Anna Ramisch
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View article: Genetic Landscape of the ACE2 Coronavirus Receptor
Genetic Landscape of the ACE2 Coronavirus Receptor Open
BACKGROUND: SARS-CoV-2, the causal agent of COVID-19, enters human cells using the ACE2 (angiotensin-converting enzyme 2) protein as a receptor. ACE2 is thus key to the infection and treatment of the coronavirus. ACE2 is highly expressed i…
View article: Chondrogenic Enhancer Landscape of Limb and Axial Skeleton Development
Chondrogenic Enhancer Landscape of Limb and Axial Skeleton Development Open
The precisely orchestrated differentiation of chondrocytes during skeleton development is a critical determinant of human height and body shape and disruptions of this process can cause severe skeletal abnormalities. The ultimate size and …
View article: Fear circuit–based neurobehavioral signatures mirror resilience to chronic social stress in mouse
Fear circuit–based neurobehavioral signatures mirror resilience to chronic social stress in mouse Open
Consistent evidence from human data points to successful threat–safety discrimination and responsiveness to extinction of fear memories as key characteristics of resilient individuals. To promote valid cross-species approaches for the iden…
View article: Proteomic analysis of 92 circulating proteins and their effects in cardiometabolic diseases
Proteomic analysis of 92 circulating proteins and their effects in cardiometabolic diseases Open
Background: Human plasma contains a wide variety of circulating proteins. These proteins can be important clinical biomarkers in disease and also possible drug targets. Large scale genomics studies of circulating proteins can identify gene…
View article: Leveraging interindividual variability of regulatory activity for refining genetic regulation of gene expression in schizophrenia
Leveraging interindividual variability of regulatory activity for refining genetic regulation of gene expression in schizophrenia Open
Schizophrenia is a polygenic psychiatric disorder with limited understanding about the mechanistic changes in gene expression regulation. To elucidate on this, we integrate interindividual variability of regulatory activity (ChIP-sequencin…
View article: Genetic variation in correlated regulatory regions of immunity
Genetic variation in correlated regulatory regions of immunity Open
Studying the interplay between genetic variation, epigenetic changes and regulation of gene expression in immune cells is important to understand the modification of cellular states in various conditions, including immune diseases. Here, w…
View article: Genetic variation in correlated regulatory region of Immunity
Genetic variation in correlated regulatory region of Immunity Open
Studying the interplay between genetic variation, epigenetic changes and regulation of gene expression in immune cells is important to understand the modification of cellular states in various conditions, including immune diseases. Here, w…
View article: Leveraging interindividual variability of regulatory activity refines genetic regulation of gene expression in schizophrenia
Leveraging interindividual variability of regulatory activity refines genetic regulation of gene expression in schizophrenia Open
Schizophrenia is a polygenic psychiatric disorder with limited understanding about the mechanistic changes in gene expression regulation. To elucidate on this, we integrate interindividual variability of regulatory activity with gene expre…
View article: Leveraging interindividual variability of regulatory activity refines genetic regulation of gene expression in schizophrenia
Leveraging interindividual variability of regulatory activity refines genetic regulation of gene expression in schizophrenia Open
Schizophrenia is a polygenic psychiatric disorder with limited understanding about the mechanistic changes in gene expression regulation. To elucidate on this, we integrate interindividual variability of regulatory activity with gene expre…
View article: The molecular basis, genetic control and pleiotropic effects of local gene co-expression
The molecular basis, genetic control and pleiotropic effects of local gene co-expression Open
Nearby genes are often expressed as a group. Yet, the prevalence, molecular mechanisms and genetic control of local gene co-expression are far from being understood. Here, by leveraging gene expression measurements across 49 human tissues …
View article: Enhancer Prediction Based on Epigenomic Data
Enhancer Prediction Based on Epigenomic Data Open
In this thesis, we show how to exploit the current knowledge of enhancers, and integrate different types of epigenomic data to make condition-specific predictions on the location of active enhancers. First, we introduce a novel method for …
View article: CRUP: A comprehensive framework to predict condition-specific regulatory units
CRUP: A comprehensive framework to predict condition-specific regulatory units Open
We present the software CRUP ( C ondition-specific R egulatory U nits P rediction) to infer from epigenetic marks a list of regulatory units consisting of dynamically changing enhancers with their target genes. The workflow consists of a n…
View article: Additional file 1: of Epigenomic profiling of non-small cell lung cancer xenografts uncover LRP12 DNA methylation as predictive biomarker for carboplatin resistance
Additional file 1: of Epigenomic profiling of non-small cell lung cancer xenografts uncover LRP12 DNA methylation as predictive biomarker for carboplatin resistance Open
Table S1. Clinical characteristics of the study cohort. Table S2. Response rates of PDXs to carboplatin treatment. Table S7. Carboplatin therapy resistance-associated genes for which promoter DNA methylation is correlated to tumor volume. …
View article: Predicting enhancers using a small subset of high confidence examples and co-training
Predicting enhancers using a small subset of high confidence examples and co-training Open
Enhancers are important regulatory regions located throughout the genome, primarily in non-coding regions. Several experimental methods have been developed over the last several years to identify their location, but the search space is lar…
View article: Predicting enhancers using a small subset of high confidence examples and co-training
Predicting enhancers using a small subset of high confidence examples and co-training Open
Enhancers are important regulatory regions located throughout the genome, primarily in non-coding regions. Several experimental methods have been developed over the last several years to identify their location, but the search space is lar…