Anna Pees
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View article: Sex- and age-specific sensitivities of the endocannabinoid system in Alzheimer's disease revealed by PET imaging with [<sup>18</sup>F]FMPEP-<i>d</i><sub>2</sub> and [<sup>18</sup>F]MAGL-2102
Sex- and age-specific sensitivities of the endocannabinoid system in Alzheimer's disease revealed by PET imaging with [<sup>18</sup>F]FMPEP-<i>d</i><sub>2</sub> and [<sup>18</sup>F]MAGL-2102 Open
The endocannabinoid system is a critical brain signaling pathway that is dysregulated in various brain disorders, including Alzheimer's disease (AD). Cannabinoid-targeted therapies and imaging approaches have gained increasing interest; ho…
View article: Development of Pyridothiophene Compounds for PET Imaging of α‐Synuclein
Development of Pyridothiophene Compounds for PET Imaging of α‐Synuclein Open
Aggregated α‐synuclein (α‐syn) protein is a pathological hallmark of Parkinson's disease (PD) and Lewy body dementia (LBD). Development of positron emission tomography (PET) radiotracers to image α‐syn aggregates has been a longstanding go…
View article: Spirocyclic Iodonium Ylides for Fluorine‐18 Radiolabeling of Non‐Activated Arenes: From Concept to Clinical Research
Spirocyclic Iodonium Ylides for Fluorine‐18 Radiolabeling of Non‐Activated Arenes: From Concept to Clinical Research Open
Positron emission tomography (PET) is a powerful imaging tool for drug discovery, clinical diagnosis, and monitoring of disease progression. Fluorine‐18 is the most common radionuclide used for PET, but advances in radiotracer development …
View article: Recent Developments in Carbon-11 Chemistry and Applications for First-In-Human PET Studies
Recent Developments in Carbon-11 Chemistry and Applications for First-In-Human PET Studies Open
Positron emission tomography (PET) is a molecular imaging technique that makes use of radiolabelled molecules for in vivo evaluation. Carbon-11 is a frequently used radionuclide for the labelling of small molecule PET tracers and can be in…
View article: Evaluating <i>N</i>‐difluoromethyltriazolium triflate as a precursor for the synthesis of high molar activity [<sup>18</sup>F]fluoroform
Evaluating <i>N</i>‐difluoromethyltriazolium triflate as a precursor for the synthesis of high molar activity [<sup>18</sup>F]fluoroform Open
The trifluoromethyl group is a prominent motif in biologically active compounds and therefore of great interest for the labeling with the positron emitter fluorine‐18 for positron emission tomography (PET) imaging. Multiple labeling strate…
View article: Fluorine-18 labelled Ruppert–Prakash reagent ([<sup>18</sup>F]Me<sub>3</sub>SiCF<sub>3</sub>) for the synthesis of <sup>18</sup>F-trifluoromethylated compounds
Fluorine-18 labelled Ruppert–Prakash reagent ([<sup>18</sup>F]Me<sub>3</sub>SiCF<sub>3</sub>) for the synthesis of <sup>18</sup>F-trifluoromethylated compounds Open
The radiolabelling of Ruppert–Prakash reagent with fluorine-18 was developed and applied in the [18F]trifluoromethylation of benzaldehydes, acetophenones and benzophenones.
View article: Synthesis of [<sup>18</sup>F]Fluoroform with High Molar Activity
Synthesis of [<sup>18</sup>F]Fluoroform with High Molar Activity Open
Fluoroform is an interesting motif for the isotopologue labelling of biologically active compounds with fluorine‐18 for PET imaging. However, so far the building block [ 18 F]fluoroform and consequently the [ 18 F]trifluoromethylated produ…
View article: Correction: Fast and reliable generation of [<sup>18</sup>F]triflyl fluoride, a gaseous [<sup>18</sup>F]fluoride source
Correction: Fast and reliable generation of [<sup>18</sup>F]triflyl fluoride, a gaseous [<sup>18</sup>F]fluoride source Open
Correction for ‘Fast and reliable generation of [18F]triflyl fluoride, a gaseous [18F]fluoride source’ by A. Pees et al., Chem. Commun., 2018, 54, 10179–10182.
View article: Fast and reliable generation of [<sup>18</sup>F]triflyl fluoride, a gaseous [<sup>18</sup>F]fluoride source
Fast and reliable generation of [<sup>18</sup>F]triflyl fluoride, a gaseous [<sup>18</sup>F]fluoride source Open
Reactive [18F]fluoride was generated from gaseous [18F]triflyl fluoride and used for a wide range of radiofluorination reactions.
View article: Risk factors for inadequate antibody response to primary rabies vaccination in dogs under one year of age
Risk factors for inadequate antibody response to primary rabies vaccination in dogs under one year of age Open
Ensuring the adequacy of response to rabies vaccination in dogs is important, particularly in the context of pet travel. Few studies have examined the factors associated with dogs' failure to achieve an adequate antibody titer after vaccin…
View article: Fluorine-18 labelled building blocks for PET tracer synthesis
Fluorine-18 labelled building blocks for PET tracer synthesis Open
This review presents a comprehensive overview of the synthesis and application of fluorine-18 labelled building blocks since 2010.