Anna Mularski
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View article: Viscoelastic differences between isolated and live MCF7 cancer cell nuclei resolved with AFM microrheology
Viscoelastic differences between isolated and live MCF7 cancer cell nuclei resolved with AFM microrheology Open
Cell nuclei are commonly isolated for mechanobiology studies although isolated nuclei may display viscoelastic properties differing from those of live cells. Nuclear mechanics is generally dependent on the time scale of the applied load an…
View article: On the synergy between myelin proteins <scp>P</scp> 0, <scp>MBP</scp> , and <scp>P</scp> 2 in peripheral nerve major dense line formation
On the synergy between myelin proteins <span>P</span> 0, <span>MBP</span> , and <span>P</span> 2 in peripheral nerve major dense line formation Open
The proper formation and function of the myelin sheath, a proteolipid membrane multilayer, relies on the coordinated action of several key myelin proteins. We studied how proteins from the peripheral myelin cytoplasmic apposition—myelin ba…
View article: A crosstalk between adhesion and phagocytosis integrates macrophage functions into their microenvironment
A crosstalk between adhesion and phagocytosis integrates macrophage functions into their microenvironment Open
View article: On the synergy between myelin proteins P0, MBP, and P2 in peripheral nerve major dense line formation
On the synergy between myelin proteins P0, MBP, and P2 in peripheral nerve major dense line formation Open
Myelin is a proteolipid membrane multilayer held together by a set of proteins. The proper formation and function of the myelin sheath relies on the coordinated action of several key myelin proteins. Research exploring how proteins from th…
View article: The cytoplasmic tail of myelin protein zero induces morphological changes in lipid membranes
The cytoplasmic tail of myelin protein zero induces morphological changes in lipid membranes Open
The major myelin protein expressed by the peripheral nervous system Schwann cells is protein zero (P0), which represents 50% of the total protein content in myelin. This 30-kDa integral membrane protein consists of an immunoglobulin (Ig)-l…
View article: The cytoplasmic tail of myelin protein zero induces morphological changes in lipid membranes
The cytoplasmic tail of myelin protein zero induces morphological changes in lipid membranes Open
The major myelin protein expressed by the peripheral nervous system Schwann cells is protein zero (P0), representing 50% of the total protein content in myelin. This 30-kDa integral membrane protein consists of an immunoglobulin (Ig)-like …
View article: Dynamin‐2 controls actin remodeling for efficient complement receptor 3‐mediated phagocytosis
Dynamin‐2 controls actin remodeling for efficient complement receptor 3‐mediated phagocytosis Open
Background information Phagocytosis is the mechanism of the internalization of large particles, microorganisms and cellular debris. The complement pathway represents one of the first mechanisms of defense against infection and the compleme…
View article: Engineering a membrane-binding protein to trimerize and induce high membrane curvature
Engineering a membrane-binding protein to trimerize and induce high membrane curvature Open
View article: Interplay of membrane crosslinking and curvature induction by annexins
Interplay of membrane crosslinking and curvature induction by annexins Open
Efficient plasma membrane repair (PMR) is required to repair damage sustained in the cellular life cycle. The annexin family of proteins, involved in PMR, are activated by Ca 2+ influx from extracellular media at the site of injury. Mechan…
View article: LPS O Antigen Plays a Key Role in Klebsiella pneumoniae Capsule Retention
LPS O Antigen Plays a Key Role in Klebsiella pneumoniae Capsule Retention Open
Bacterial capsules, typically comprised of complex sugars, enable pathogens to avoid key host responses to infection, including phagocytosis. These capsules are synthesized within the bacteria, exported through the outer envelope, and then…
View article: Phenothiazines alter plasma membrane properties and sensitize cancer cells to injury by inhibiting annexin-mediated repair
Phenothiazines alter plasma membrane properties and sensitize cancer cells to injury by inhibiting annexin-mediated repair Open
View article: Dynamin-2 controls complement receptor 3- mediated phagocytosis completion and closure
Dynamin-2 controls complement receptor 3- mediated phagocytosis completion and closure Open
Phagocytosis is the mechanism of the internalization of large particles, microorganisms and cellular debris. The complement pathway represents one of the first mechanisms of defense against infection and the complement receptor 3 (CR3), wh…
View article: Interdisciplinary Synergy to Reveal Mechanisms of Annexin-Mediated Plasma Membrane Shaping and Repair
Interdisciplinary Synergy to Reveal Mechanisms of Annexin-Mediated Plasma Membrane Shaping and Repair Open
The plasma membrane surrounds every single cell and essentially shapes cell life by separating the interior from the external environment. Thus, maintenance of cell membrane integrity is essential to prevent death caused by disruption of t…
View article: Force Measurement of Living Professional Phagocytes of the Immune System
Force Measurement of Living Professional Phagocytes of the Immune System Open
In higher organisms, the professional phagocytes of the immune system (dendritic cells, neutrophils, monocytes, and macrophages) are responsible for pathogen clearance, the development of immune responses via cytokine secretion and present…
View article: Arpin is critical for phagocytosis in macrophages and is targeted by human rhinovirus
Arpin is critical for phagocytosis in macrophages and is targeted by human rhinovirus Open
View article: A nanomechanical study of the effects of colistin on the Klebsiella pneumoniae AJ218 capsule
A nanomechanical study of the effects of colistin on the Klebsiella pneumoniae AJ218 capsule Open
View article: Atomic force microscopy of bacteria reveals the mechanobiology of pore forming peptide action
Atomic force microscopy of bacteria reveals the mechanobiology of pore forming peptide action Open