Anna Nozza
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View article: Genetic analyses across cardiovascular traits: leveraging genetic correlations to empower locus discovery and prediction in common cardiovascular diseases
Genetic analyses across cardiovascular traits: leveraging genetic correlations to empower locus discovery and prediction in common cardiovascular diseases Open
View article: Effect of a single ultra processed meal on myocardial endothelial function, adenosine mediated effects and cognitive performances
Effect of a single ultra processed meal on myocardial endothelial function, adenosine mediated effects and cognitive performances Open
Consumption of ultra-processed foods has been linked to various adverse health effects; however, the mechanisms underlying these effects remain poorly understood. This study aimed to evaluate the impact of a single ultra-processed meal on …
View article: Oxygen supplementation in ambulatory patients with heart failure: a randomized proof-of-concept study
Oxygen supplementation in ambulatory patients with heart failure: a randomized proof-of-concept study Open
Aims The aims of this study were to describe the short-term effects of oxygen therapy on the physiological response and symptoms during ambulation in patients with chronic heart failure (HF). Methods and results In this pilot, cross-over, …
View article: Time-dependent Mitochondrial Remodeling in Experimental Atrial Fibrillation and Potential Therapeutic Relevance
Time-dependent Mitochondrial Remodeling in Experimental Atrial Fibrillation and Potential Therapeutic Relevance Open
BACKGROUND Changes in mitochondria have been implicated in atrial fibrillation (AF), but their manifestations and significance are poorly understood. Here, we studied changes in mitochondrial morphology and function during AF and assessed …
View article: Cardiorespiratory fitness in COPD and HF from the Fitness Registry and the Importance of Exercise: a National Database
Cardiorespiratory fitness in COPD and HF from the Fitness Registry and the Importance of Exercise: a National Database Open
Aims To better characterize functional consequences of the presence of COPD on cardiorespiratory fitness in patients with HF. Methods and results Patients with any clinical indication for cardiopulmonary exercise testing (CPET) were includ…
View article: Oxygen supplementation and cognitive function in long-COVID
Oxygen supplementation and cognitive function in long-COVID Open
Background Patients can experience persistent cognitive complaints and deficits in long-COVID. Inflammation and capillary damage may contribute to symptoms by interfering with tissue oxygenation. Methods This was an exploratory pilot cross…
View article: Impact of age on the predictive value of NT-proBNP in patients with diabetes mellitus stabilised after an acute coronary syndrome
Impact of age on the predictive value of NT-proBNP in patients with diabetes mellitus stabilised after an acute coronary syndrome Open
View article: Antithrombotic Management and Outcomes of Anterior ST-Elevation Myocardial Infarction With New-Onset Wall Motion Abnormalities in Men and Women
Antithrombotic Management and Outcomes of Anterior ST-Elevation Myocardial Infarction With New-Onset Wall Motion Abnormalities in Men and Women Open
View article: Rationale and Design of the Randomized Bayesian Multicenter COME-TAVI Trial in Patients With a New Onset Left Bundle Branch Block
Rationale and Design of the Randomized Bayesian Multicenter COME-TAVI Trial in Patients With a New Onset Left Bundle Branch Block Open
View article: A new prediction model for ventricular arrhythmias in arrhythmogenic right ventricular cardiomyopathy
A new prediction model for ventricular arrhythmias in arrhythmogenic right ventricular cardiomyopathy Open
Aims Arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVC) is characterized by ventricular arrhythmias (VAs) and sudden cardiac death (SCD). We aimed to develop a model for individualized prediction of incident VA/SCD in ARVC pa…
View article: Pattern of Atrial Fibrillation and Cognitive Function in Young Patients With Atrial Fibrillation and Low CHADS <sub>2</sub> Score: Insights From the BRAIN-AF Trial
Pattern of Atrial Fibrillation and Cognitive Function in Young Patients With Atrial Fibrillation and Low CHADS <sub>2</sub> Score: Insights From the BRAIN-AF Trial Open
View article: Colchicine for community-treated patients with COVID-19 (COLCORONA): a phase 3, randomised, double-blinded, adaptive, placebo-controlled, multicentre trial
Colchicine for community-treated patients with COVID-19 (COLCORONA): a phase 3, randomised, double-blinded, adaptive, placebo-controlled, multicentre trial Open
The Government of Quebec, the Bill & Melinda Gates Foundation, the National Heart, Lung, and Blood Institute of the US National Institutes of Health, the Montreal Heart Institute Foundation, the NYU Grossman School of Medicine, the Rudin F…
View article: Genetics of symptom remission in outpatients with COVID-19
Genetics of symptom remission in outpatients with COVID-19 Open
We conducted a genome-wide association study of time to remission of COVID-19 symptoms in 1723 outpatients with at least one risk factor for disease severity from the COLCORONA clinical trial. We found a significant association at 5p13.3 (…
View article: Genetics of symptom remission in outpatients with COVID-19
Genetics of symptom remission in outpatients with COVID-19 Open
We conducted a genome-wide association study of time to remission of COVID-19 symptoms in 1723 outpatients with at least one risk factor for disease severity from the COLCORONA clinical trial. We found a significant association at 5p13.3 (…
View article: Efficacy of Colchicine in Non-Hospitalized Patients with COVID-19
Efficacy of Colchicine in Non-Hospitalized Patients with COVID-19 Open
Background Evidence suggests the role of an inflammatory storm in COVID-19 complications. Colchicine is an orally administered, anti-inflammatory medication beneficial in gout, pericarditis and coronary disease. Methods We performed a rand…
View article: <p>Injection of Bupivacaine into the Pleural and Mediastinal Drains: A Novel Approach for Decreasing Incident Pain After Cardiac Surgery – Montreal Heart Institute Experience</p>
Injection of Bupivacaine into the Pleural and Mediastinal Drains: A Novel Approach for Decreasing Incident Pain After Cardiac Surgery – Montreal Heart Institute Experience Open
This technique is a powerful, safe, and efficient tool in the armamentarium of pain management and its growing use within our institution has provided a substantial benefit in the treatment of early post-operative pain.
View article: Articles to Appear in Future Issues
Articles to Appear in Future Issues Open
View article: A disease-specific comorbidity index for predicting mortality in patients admitted to hospital with a cardiac condition
A disease-specific comorbidity index for predicting mortality in patients admitted to hospital with a cardiac condition Open
The cardiac-specific comorbidity index predicted in-hospital and 1-year death and length of stay in cardiovascular populations better than existing generic models. This novel index may be useful for research of cardiology outcomes performe…
View article: Retracted and Republished: A new prediction model for ventricular arrhythmias in arrhythmogenic right ventricular cardiomyopathy
Retracted and Republished: A new prediction model for ventricular arrhythmias in arrhythmogenic right ventricular cardiomyopathy Open
Using the largest cohort of patients with ARVC and no prior VA, a prediction model using readily available clinical parameters was devised to estimate VA risk and guide decisions regarding primary prevention ICDs (www.arvcrisk.com).
View article: Adiponectin, Free Fatty Acids, and Cardiovascular Outcomes in Patients With Type 2 Diabetes and Acute Coronary Syndrome
Adiponectin, Free Fatty Acids, and Cardiovascular Outcomes in Patients With Type 2 Diabetes and Acute Coronary Syndrome Open
OBJECTIVE In observational cohorts, adiponectin is inversely associated and free fatty acids (FFAs) are directly associated with incident coronary heart disease (CHD). Adiponectin tends to be reduced and FFAs elevated in type 2 diabetes. W…
View article: Articles to Appear in Future Issues (update)
Articles to Appear in Future Issues (update) Open
View article: Homeostasis Model Assessment of Insulin Resistance and Survival in Patients With Diabetes and Acute Coronary Syndrome
Homeostasis Model Assessment of Insulin Resistance and Survival in Patients With Diabetes and Acute Coronary Syndrome Open
Objective Insulin resistance has been linked to development and progression of atherosclerosis and is present in most patients with type 2 diabetes. Whether the degree of insulin resistance predicts adverse outcomes in patients with type 2…
View article: Predictors of mortality in hospital survivors with type 2 diabetes mellitus and acute coronary syndromes
Predictors of mortality in hospital survivors with type 2 diabetes mellitus and acute coronary syndromes Open
Aim: To define the predictors of long-term mortality in patients with type 2 diabetes mellitus and recent acute coronary syndrome. Methods and results: A total of 7226 patients from a randomized trial, testing the effect on cardiovascular …