Andreas Probst
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View article: Artificial Intelligence‐assisted Endoscopy and Examiner Confidence: A Study on Human–Artificial Intelligence Interaction in Barrett's Esophagus (With Video)
Artificial Intelligence‐assisted Endoscopy and Examiner Confidence: A Study on Human–Artificial Intelligence Interaction in Barrett's Esophagus (With Video) Open
Objective Despite high stand‐alone performance, studies demonstrate that artificial intelligence (AI)‐supported endoscopic diagnostics often fall short in clinical applications due to human‐AI interaction factors. This video‐based trial on…
View article: Feasibility and benefit of decompressive percutaneous endoscopic gastrostomy (dPEG) in advanced cancer patients with malignant bowel obstruction
Feasibility and benefit of decompressive percutaneous endoscopic gastrostomy (dPEG) in advanced cancer patients with malignant bowel obstruction Open
Background and study aims Bowel obstruction is a common complication in advanced cancer patients. Patients are restricted in quality of life (QOL) due to nausea, vomiting, or abdominal pain. Prospective data on the feasibility and benefit …
View article: Endoscopic Submucosal Dissection for Early Gastric Cancer Exceeding Expanded Criteria—Long-Term Outcomes from the German ESD Registry
Endoscopic Submucosal Dissection for Early Gastric Cancer Exceeding Expanded Criteria—Long-Term Outcomes from the German ESD Registry Open
Background and aims: Endoscopic submucosal dissection (ESD) has become a standard treatment for early gastric cancer (EGC), often fulfilling guideline criteria (GC) or expanded criteria (EC). When lesions exceed the EC, surgical resection …
View article: Colorectal polypectomy and endoscopic mucosal resection: European Society of Gastrointestinal Endoscopy (ESGE) Guideline – Update 2024
Colorectal polypectomy and endoscopic mucosal resection: European Society of Gastrointestinal Endoscopy (ESGE) Guideline – Update 2024 Open
Main Recommendations 1 ESGE recommends cold snare polypectomy (CSP), to include a clear margin of normal tissue (1–2 mm) surrounding the polyp, for the removal of diminutive polyps (≤ 5 mm). Strong recommendation, high quality of evidence.…
View article: Influence of artificial intelligence on the diagnostic performance of endoscopists in the assessment of Barrett’s esophagus: a tandem randomized and video trial
Influence of artificial intelligence on the diagnostic performance of endoscopists in the assessment of Barrett’s esophagus: a tandem randomized and video trial Open
Background This study evaluated the effect of an artificial intelligence (AI)-based clinical decision support system on the performance and diagnostic confidence of endoscopists in their assessment of Barrett’s esophagus (BE). Methods 96 s…
View article: The Concept of Stroma AReactive Invasion Front Areas (SARIFA) as a New Prognostic Biomarker for Lipid-driven Cancers Holds True in Pancreatic Ductal Adenocarcinoma
The Concept of Stroma AReactive Invasion Front Areas (SARIFA) as a New Prognostic Biomarker for Lipid-driven Cancers Holds True in Pancreatic Ductal Adenocarcinoma Open
Background Pancreatic ductal adenocarcinoma (PDAC) is a ‘difficult-to-treat’ entity. To forecast its prognosis, we introduced a new biomarker, SARIFA (stroma areactive invasion front areas), which are an area at the tumour invasion front l…
View article: First report from the International Evaluation of Endoscopic classification Japan NBI Expert Team: International multicenter web trial
First report from the International Evaluation of Endoscopic classification Japan NBI Expert Team: International multicenter web trial Open
Objectives Narrow‐band imaging (NBI) contributes to real‐time optical diagnosis and classification of colorectal lesions. The Japan NBI Expert Team (JNET) was introduced in 2011. The aim of this study was to explore the diagnostic accuracy…
View article: Hemorrhagic Shock After Endoscopic Biopsy of Sigmoid Cancer: Pseudoaneurysm of the Rectal Superior Artery
Hemorrhagic Shock After Endoscopic Biopsy of Sigmoid Cancer: Pseudoaneurysm of the Rectal Superior Artery Open
An 86-year-old man without significant comorbidity presented with weight loss, diarrhea, and iron deficiency anemia. No signs of gastrointestinal bleeding were noticed. Colonoscopy was performed, and sigmoid cancer was suspected (a). Biops…
View article: Endoscopic submucosal dissection for superficial esophageal squamous cell carcinoma: long-term follow-up in a Western center
Endoscopic submucosal dissection for superficial esophageal squamous cell carcinoma: long-term follow-up in a Western center Open
Background/Aims: Endoscopic submucosal dissection (ESD) has been established as a treatment modality for superficial esophageal squamous cell carcinoma (ESCC). Long-term follow-up data are lacking in Western countries. The aim of this stud…
View article: Wide-area transepithelial sampling with computer-assisted analysis to detect high grade dysplasia and cancer in Barrettʼs esophagus: a multicenter randomized study
Wide-area transepithelial sampling with computer-assisted analysis to detect high grade dysplasia and cancer in Barrettʼs esophagus: a multicenter randomized study Open
Background Current surveillance for Barrett’s esophagus (BE), consisting of four-quadrant random forceps biopsies (FBs), has an inherent risk of sampling error. Wide-area transepithelial sampling (WATS) may increase detection of high grade…
View article: Vessel and tissue recognition during third-space endoscopy using a deep learning algorithm
Vessel and tissue recognition during third-space endoscopy using a deep learning algorithm Open
In this study, we aimed to develop an artificial intelligence clinical decision support solution to mitigate operator-dependent limitations during complex endoscopic procedures such as endoscopic submucosal dissection and peroral endoscopi…
View article: Multimodal imaging for detection and segmentation of Barrett’s esophagus-related neoplasia using artificial intelligence
Multimodal imaging for detection and segmentation of Barrett’s esophagus-related neoplasia using artificial intelligence Open
The early diagnosis of cancer in Barrett's esophagus is crucial for improving the prognosis. However, identifying Barrett's esophagus-related neoplasia (BERN) is challenging, even for experts [1]. Four-quadrant biopsies may improve the det…
View article: Stroma <scp>A</scp>Reactive <scp>I</scp>nvasion <scp>F</scp>ront <scp>A</scp>reas (<scp>SARIFA</scp>) – a new prognostic biomarker in gastric cancer related to tumor‐promoting adipocytes
Stroma <span>A</span>Reactive <span>I</span>nvasion <span>F</span>ront <span>A</span>reas (<span>SARIFA</span>) – a new prognostic biomarker in gastric cancer related to tumor‐promoting adipocytes Open
Compared to other malignancies, there is a lack of easy‐to‐evaluate biomarkers for gastric cancer, which is associated with an adverse clinical outcome in many cases. Here, we present S troma AR eactive I nvasion F ront A reas (SARIFA) as …
View article: Indications for endoscopic treatment of adenocarcinoma and squamous cell cancer of the esophagus
Indications for endoscopic treatment of adenocarcinoma and squamous cell cancer of the esophagus Open
: Endoscopic treatment of esophageal adenocarcinoma (EAC) and squamous cell cancer (ESCC) has gained importance over the last years. Early endoscopic detection has important prognostic and therapeutic implications because of the risk of ly…
View article: Update on ablative therapy for Barrett’s related dysplasia
Update on ablative therapy for Barrett’s related dysplasia Open
: Barrett’s esophagus (BE) is defined as intestinal metaplasia of the esophageal epithelium and represents the precursor lesion of esophageal adenocarcinoma (EAC), a rapidly increasing cancer in western countries. Metaplastic cells may dev…
Convolutional Neural Networks for the evaluation of cancer in Barrett's esophagus: Explainable AI to lighten up the black-box Open
Even though artificial intelligence and machine learning have demonstrated remarkable performances in medical image computing, their level of accountability and transparency must be provided in such evaluations. The reliability related to …
View article: Ultrastaging Using Ex Vivo Sentinel Lymph Node Mapping and One-Step Nucleic Acid Amplification (OSNA) in Gastric Cancer: Experiences of a European Center
Ultrastaging Using Ex Vivo Sentinel Lymph Node Mapping and One-Step Nucleic Acid Amplification (OSNA) in Gastric Cancer: Experiences of a European Center Open
Background: In this study, the effectiveness of One-step nucleic acid amplification (OSNA) in combination with ex vivo SLN mapping is compared with conventional histology including immunohistochemistry. Methods: LNs were retrieved from gas…
View article: Esophageal adenocarcinoma on esophageal varices – endoscopic resection after transjugular intrahepatic portosystemic shunt
Esophageal adenocarcinoma on esophageal varices – endoscopic resection after transjugular intrahepatic portosystemic shunt Open
Endoscopic resection is the first-choice therapy for T1a esophageal adenocarcinoma (EAC) [1]. In patients with liver cirrhosis, endoscopic resection might be difficult due to portal hypertension, esophageal varices, and coagulation disorde…
View article: Endoscopic prediction of submucosal invasion in Barrett’s cancer with the use of artificial intelligence: a pilot study
Endoscopic prediction of submucosal invasion in Barrett’s cancer with the use of artificial intelligence: a pilot study Open
Background The accurate differentiation between T1a and T1b Barrett’s-related cancer has both therapeutic and prognostic implications but is challenging even for experienced physicians. We trained an artificial intelligence (AI) system on …