Anna Munke
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View article: Structural diversity and conservation among CRESS-DNA bacilladnaviruses revealed through cryo-EM and computational modelling
Structural diversity and conservation among CRESS-DNA bacilladnaviruses revealed through cryo-EM and computational modelling Open
Viruses that infect single-celled algae strongly regulate microalgae growth and community composition through cell lysis, enable nutrient recycling in marine ecosystems, and offer valuable insights into early stages of viral evolution. One…
View article: Structure of the T=13 capsid of infectious pancreatic necrosis virus (IPNV)—a salmonid birnavirus
Structure of the T=13 capsid of infectious pancreatic necrosis virus (IPNV)—a salmonid birnavirus Open
Birnaviruses infect a broad range of vertebrate hosts, including fish and birds, and cause substantial economic losses in the fishery and livestock industries. The infectious pancreatic necrosis virus (IPNV), an aquabirnavirus, specificall…
View article: Real-time data processing for serial crystallography experiments
Real-time data processing for serial crystallography experiments Open
We report the use of streaming data interfaces to perform fully online data processing for serial crystallography experiments, without storing intermediate data on disk. The system produces Bragg reflection intensity measurements suitable …
View article: Structure of the T=13 capsid of infectious pancreatic necrosis virus (IPNV) - a salmonid birnavirus
Structure of the T=13 capsid of infectious pancreatic necrosis virus (IPNV) - a salmonid birnavirus Open
Birnaviruses infect a broad range of vertebrate hosts, including fishes and birds, and cause substantial economic losses in the fishery and livestock industries. The infectious pancreatic necrosis virus (IPNV), an aquabirnavirus, specifica…
View article: Observation of Aerosolization-induced Morphological Changes in Viral Capsids
Observation of Aerosolization-induced Morphological Changes in Viral Capsids Open
Single-stranded RNA viruses co-assemble their capsid with the genome and variations in capsid structures can have significant functional relevance. In particular, viruses need to respond to a dehydrating environment to prevent genomic degr…
View article: High-resolution comparative atomic structures of two Giardiavirus prototypes infecting G. duodenalis parasite
High-resolution comparative atomic structures of two Giardiavirus prototypes infecting G. duodenalis parasite Open
The Giardia lamblia virus (GLV) is a non-enveloped icosahedral dsRNA and endosymbiont virus that infects the zoonotic protozoan parasite Giardia duodenalis (syn. G . lamblia , G . intestinalis ), which is a pathogen of mammals, including h…
View article: Structure of the <i>Lysinibacillus sphaericus</i> Tpp49Aa1 pesticidal protein elucidated from natural crystals using MHz-SFX
Structure of the <i>Lysinibacillus sphaericus</i> Tpp49Aa1 pesticidal protein elucidated from natural crystals using MHz-SFX Open
The Lysinibacillus sphaericus proteins Tpp49Aa1 and Cry48Aa1 can together act as a toxin toward the mosquito Culex quinquefasciatus and have potential use in biocontrol. Given that proteins with sequence homology to the individual proteins…
View article: High-resolution comparative atomic structures of two Giardiavirus prototypes infecting<i>G. duodenalis</i>parasite
High-resolution comparative atomic structures of two Giardiavirus prototypes infecting<i>G. duodenalis</i>parasite Open
Giardia lamblia virus (GLV) is a non-enveloped icosahedral dsRNA virus and an endosymbiont virus infecting the zoonotic protozoan parasite Giardia duodenalis (syn. G. lamblia, G. intestinalis ), a pathogen of mammals, including humans. Elu…
View article: Structural Insights into Common and Host-Specific Receptor-Binding Mechanisms in Algal Picorna-like Viruses
Structural Insights into Common and Host-Specific Receptor-Binding Mechanisms in Algal Picorna-like Viruses Open
Marnaviridae viruses are abundant algal viruses that regulate the dynamics of algal blooms in aquatic environments. They employ a narrow host range because they merely lyse their algal host species. This host-specific lysis is thought to c…
View article: Structural Insights into Common and Host-Specific Transmission Mechanisms in Algal Picorna-Like Viruses
Structural Insights into Common and Host-Specific Transmission Mechanisms in Algal Picorna-Like Viruses Open
Marnaviridae viruses are abundant algal viruses that regulate the dynamics of algal blooms in aquatic environments. They employ a narrow host range because they merely lyse their own algal host species. This host-specific lysis is thought …
View article: Primordial Capsid and Spooled ssDNA Genome Structures Unravel Ancestral Events of Eukaryotic Viruses
Primordial Capsid and Spooled ssDNA Genome Structures Unravel Ancestral Events of Eukaryotic Viruses Open
Single-stranded DNA (ssDNA) viruses are an extremely widespread group of viruses that infect diverse hosts from all three domains of life, consequently having great economic, medical, and ecological importance. In particular, bacilladnavir…
View article: Structure of the<i>Lysinibacillus sphaericus</i>Tpp49Aa1 pesticidal protein elucidated from natural crystals using MHz-SFX
Structure of the<i>Lysinibacillus sphaericus</i>Tpp49Aa1 pesticidal protein elucidated from natural crystals using MHz-SFX Open
Tpp49Aa1 from Lysinibacillus sphaericus is a Toxin_10 family protein that – in combination with Cry48Aa1, a 3-domain crystal protein - has potent mosquitocidal activity, specifically against Culex quinquefasciatus mosquitoes. MHz serial fe…
View article: Primordial capsid and spooled ssDNA genome structures penetrate ancestral events of eukaryotic viruses
Primordial capsid and spooled ssDNA genome structures penetrate ancestral events of eukaryotic viruses Open
Marine algae viruses are important for controlling microorganism communities in the marine ecosystem and played fundamental roles during the early events of viral evolution. Here, we have focused on one major group of marine algae viruses,…
View article: Capsid Structure of a Marine Algal Virus of the Order <i>Picornavirales</i>
Capsid Structure of a Marine Algal Virus of the Order <i>Picornavirales</i> Open
Identifying the acquired structural traits in virus capsids is important for elucidating what functions are essential among viruses that infect different hosts. The Picornavirales viruses infect a broad spectrum of hosts, ranging from unic…
View article: Electrospray sample injection for single-particle imaging with x-ray lasers
Electrospray sample injection for single-particle imaging with x-ray lasers Open
Electrospray contaminant-free delivery of proteins to x-ray laser heralds the start of single-protein x-ray diffractive imaging.
View article: Electrospray sample injection for single-particle imaging with X-ray lasers
Electrospray sample injection for single-particle imaging with X-ray lasers Open
The possibility of imaging single proteins constitutes an exciting challenge for X-ray lasers. Despite encouraging results on large particles, imaging small particles has proven to be difficult for two reasons: not quite high enough pulse …
View article: Correlations in Scattered X-Ray Laser Pulses Reveal Nanoscale Structural Features of Viruses
Correlations in Scattered X-Ray Laser Pulses Reveal Nanoscale Structural Features of Viruses Open
We use extremely bright and ultrashort pulses from an x-ray free-electron laser (XFEL) to measure correlations in x rays scattered from individual bioparticles. This allows us to go beyond the traditional crystallography and single-particl…
View article: Coherent soft X-ray diffraction imaging of coliphage PR772 at the Linac coherent light source
Coherent soft X-ray diffraction imaging of coliphage PR772 at the Linac coherent light source Open
Single-particle diffraction from X-ray Free Electron Lasers offers the potential for molecular structure determination without the need for crystallization. In an effort to further develop the technique, we present a dataset of coherent so…
View article: Phage display and kinetic selection of antibodies that specifically inhibit amyloid self-replication
Phage display and kinetic selection of antibodies that specifically inhibit amyloid self-replication Open
Significance The promise of antibody-based strategies to combat Alzheimer’s disease by inhibiting the aggregation of the amyloid β peptide (Aβ) has not yet been realized in clinical trials. In part, this situation has arisen because the an…
View article: Coherent diffraction of single Rice Dwarf Virus particles using hard X-rays at the Linac Coherent Light Source (CXIDB ID 36)
Coherent diffraction of single Rice Dwarf Virus particles using hard X-rays at the Linac Coherent Light Source (CXIDB ID 36) Open
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View article: Size measurements of Rice Dwarf Virus (RDV) in the liquid and gas phase
Size measurements of Rice Dwarf Virus (RDV) in the liquid and gas phase Open
Size measurements of Rice Dwarf Virus (RDV) in the liquid and gas phase.
View article: Data Citation 1 - DLS,NTA,DMA.xlsx
Data Citation 1 - DLS,NTA,DMA.xlsx Open
Size measurements of Rice Dwarf Virus (RDV) in the liquid and gas phase.