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View article: Hepatic epithelioid Hemangioendothelioma presenting synchronously with hepatocellular carcinoma-a case report
Hepatic epithelioid Hemangioendothelioma presenting synchronously with hepatocellular carcinoma-a case report Open
Backgrounds: Primary hepatic epithelioid hemangioendothelioma (HEHE) is a rare neoplasm of vascular origin with varying biologic behavior, making it challenging to diagnose. Case presentation: We present a case of synchronous hepatocellula…
View article: Central Retinal Artery Occlusion Following Delayed Acute Retinal Necrosis Post-SARS-CoV- 2 Recovery: Clinical Practice and Literature Review
Central Retinal Artery Occlusion Following Delayed Acute Retinal Necrosis Post-SARS-CoV- 2 Recovery: Clinical Practice and Literature Review Open
This study investigates acute retinal necrosis (ARN) complicated by central retinal artery occlusion (CRAO) post-SARS-CoV-2 infection, a rare clinical scenario. It highlights the clinical characteristics and potential pathogenesis of this …
View article: Towards Trustworthy AI-Enabled Decision Support Systems: Validation of the Multisource AI Scorecard Table (MAST)
Towards Trustworthy AI-Enabled Decision Support Systems: Validation of the Multisource AI Scorecard Table (MAST) Open
The Multisource AI Scorecard Table (MAST) is a checklist tool to inform the design and evaluation of trustworthy AI systems based on the U.S. Intelligence Community’s analytic tradecraft standards. In this study, we investigate whether MAS…
View article: PADTHAI-MM: Principles-based Approach for Designing Trustworthy, Human-centered AI using MAST Methodology
PADTHAI-MM: Principles-based Approach for Designing Trustworthy, Human-centered AI using MAST Methodology Open
Despite an extensive body of literature on trust in technology, designing trustworthy AI systems for high-stakes decision domains remains a significant challenge, further compounded by the lack of actionable design and evaluation tools. Th…
View article: P642: Development and deployment of clinical genome sequencing using a cloud-based platform
P642: Development and deployment of clinical genome sequencing using a cloud-based platform Open
Genome-wide Sequencing Ontario (GSO) is a provincial platform designed to deliver clinical exome (ES) and genome (GS) sequencing for Ontarians with a suspected rare disease. The platform service, which is a partnership between CHEO (Childr…
View article: Evaluating Trustworthiness of AI-Enabled Decision Support Systems: Validation of the Multisource AI Scorecard Table (MAST)
Evaluating Trustworthiness of AI-Enabled Decision Support Systems: Validation of the Multisource AI Scorecard Table (MAST) Open
The Multisource AI Scorecard Table (MAST) is a checklist tool based on analytic tradecraft standards to inform the design and evaluation of trustworthy AI systems. In this study, we evaluate whether MAST is associated with people's trust p…
View article: IL-6 Promotes Hepatocellular Carcinoma Invasion by Releasing Exosomal miR-133a-3p
IL-6 Promotes Hepatocellular Carcinoma Invasion by Releasing Exosomal miR-133a-3p Open
Interleukin-6 (IL-6), an important inflammatory cytokine, is a key factor regulating cancer metastasis. Cancer cells can modulate their tumorigenic abilities by sorting specific microRNAs (miRNAs) as exosomes into the tumor microenvironmen…
View article: Patched Domain-containing 4 (PTCH53) Identified in Li-Fraumeni Syndrome Patient-derived Cells
Patched Domain-containing 4 (PTCH53) Identified in Li-Fraumeni Syndrome Patient-derived Cells Open
Germline TP53 mutations are the primary underlying etiologic cause of Li-Fraumeni syndrome. Lack of predictability in age-of-onset, cancer phenotypes, and likelihood of subsequent malignancies, highlights the need to understand secondary m…
View article: ATRT-13. CANCER PREDISPOSITION AMONG CHILDREN WITH RHABDOID TUMORS: A SINGLE-CENTRE RETROSPECTIVE REVIEW
ATRT-13. CANCER PREDISPOSITION AMONG CHILDREN WITH RHABDOID TUMORS: A SINGLE-CENTRE RETROSPECTIVE REVIEW Open
BACKGROUND: Rhabdoid tumor predisposition syndrome (RTPS) from SMARCB1 germline mutations must be ruled out in children with rhabdoid tumors (RT). The aim was to describe the diagnostic details of children with RT, genetic referral practic…
View article: A novel system for predicting liver histopathology in patients with chronic hepatitis B
A novel system for predicting liver histopathology in patients with chronic hepatitis B Open
There is currently a lack of reliable, reproducible, and easily applied methods for assessing changes in liver histology in patients in the gray zone phase of chronic hepatitis B (CHB). Therefore, we aimed to develop a novel predictive sco…
View article: Transcriptome-wide characterization of the endogenous miR-34A-p53 tumor suppressor network
Transcriptome-wide characterization of the endogenous miR-34A-p53 tumor suppressor network Open
microRNA-34A is a critical component of the p53 network and expression of miR- 34A is down-regulated by promoter hypermethylation or focal deletions in numerous human cancers. Although miR-34A deregulation may be an important driver in can…