Anna S. Nikonova
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View article: Loss of Pkd1 limits susceptibility to colitis and colorectal cancer
Loss of Pkd1 limits susceptibility to colitis and colorectal cancer Open
Colorectal cancer (CRC) is one of the most common cancers, with an annual incidence of ~135,000 in the US, associated with ~50,000 deaths. Autosomal dominant polycystic kidney disease (ADPKD), associated with mutations disabling the PKD1 g…
View article: Supplementary Table 1 from Targeting C4-Demethylating Genes in the Cholesterol Pathway Sensitizes Cancer Cells to EGF Receptor Inhibitors via Increased EGF Receptor Degradation
Supplementary Table 1 from Targeting C4-Demethylating Genes in the Cholesterol Pathway Sensitizes Cancer Cells to EGF Receptor Inhibitors via Increased EGF Receptor Degradation Open
PDF file - 23K, Summary of Interactions for sterol pathway genes
View article: Supplementary Figures 1-10 from Targeting C4-Demethylating Genes in the Cholesterol Pathway Sensitizes Cancer Cells to EGF Receptor Inhibitors via Increased EGF Receptor Degradation
Supplementary Figures 1-10 from Targeting C4-Demethylating Genes in the Cholesterol Pathway Sensitizes Cancer Cells to EGF Receptor Inhibitors via Increased EGF Receptor Degradation Open
PDF file - 1.2MB, Fig. S1. Validation of the sterol pathway targeting siRNA. Fig. S2. Silencing of SC4MOL increased erlotinib-induced apoptosis. Fig. S3. Metabolic effects of SC4MOL silencing and sterols supplementation. Fig. S4. Sterol pa…
View article: Data from Targeting C4-Demethylating Genes in the Cholesterol Pathway Sensitizes Cancer Cells to EGF Receptor Inhibitors via Increased EGF Receptor Degradation
Data from Targeting C4-Demethylating Genes in the Cholesterol Pathway Sensitizes Cancer Cells to EGF Receptor Inhibitors via Increased EGF Receptor Degradation Open
Persistent signaling by the oncogenic EGF receptor (EGFR) is a major source of cancer resistance to EGFR targeting. We established that inactivation of 2 sterol biosynthesis pathway genes, SC4MOL (sterol C4-methyl oxidase–like) and its par…
View article: Data from Targeting C4-Demethylating Genes in the Cholesterol Pathway Sensitizes Cancer Cells to EGF Receptor Inhibitors via Increased EGF Receptor Degradation
Data from Targeting C4-Demethylating Genes in the Cholesterol Pathway Sensitizes Cancer Cells to EGF Receptor Inhibitors via Increased EGF Receptor Degradation Open
Persistent signaling by the oncogenic EGF receptor (EGFR) is a major source of cancer resistance to EGFR targeting. We established that inactivation of 2 sterol biosynthesis pathway genes, SC4MOL (sterol C4-methyl oxidase–like) and its par…
View article: Supplementary Figure Legends 1-10, Table 2 from Targeting C4-Demethylating Genes in the Cholesterol Pathway Sensitizes Cancer Cells to EGF Receptor Inhibitors via Increased EGF Receptor Degradation
Supplementary Figure Legends 1-10, Table 2 from Targeting C4-Demethylating Genes in the Cholesterol Pathway Sensitizes Cancer Cells to EGF Receptor Inhibitors via Increased EGF Receptor Degradation Open
PDF file - 105K
View article: Supplementary Figure Legends 1-10, Table 2 from Targeting C4-Demethylating Genes in the Cholesterol Pathway Sensitizes Cancer Cells to EGF Receptor Inhibitors via Increased EGF Receptor Degradation
Supplementary Figure Legends 1-10, Table 2 from Targeting C4-Demethylating Genes in the Cholesterol Pathway Sensitizes Cancer Cells to EGF Receptor Inhibitors via Increased EGF Receptor Degradation Open
PDF file - 105K
View article: Supplementary Figures 1-10 from Targeting C4-Demethylating Genes in the Cholesterol Pathway Sensitizes Cancer Cells to EGF Receptor Inhibitors via Increased EGF Receptor Degradation
Supplementary Figures 1-10 from Targeting C4-Demethylating Genes in the Cholesterol Pathway Sensitizes Cancer Cells to EGF Receptor Inhibitors via Increased EGF Receptor Degradation Open
PDF file - 1.2MB, Fig. S1. Validation of the sterol pathway targeting siRNA. Fig. S2. Silencing of SC4MOL increased erlotinib-induced apoptosis. Fig. S3. Metabolic effects of SC4MOL silencing and sterols supplementation. Fig. S4. Sterol pa…
View article: Supplementary Table 1 from Targeting C4-Demethylating Genes in the Cholesterol Pathway Sensitizes Cancer Cells to EGF Receptor Inhibitors via Increased EGF Receptor Degradation
Supplementary Table 1 from Targeting C4-Demethylating Genes in the Cholesterol Pathway Sensitizes Cancer Cells to EGF Receptor Inhibitors via Increased EGF Receptor Degradation Open
PDF file - 23K, Summary of Interactions for sterol pathway genes
View article: Supplementary Figure S1 from <i>Nedd9</i> Restrains Autophagy to Limit Growth of Early Stage Non–Small Cell Lung Cancer
Supplementary Figure S1 from <i>Nedd9</i> Restrains Autophagy to Limit Growth of Early Stage Non–Small Cell Lung Cancer Open
Images of airspace volume
View article: Data from <i>Nedd9</i> Restrains Autophagy to Limit Growth of Early Stage Non–Small Cell Lung Cancer
Data from <i>Nedd9</i> Restrains Autophagy to Limit Growth of Early Stage Non–Small Cell Lung Cancer Open
Non–small cell lung cancer (NSCLC) is the most common cancer worldwide. With overall 5-year survival estimated at <17%, it is critical to identify factors that regulate NSCLC disease prognosis. NSCLC is commonly driven by mutations in KRAS…
View article: Data from A Novel HSP90 Inhibitor–Drug Conjugate to SN38 Is Highly Effective in Small Cell Lung Cancer
Data from A Novel HSP90 Inhibitor–Drug Conjugate to SN38 Is Highly Effective in Small Cell Lung Cancer Open
Purpose: Small cell lung cancer (SCLC) is a highly aggressive disease representing 12% to 13% of total lung cancers, with median survival of Experimental Design: To avoid DLT for useful cytotoxic agents, the recently developed drug STA-866…
View article: Supplementary Figure Legend from Quantification of Excision Repair Cross-Complementing Group 1 and Survival in p16-Negative Squamous Cell Head and Neck Cancers
Supplementary Figure Legend from Quantification of Excision Repair Cross-Complementing Group 1 and Survival in p16-Negative Squamous Cell Head and Neck Cancers Open
PDF file - 56K
View article: Supplementary Video S1 from Unexpected Activities in Regulating Ciliation Contribute to Off-target Effects of Targeted Drugs
Supplementary Video S1 from Unexpected Activities in Regulating Ciliation Contribute to Off-target Effects of Targeted Drugs Open
Supplementary Video S1. Time-lapse images of hTERT-RPE1-Arl13b-GFP cells starved in serum-free Opti-MEM for 48 hours.
View article: Supplementary Materials and Methods from A Novel HSP90 Inhibitor–Drug Conjugate to SN38 Is Highly Effective in Small Cell Lung Cancer
Supplementary Materials and Methods from A Novel HSP90 Inhibitor–Drug Conjugate to SN38 Is Highly Effective in Small Cell Lung Cancer Open
Supplemental Materials and Methods and supplemental figure legends
View article: Table S1 from A Novel HSP90 Inhibitor–Drug Conjugate to SN38 Is Highly Effective in Small Cell Lung Cancer
Table S1 from A Novel HSP90 Inhibitor–Drug Conjugate to SN38 Is Highly Effective in Small Cell Lung Cancer Open
Supplemental Table 1
View article: Supplementary Video S4 from Unexpected Activities in Regulating Ciliation Contribute to Off-target Effects of Targeted Drugs
Supplementary Video S4 from Unexpected Activities in Regulating Ciliation Contribute to Off-target Effects of Targeted Drugs Open
Supplementary Video S4. Time-lapse images of hTERT-RPE1-Arl13b-GFP cells starved in serum-free Opti-MEM for 48 hours, then incubated for 3 hours in 1 µM ganetespib.
View article: Supplementary Figure S5 from <i>Nedd9</i> Restrains Autophagy to Limit Growth of Early Stage Non–Small Cell Lung Cancer
Supplementary Figure S5 from <i>Nedd9</i> Restrains Autophagy to Limit Growth of Early Stage Non–Small Cell Lung Cancer Open
NEDD9 mutations and survival based on tumor size and NEDD9 expression in TCGA data
View article: Supplementary figures 1-8 from Unexpected Activities in Regulating Ciliation Contribute to Off-target Effects of Targeted Drugs
Supplementary figures 1-8 from Unexpected Activities in Regulating Ciliation Contribute to Off-target Effects of Targeted Drugs Open
Supplementary Figure S1. Additional analysis of siRNA effects on ciliation and target depleton. Supplementary Figure S2. Sorafenib is similar to sunitinib in inducing ciliary resorption. Supplementary Figure S3. Effect of compounds on AURK…
View article: Supplementary Table S3 from Unexpected Activities in Regulating Ciliation Contribute to Off-target Effects of Targeted Drugs
Supplementary Table S3 from Unexpected Activities in Regulating Ciliation Contribute to Off-target Effects of Targeted Drugs Open
Supplementary Table S3. List of primers used for qRT-PCR.
View article: Supplementary figures 1-8 from Unexpected Activities in Regulating Ciliation Contribute to Off-target Effects of Targeted Drugs
Supplementary figures 1-8 from Unexpected Activities in Regulating Ciliation Contribute to Off-target Effects of Targeted Drugs Open
Supplementary Figure S1. Additional analysis of siRNA effects on ciliation and target depleton. Supplementary Figure S2. Sorafenib is similar to sunitinib in inducing ciliary resorption. Supplementary Figure S3. Effect of compounds on AURK…
View article: Table S1 from A Novel HSP90 Inhibitor–Drug Conjugate to SN38 Is Highly Effective in Small Cell Lung Cancer
Table S1 from A Novel HSP90 Inhibitor–Drug Conjugate to SN38 Is Highly Effective in Small Cell Lung Cancer Open
Supplemental Table 1
View article: Supplementary Video S3 from Unexpected Activities in Regulating Ciliation Contribute to Off-target Effects of Targeted Drugs
Supplementary Video S3 from Unexpected Activities in Regulating Ciliation Contribute to Off-target Effects of Targeted Drugs Open
Supplementary Video S3. Time-lapse images of hTERT-RPE1-Arl13b-GFP cells starved in serum-free Opti-MEM for 48 hours, then incubated for 3 hours in 1 µM alisertib + 20% FBS.
View article: Supplementary Figure S2 from <i>Nedd9</i> Restrains Autophagy to Limit Growth of Early Stage Non–Small Cell Lung Cancer
Supplementary Figure S2 from <i>Nedd9</i> Restrains Autophagy to Limit Growth of Early Stage Non–Small Cell Lung Cancer Open
Histopathological assessment of KP and KPN lungs
View article: Supplementary Video S7 from Unexpected Activities in Regulating Ciliation Contribute to Off-target Effects of Targeted Drugs
Supplementary Video S7 from Unexpected Activities in Regulating Ciliation Contribute to Off-target Effects of Targeted Drugs Open
Supplementary Video S7. Time-lapse images of hTERT-RPE1-Arl13b-GFP cells starved in serum-free Opti-MEM for 48 hours, then incubated for 3 hours in 2.5 µM erlotinib + 20% FBS.
View article: Supplementary Table S2 from <i>Nedd9</i> Restrains Autophagy to Limit Growth of Early Stage Non–Small Cell Lung Cancer
Supplementary Table S2 from <i>Nedd9</i> Restrains Autophagy to Limit Growth of Early Stage Non–Small Cell Lung Cancer Open
Primers used for RT-PCR in study
View article: Supplementary Video S3 from Unexpected Activities in Regulating Ciliation Contribute to Off-target Effects of Targeted Drugs
Supplementary Video S3 from Unexpected Activities in Regulating Ciliation Contribute to Off-target Effects of Targeted Drugs Open
Supplementary Video S3. Time-lapse images of hTERT-RPE1-Arl13b-GFP cells starved in serum-free Opti-MEM for 48 hours, then incubated for 3 hours in 1 µM alisertib + 20% FBS.
View article: Data from Unexpected Activities in Regulating Ciliation Contribute to Off-target Effects of Targeted Drugs
Data from Unexpected Activities in Regulating Ciliation Contribute to Off-target Effects of Targeted Drugs Open
Purpose:For many tumors, signaling exchanges between cancer cells and other cells in their microenvironment influence overall tumor signaling. Some of these exchanges depend on expression of the primary cilium on nontransformed cell popula…
View article: Supplementary Figure S3 from <i>Nedd9</i> Restrains Autophagy to Limit Growth of Early Stage Non–Small Cell Lung Cancer
Supplementary Figure S3 from <i>Nedd9</i> Restrains Autophagy to Limit Growth of Early Stage Non–Small Cell Lung Cancer Open
Inhibition of FAK, SRC, or CAMKK in NSCLC cell lines
View article: Supplementary Figure S4 from <i>Nedd9</i> Restrains Autophagy to Limit Growth of Early Stage Non–Small Cell Lung Cancer
Supplementary Figure S4 from <i>Nedd9</i> Restrains Autophagy to Limit Growth of Early Stage Non–Small Cell Lung Cancer Open
IHC asessment of dKP and KPN lungs from drug-treated mice