Anna P. Kipp
YOU?
Author Swipe
Interaction of serum zinc and copper status with fatty acid desaturases on incidence of type 2 diabetes in the EPIC-Potsdam study Open
Zn and Cu status modified the relationship between FA desaturases and T2D risk. This was supported by serum Zn and Cu levels and by genetic variation related to their transport and homeostasis.
Distribution interactions of the trace elements zinc, copper, and selenium under conditions of their parallel deficiency Open
Trace elements such as copper, zinc, and selenium are essential micronutrients that play crucial roles in various physiological processes, mainly through their involvement in enzymes and regulatory proteins. A deficiency of any of these el…
View article: Vitamin A acts as a potent suppressor of selenoprotein P with potential relevance for multivitamin supplementation
Vitamin A acts as a potent suppressor of selenoprotein P with potential relevance for multivitamin supplementation Open
Multivitamin supplementation is a widely used strategy to prevent disease, slow the ageing process, improve quality of life and extend life span, although recent clinical findings do not support these claims. Since selenium (Se) deficiency…
View article: Nutritional care in metastatic RCC: patient experiences and reported unaddressed needs
Nutritional care in metastatic RCC: patient experiences and reported unaddressed needs Open
Purpose Although renal cell carcinoma (RCC) presents unique nutritional challenges due to the disease itself and treatment side effects, little is known about the prevalence of nutritional issues among RCC patients in a real-world setting.…
Selenium, zinc, and copper intake and status of vegetarian, vegan, and omnivore children and adolescents: results of the VeChi youth study Open
Purpose As animal-derived foods are the main source of selenium, zinc, and copper, children and adolescents on vegetarian or vegan dietary patterns are at risk of an inadequate supply. Methods Among 342 children and adolescents (6–18 years…
Supranutritional Selenomethionine but not Selenite Reduces Malignant Cell Transformation Open
The trace element selenium is essential to human health and has long been discussed to modulate the carcinogenic process. So far, the functions of selenium and selenoproteins have been mainly studied in already transformed cancer cells. Th…
Trace Elements and Genomic Instability in the Murine Brain Open
The trace elements copper, iron, manganese, selenium and zinc are essential micronutrients involved in various cellular processes, all with different responsibilities. Based on that importance, their concentrations are tightly regulated in…
Connecting concentrations of copper, selenium, and zinc with transcriptomic and proteomic data of well-characterized human colorectal cancer cell lines Open
Herein we identify gene signatures associated with intracellular copper and zinc concentrations in CRC cell lines. Extrapolating these signatures to primary colorectal tumors revealed that they can inform outcome of CRC patients.
Improving the selenium supply of vegans and omnivores with Brazil nut butter compared to a dietary supplement in a randomized controlled trial Open
Purpose A vegan diet is associated with health benefits but may also lead to inadequate intake of essential nutrients. Due to the lower selenium content in plant-based compared to animal-based foods, many vegans do not reach the recommende…
Revealing mercury species-specific transfer and toxicity mechanisms in placental trophoblasts Open
Environmental mercury (Hg) follows a biogeochemical cycle resulting in a variety of Hg species. Therefore, human exposure to the three Hg species inorganic Hg via crops and air, methyl Hg through fish consumption and ethyl Hg due to the us…
α‐Tocopherol Long‐Chain Metabolite α‐T‐13′‐COOH Exhibits Biphasic Effects on Cell Viability, Induces ROS‐Dependent DNA Damage, and Modulates Redox Status in Murine RAW264.7 Macrophages Open
Scope The α‐tocopherol long‐chain metabolite α‐tocopherol‐13′‐hydroxy‐chromanol (α‐T‐13′‐COOH) is a proposed regulatory intermediate of endogenous vitamin E metabolism. Effects of α‐T‐13′‐COOH on cell viability and adaptive stress response…
NRF2 and Thioredoxin Reductase 1 as Modulators of Interactions between Zinc and Selenium Open
Background: Selenium and zinc are essential trace elements known to regulate cellular processes including redox homeostasis. During inflammation, circulating selenium and zinc concentrations are reduced in parallel, but underlying mechanis…
Selenium-Enriched E. coli Bacteria Mitigate the Age-Associated Degeneration of Cholinergic Neurons in C. elegans Open
Selenium (Se) is an essential trace element for humans and animals, but high-dose supplementation with Se compounds, most notably selenite, may exert cytotoxic and other adverse effects. On the other hand, bacteria, including Escherichia c…
Determination of copper status by five biomarkers in serum of healthy women Open
This study suggests that the non-CP-bound copper species represent copper pools that are differently regulated from total copper or CP-bound copper, making them interesting complementary biomarkers to enable a more complete assessment of b…
View article: Long-term suboptimal dietary trace element supply does not affect trace element homeostasis in murine cerebellum
Long-term suboptimal dietary trace element supply does not affect trace element homeostasis in murine cerebellum Open
The ageing process is associated with alterations of systemic trace element (TE) homeostasis increasing the risk, e.g. neurodegenerative diseases. Here, the impact of long-term modulation of dietary intake of copper, iron, selenium, and zi…
Temporal dynamics of muscle mitochondrial uncoupling-induced integrated stress response and ferroptosis defense Open
Mitochondria play multifaceted roles in cellular function, and impairments across domains of mitochondrial biology are known to promote cellular integrated stress response (ISR) pathways as well as systemic metabolic adaptations. However, …
Selenium, Zinc, and Copper Status of Vegetarians and Vegans in Comparison to Omnivores in the Nutritional Evaluation (NuEva) Study Open
Plant-based diets usually contain more nutrient-dense foods such as vegetables, legumes, whole grains, and fruits than a standard Western diet. Yet, the amount and especially the bioavailability of several nutrients, such as trace elements…
Data from GPx2 Suppression of H<sub>2</sub>O<sub>2</sub> Stress Links the Formation of Differentiated Tumor Mass to Metastatic Capacity in Colorectal Cancer Open
Colorectal tumorigenesis is accompanied by the generation of oxidative stress, but how this controls tumor development is poorly understood. Here, we studied how the H2O2-reducing enzyme glutathione peroxidase 2 (GPx2) regulates H2O2 stres…
Supplementary Figure Legends from GPx2 Suppression of H<sub>2</sub>O<sub>2</sub> Stress Links the Formation of Differentiated Tumor Mass to Metastatic Capacity in Colorectal Cancer Open
Supplementary Figure Legends. Legends for Supplementary Figures S1-S6.
Data from GPx2 Suppression of H<sub>2</sub>O<sub>2</sub> Stress Links the Formation of Differentiated Tumor Mass to Metastatic Capacity in Colorectal Cancer Open
Colorectal tumorigenesis is accompanied by the generation of oxidative stress, but how this controls tumor development is poorly understood. Here, we studied how the H2O2-reducing enzyme glutathione peroxidase 2 (GPx2) regulates H2O2 stres…
Supplementary Figure S5 from GPx2 Suppression of H<sub>2</sub>O<sub>2</sub> Stress Links the Formation of Differentiated Tumor Mass to Metastatic Capacity in Colorectal Cancer Open
Supplementary Figure S5. GPx2 expression in human colon tumor cohorts correlates with epithelial differentiation and low H2O2 stress.