Anna Polosa
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View article: Sub-retinal transplantation of human iPSC-derived retinal sheets: A promising approach for the treatment of macular degeneration
Sub-retinal transplantation of human iPSC-derived retinal sheets: A promising approach for the treatment of macular degeneration Open
Retinal degenerative diseases affect millions of people worldwide, and legal blindness is generally associated with the loss of cone photoreceptors located in the retina’s central region called the macula. Currently, there is no treatment …
View article: Resting state electroretinography: An innovative approach to intrinsic retinal function monitoring
Resting state electroretinography: An innovative approach to intrinsic retinal function monitoring Open
The electroretinogram (ERG) represents the biopotential evoked by the retina in response to a light stimulus. The flash evoked ERG (fERG) is the ERG modality most frequently used clinically to diagnose and monitor retinal disorders. We her…
View article: AAV-mediated PEX1 gene augmentation improves visual function in the PEX1-Gly844Asp mouse model for mild Zellweger spectrum disorder
AAV-mediated PEX1 gene augmentation improves visual function in the PEX1-Gly844Asp mouse model for mild Zellweger spectrum disorder Open
Patients with Zellweger spectrum disorder (ZSD) commonly present with vision loss due to mutations in PEX genes required for peroxisome assembly and function. Here, we evaluate PEX1 retinal gene augmentation therapy in a mouse model of mil…
View article: Evidences Suggesting that Distinct Immunological and Cellular Responses to Light Damage Distinguishes Juvenile and Adult Rat Retinas
Evidences Suggesting that Distinct Immunological and Cellular Responses to Light Damage Distinguishes Juvenile and Adult Rat Retinas Open
To unravel the mechanisms behind the higher resistance to light damage of juvenile (JR) versus adult (AR) rats, Sprague Dawley rats were exposed to a bright luminous environment of 10, 000 lux. The light-induced retinopathy (LIR) was asses…
View article: AB012. Retinopathy in a mouse model for Zellweger spectrum disorder
AB012. Retinopathy in a mouse model for Zellweger spectrum disorder Open
Background: Zellweger spectrum disorder (ZSD) is an autosomal recessive disease caused by mutations in any one of 13 PEX genes whose protein products are required for peroxisome assembly. Retinopathy leading to blindness is one of the majo…
View article: Light-Induced Retinopathy: Young Age Protects more than Ocular Pigmentation
Light-Induced Retinopathy: Young Age Protects more than Ocular Pigmentation Open
Purpose: The purpose of this study was to compare the efficacy that ocular melanin confers in protecting the retina of juvenile and adult rats exposed to a bright luminous environment. Methods: Juvenile (JLE) and adult (ALE) Long–Evans pig…
View article: Strain Differences in Light-Induced Retinopathy
Strain Differences in Light-Induced Retinopathy Open
The purpose of this study was to better understand the role of ocular pigmentation and genetics in light-induced retinal damage. Adult pigmented [Long Evans (LE) and Brown Norway (BN)] and albino [Sprague Dawley (SD) and Lewis (LW)] rats w…
View article: Retinotopic Distribution of Structural and Functional Damages following Bright Light Exposure of Juvenile Rats
Retinotopic Distribution of Structural and Functional Damages following Bright Light Exposure of Juvenile Rats Open
In the present study, we aimed at better understanding the short (acute) and long term (chronic) degenerative processes characterizing the juvenile rat model of light-induced retinopathy. Electroretinograms, visual evoked potentials (VEP),…
View article: Characterizing the Retinal Function of Psammomys obesus: A Diurnal Rodent Model to Study Human Retinal Function
Characterizing the Retinal Function of Psammomys obesus: A Diurnal Rodent Model to Study Human Retinal Function Open
Purpose: To compare the retinal function of a diurnal murid rodent, Psammomys obesus, with that of Wistar albino rat and human subjects.Materials and methods: Adult Psammomys obesus were captured and transferred to the animal facilities wh…
View article: Differences in Retinal Structure and Function between Aging Male and Female Sprague-Dawley Rats are Strongly Influenced by the Estrus Cycle
Differences in Retinal Structure and Function between Aging Male and Female Sprague-Dawley Rats are Strongly Influenced by the Estrus Cycle Open
Our results showed that biological sex and age can influence the retinal function and structure of albino SD rats. Furthermore, we showed that cycled female rats have better retinal function compared to the menopausal female rats suggestin…