase Inhibitors in Colorectal Cancer Open
Supplementary Figure S1: Full scans of the immunoblots shown in Figs. 1C, 2A and 4A. Supplementary Figure S2: Basal expression of tankyrase, Axins, and β-catenin and intracellular localization of β-catenin in CRC cell lines used in this st…
View article: Design and Discovery of an Orally Efficacious Spiroindolinone-Based Tankyrase Inhibitor for the Treatment of Colon Cancer
Design and Discovery of an Orally Efficacious Spiroindolinone-Based Tankyrase Inhibitor for the Treatment of Colon Cancer Open
Tankyrases (TNKS/TNKS2) belong to the poly(ADP-ribose) polymerase family. Inhibition of their enzymatic activities attenuates the Wnt/β-catenin signaling, which plays an important role in cancer pathogenesis. We previously reported the dis…
View article: Design and Discoveryof an Orally Efficacious Spiroindolinone-BasedTankyrase Inhibitor for the Treatment of Colon Cancer
Design and Discoveryof an Orally Efficacious Spiroindolinone-BasedTankyrase Inhibitor for the Treatment of Colon Cancer Open
Tankyrases\n(TNKS/TNKS2) belong to the poly(ADP-ribose) polymerase\nfamily. Inhibition of their enzymatic activities attenuates the Wnt/β-catenin\nsignaling, which plays an important role in cancer pathogenesis. We\npreviously reported th…
View article: Discovery of Novel Spiroindoline Derivatives as Selective Tankyrase Inhibitors
Discovery of Novel Spiroindoline Derivatives as Selective Tankyrase Inhibitors Open
The canonical WNT pathway plays an important role in cancer pathogenesis. Inhibition of poly(ADP-ribose) polymerase catalytic activity of the tankyrases (TNKS/TNKS2) has been reported to reduce the Wnt/β-catenin signal by preventing poly A…
View article: <scp>RK</scp>‐287107, a potent and specific tankyrase inhibitor, blocks colorectal cancer cell growth in a preclinical model
<span>RK</span>‐287107, a potent and specific tankyrase inhibitor, blocks colorectal cancer cell growth in a preclinical model Open
Aberrant activation of Wnt/β‐catenin signaling causes tumorigenesis and promotes the proliferation of colorectal cancer cells. Porcupine inhibitors, which block secretion of Wnt ligands, may have only limited clinical impact for the treatm…
View article: <scp>ZEB</scp>1‐regulated inflammatory phenotype in breast cancer cells
<span>ZEB</span>1‐regulated inflammatory phenotype in breast cancer cells Open
Zinc finger E‐box binding protein 1 ( ZEB 1) and ZEB 2 induce epithelial‐mesenchymal transition ( EMT ) and enhance cancer progression. However, the global view of transcriptional regulation by ZEB 1 and ZEB 2 is yet to be elucidated. Here…
View article: mTOR signaling mediates resistance to tankyrase inhibitors in Wnt-driven colorectal cancer
mTOR signaling mediates resistance to tankyrase inhibitors in Wnt-driven colorectal cancer Open
Activation of Wnt/β-catenin signaling is essential for colorectal carcinogenesis. Tankyrase, a member of the poly(ADP-ribose) polymerase (PARP) family, is a positive regulator of the Wnt/β-catenin signaling. Accordingly, tankyrase inhibito…
View article: Dynamics of chromatin accessibility during TGF-β-induced EMT of Ras-transformed mammary gland epithelial cells
Dynamics of chromatin accessibility during TGF-β-induced EMT of Ras-transformed mammary gland epithelial cells Open
Epithelial-mesenchymal transition (EMT) is induced by transforming growth factor (TGF)-β and facilitates tumor progression. We here performed global mapping of accessible chromatin in the mouse mammary gland epithelial EpH4 cell line and i…
View article: BMP Sustains Embryonic Stem Cell Self-Renewal through Distinct Functions of Different Krüppel-like Factors
BMP Sustains Embryonic Stem Cell Self-Renewal through Distinct Functions of Different Krüppel-like Factors Open
View article: The Arkadia-ESRP2 axis suppresses tumor progression: analyses in clear-cell renal cell carcinoma
The Arkadia-ESRP2 axis suppresses tumor progression: analyses in clear-cell renal cell carcinoma Open
Tumor-specific alternative splicing is implicated in the progression of cancer, including clear-cell renal cell carcinoma (ccRCC). Using ccRCC RNA sequencing data from The Cancer Genome Atlas, we found that epithelial splicing regulatory p…