Anna Pastore
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View article: P12.34.A TRACKING INDIVIDUAL AND COLLECTIVE CELLULAR DIFFUSION IN PATIENT-DERIVED PRIMARY GBM CELL LINES: EXPLORING CELL DIFFUSION PROPERTIES AS A POTENTIAL VULNERABILITY IN GLIOBLASTOMA
P12.34.A TRACKING INDIVIDUAL AND COLLECTIVE CELLULAR DIFFUSION IN PATIENT-DERIVED PRIMARY GBM CELL LINES: EXPLORING CELL DIFFUSION PROPERTIES AS A POTENTIAL VULNERABILITY IN GLIOBLASTOMA Open
BACKGROUND Glioblastoma (GBM) is one of the most aggressive and deadly brain tumors, with a median survival of ~14 months. Its poor prognosis is largely due to its ability to infiltrate healthy brain tissue both as single cells and in coll…
View article: Peroxisome Proliferator-Activated Receptor Family of Lipid-Activated Nuclear Receptors Alpha Silencing Promotes Oxidative Stress and Hypertrophic Phenotype in Rat Cardiac Cells
Peroxisome Proliferator-Activated Receptor Family of Lipid-Activated Nuclear Receptors Alpha Silencing Promotes Oxidative Stress and Hypertrophic Phenotype in Rat Cardiac Cells Open
The peroxisome proliferator-activated receptor family of lipid-activated nuclear receptors (PPARs) plays a critical role in the regulation of cellular lipid metabolism. In cardiac muscle, PPARα is highly expressed and regulates genes invol…
View article: Peroxisome Proliferator-Activated Receptor Family of Lipid-Activated Nuclear Receptors Alpha Silencing Promotes Oxidative Stress and Hypertrophic Phenotype in Rat Cardiac Cells
Peroxisome Proliferator-Activated Receptor Family of Lipid-Activated Nuclear Receptors Alpha Silencing Promotes Oxidative Stress and Hypertrophic Phenotype in Rat Cardiac Cells Open
The peroxisome proliferator-activated receptor family of lipid-activated nuclear receptors (PPARs) plays a critical role in the regulation of cellular lipid metabolism. In cardiac muscle, PPARα is highly expressed and regulates genes invol…
View article: Levels of Growth Differentiation Factor 15 Correlated with Metabolic Dysfunction-Associated Steatotic Liver Disease in Children
Levels of Growth Differentiation Factor 15 Correlated with Metabolic Dysfunction-Associated Steatotic Liver Disease in Children Open
Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common chronic progressive hepatopathy in children, and the identification of non-invasive biomarkers is urgently needed. Growth differentiation factor 15 (GDF15)…
View article: The interplay between oxidative stress and inflammation supports autistic-related behaviors in Cntnap2 knockout mice
The interplay between oxidative stress and inflammation supports autistic-related behaviors in Cntnap2 knockout mice Open
Autism Spectrum Disorder (ASD) is a highly prevalent neurodevelopmental condition characterized by social communication deficits and repetitive/restricted behaviors. Several studies showed that oxidative stress and inflammation may contrib…
View article: Alterations in Glutathione Redox Homeostasis in Metabolic Dysfunction-Associated Fatty Liver Disease: A Systematic Review
Alterations in Glutathione Redox Homeostasis in Metabolic Dysfunction-Associated Fatty Liver Disease: A Systematic Review Open
Low molecular weight (LMW) thiols, particularly glutathione, play pathogenic roles in various multiorgan diseases. The liver is central for the production and systemic distribution of LMW thiols; thus, it is particularly susceptible to the…
View article: N-Acetylcysteine Counteracts Immune Dysfunction and Autism-Related Behaviors in the Shank3b Mouse Model of Autism Spectrum Disorder
N-Acetylcysteine Counteracts Immune Dysfunction and Autism-Related Behaviors in the Shank3b Mouse Model of Autism Spectrum Disorder Open
Autism spectrum disorder (ASD) includes a range of neurodevelopmental disabilities characterized by social interaction deficits, communication impairments, and repetitive behaviors. Previous studies have shown that pro-inflammatory conditi…
View article: P08.02.B BEYOND THE EXPECTED: CIRCULATING TUMOR CELLS IN GLIOBLASTOMA REVEAL HIDDEN HETEROGENEITY AND BECOME POTENTIAL DIAGNOSTIC BIOMARKERS
P08.02.B BEYOND THE EXPECTED: CIRCULATING TUMOR CELLS IN GLIOBLASTOMA REVEAL HIDDEN HETEROGENEITY AND BECOME POTENTIAL DIAGNOSTIC BIOMARKERS Open
BACKGROUND For many years, glioblastoma (GBM) was thought to be restricted to the brain. Nevertheless, a growing body of evidence indicates that, like many other cancers, hematogenic dissemination is a reality. Detection of circulating tum…
View article: OS07.8.A INNOVATIVE DYNAMIC STRATIFICATION IN GLIOBLASTOMA: ANALYZING TUMOR CELL CHARACTERISTICS AND MOBILITY STRATEGIES THROUGH SINGLE CELL BEHAVIOR LIVE IMAGING (SCBLI)
OS07.8.A INNOVATIVE DYNAMIC STRATIFICATION IN GLIOBLASTOMA: ANALYZING TUMOR CELL CHARACTERISTICS AND MOBILITY STRATEGIES THROUGH SINGLE CELL BEHAVIOR LIVE IMAGING (SCBLI) Open
BACKGROUND Glioblastoma, a highly aggressive brain tumor, presents a daunting prognosis with an average survival of under 15 months due to its invasive nature. Understanding the specific behaviors of individual tumor cells in terms of volu…
View article: N-acetylcysteine counteracts immune dysfunction and autistic-related behaviors in the<i>Shank3b</i>mouse model of Autism Spectrum Disorders
N-acetylcysteine counteracts immune dysfunction and autistic-related behaviors in the<i>Shank3b</i>mouse model of Autism Spectrum Disorders Open
Autism Spectrum Disorder (ASD) includes a range of neurodevelopmental disabilities characterized by social interaction deficits, communication impairments, and repetitive behaviors. Previous studies have shown that pro-inflammatory conditi…
View article: The interplay between oxidative stress and inflammation supports autistic-related behaviors in mice
The interplay between oxidative stress and inflammation supports autistic-related behaviors in mice Open
Autism Spectrum Disorder (ASD) is a highly prevalent neurodevelopmental condition characterized by social communication deficits and repetitive/restricted behaviors. Several studies showed that inflammation may contribute to ASD. Here we u…
View article: P10.10.B BIRC3 AS A PREDICTOR OF OUTCOME AND A NEW THERAPEUTIC TARGET IN TMZ RESISTANT GLIOBLASTOMA TUMORS
P10.10.B BIRC3 AS A PREDICTOR OF OUTCOME AND A NEW THERAPEUTIC TARGET IN TMZ RESISTANT GLIOBLASTOMA TUMORS Open
BACKGROUND Glioblastoma (GB) is the most aggressive malignant tumor of the central nervous system, with a highly unfavorable prognosis with a median survival of 15 months. The standard treatment consists of surgical resection, chemotherapy…
View article: Plasminogen Activator Inhibitor-1 and Vitamin D Association in the Overweight and Obese Pediatric Population
Plasminogen Activator Inhibitor-1 and Vitamin D Association in the Overweight and Obese Pediatric Population Open
Background: Childhood overweight and obesity have been described by the World Health Organization as noncommunicable diseases and among the greatest public health threats since they have reached epidemic proportions. A child with obesity r…
View article: BIRC3: A Prognostic Predictor and Novel Therapeutic Target in TMZ-Resistant Glioblastoma Tumors
BIRC3: A Prognostic Predictor and Novel Therapeutic Target in TMZ-Resistant Glioblastoma Tumors Open
Background Glioblastoma (GB) is an incurable malignant tumor of the central nervous system, with a poor prognosis. Robust molecular biomarkers associated with therapeutic response or survival are still lacking in GB. Previously, using NADH…
View article: Spermine oxidase induces DNA damage and sensitizes fusion negative rhabdomyosarcoma cells to irradiation
Spermine oxidase induces DNA damage and sensitizes fusion negative rhabdomyosarcoma cells to irradiation Open
Rhabdomyosarcoma (RMS) is a pediatric myogenic soft tissue sarcoma that includes fusion-positive (FP) and fusion-negative (FN) molecular subtypes. FP-RMS expresses PAX3-FOXO1 fusion protein and often shows dismal prognosis. FN-RMS shows cy…
View article: Study of the Association between Thiols and Oxidative Stress Markers in Children with Obesity
Study of the Association between Thiols and Oxidative Stress Markers in Children with Obesity Open
Obesity has reached epidemic proportions, and the World Health Organization defined childhood overweight and obesity as a noncommunicable disease that represents the most serious public health challenges of the twenty-first century. Oxidat…
View article: Hydroxytyrosol Recovers SARS-CoV-2-PLpro-Dependent Impairment of Interferon Related Genes in Polarized Human Airway, Intestinal and Liver Epithelial Cells
Hydroxytyrosol Recovers SARS-CoV-2-PLpro-Dependent Impairment of Interferon Related Genes in Polarized Human Airway, Intestinal and Liver Epithelial Cells Open
The SARS-CoV-2 pandemic has caused approximately 6.3 million deaths, mainly due to the acute respiratory distress syndrome or multi-organ failure that characterizes COVID-19 acute disease. Post-acute COVID-19 syndrome, also known as long-C…
View article: Drug Repurposing in Rare Diseases: An Integrative Study of Drug Screening and Transcriptomic Analysis in Nephropathic Cystinosis
Drug Repurposing in Rare Diseases: An Integrative Study of Drug Screening and Transcriptomic Analysis in Nephropathic Cystinosis Open
Diagnosis and cure for rare diseases represent a great challenge for the scientific community who often comes up against the complexity and heterogeneity of clinical picture associated to a high cost and time-consuming drug development pro…
View article: Benefits and Toxicity of Disulfiram in Preclinical Models of Nephropathic Cystinosis
Benefits and Toxicity of Disulfiram in Preclinical Models of Nephropathic Cystinosis Open
Nephropathic cystinosis is a rare disease caused by mutations of the CTNS gene that encodes for cystinosin, a lysosomal cystine/H+ symporter. The disease is characterized by early-onset chronic kidney failure and progressive development of…
View article: Cerebrospinal Fluid Levels of AFP and hCG: Validation of the Analytical Method and Application in the Diagnosis of Central Nervous System Germ Cell Tumors
Cerebrospinal Fluid Levels of AFP and hCG: Validation of the Analytical Method and Application in the Diagnosis of Central Nervous System Germ Cell Tumors Open
The determination of Human Chorionic Gonadotropin (hCG) and Alpha Fetoprotein (AFP) levels on serum and amniotic fluid plays a fundamental role in the diagnosis and follow-up of specific physiological or pathological conditions (e.g., preg…
View article: Focal adhesion kinase inhibitor TAE226 combined with Sorafenib slows down hepatocellular carcinoma by multiple epigenetics effects
Focal adhesion kinase inhibitor TAE226 combined with Sorafenib slows down hepatocellular carcinoma by multiple epigenetics effects Open
Background Hepatocellular carcinoma (HCC) is one of the most common and lethal malignant tumours worldwide. Sorafenib (SOR) is one of the most effective single-drug systemic therapy against advanced HCC, but the identification of novel com…
View article: Additional file 4 of Focal adhesion kinase inhibitor TAE226 combined with Sorafenib slows down hepatocellular carcinoma by multiple epigenetic effects
Additional file 4 of Focal adhesion kinase inhibitor TAE226 combined with Sorafenib slows down hepatocellular carcinoma by multiple epigenetic effects Open
Additional file 4: Table S4. Nuclear interactors of FAK.
View article: A novel disorder involving dyshematopoiesis, inflammation, and HLH due to aberrant CDC42 function
A novel disorder involving dyshematopoiesis, inflammation, and HLH due to aberrant CDC42 function Open
Hemophagocytic lymphohistiocytosis (HLH) is characterized by immune dysregulation due to inadequate restraint of overactivated immune cells and is associated with a variable clinical spectrum having overlap with more common pathophysiologi…