Anna R. Hemnes
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View article: Real-World Experience with Selexipag in Patients with Pulmonary Arterial Hypertension: Treatment Patterns and Outcomes across Baseline Risk Strata (SPHERE and EXPOSURE Studies)
Real-World Experience with Selexipag in Patients with Pulmonary Arterial Hypertension: Treatment Patterns and Outcomes across Baseline Risk Strata (SPHERE and EXPOSURE Studies) Open
Despite current guidelines, over half of patients started selexipag almost 3 years after diagnosis, and 38% were already intermediate-high or high risk of 1-year mortality. Lower hospitalisation rates and better survival were observed for …
View article: Wnt5a-mediated Adipo-Cardiac Interorgan Communication in HFpEF
Wnt5a-mediated Adipo-Cardiac Interorgan Communication in HFpEF Open
Background Obesity is an important risk factor in heart failure with preserved ejection fraction (HFpEF), but the precise mechanisms that drive obesity-associated cardiac remodeling are not well understood. Our previous work has shown that…
View article: Pulmonary Artery Size on CT Associates with Mean Pulmonary Artery Pressure and Mortality
Pulmonary Artery Size on CT Associates with Mean Pulmonary Artery Pressure and Mortality Open
In subjects without significant lung disease outside of PH, PA size on CT was associated with increased mPAP and decreased transplant-free survival across the spectrum of PH severity and demonstrated modest diagnostic discriminatory abilit…
View article: American Lung Association Pulmonary Hypertension Roundtable: Executive Summary
American Lung Association Pulmonary Hypertension Roundtable: Executive Summary Open
The American Lung Association and Pulmonary Hypertension Association convened a scientific roundtable of pulmonary hypertension experts to discuss the latest recommendations from the European Guidelines for the Diagnosis and Treatment of P…
View article: The Surgical Management of Chronic Thromboembolic Pulmonary Hypertension
The Surgical Management of Chronic Thromboembolic Pulmonary Hypertension Open
Chronic thromboembolic pulmonary hypertension (CTEPH) is a type of pulmonary hypertension due to unresolved thromboembolic disease that presents with signs of pulmonary artery obstruction and right heart dysfunction. Pulmonary thromboendoa…
View article: Incidence and Clinical Associations With Phenotypic Drift From Pulmonary Arterial Hypertension to Combined Precapillary and Postcapillary Pulmonary Hypertension
Incidence and Clinical Associations With Phenotypic Drift From Pulmonary Arterial Hypertension to Combined Precapillary and Postcapillary Pulmonary Hypertension Open
Background: Pulmonary hypertension (PH) diagnosis relies on hemodynamic measurements from right heart catheterization (RHC). Pulmonary arterial hypertension (PAH) (group 1) is differentiated from group 2 PH (due to left-sided heart disease…
View article: Circular RNA Profiling Identifies <i>circ5078</i> as a <i>BMPR2</i> -Derived Regulator of Endothelial Proliferation and Stress Responses
Circular RNA Profiling Identifies <i>circ5078</i> as a <i>BMPR2</i> -Derived Regulator of Endothelial Proliferation and Stress Responses Open
BACKGROUND: The BMPR2 gene encodes the BMPR-II (bone morphogenetic protein receptor type-II) and is a known regulator of endothelial proliferation, apoptosis, and translational stress responses. While these effects are generally attributed…
View article: Characteristics of Patients with Pulmonary Arterial Hypertension Receiving Selexipag in the SPHERE Registry by Race and Ethnicity
Characteristics of Patients with Pulmonary Arterial Hypertension Receiving Selexipag in the SPHERE Registry by Race and Ethnicity Open
Introduction Racial/ethnic minority populations in the US have a high burden of pulmonary arterial hypertension (PAH). Objective To evaluate demographics, disease characteristics, prescribing patterns, hospitalization, and survival in raci…
View article: Ground-Glass Opacities in Pulmonary Arterial Hypertension—Results from the PVDOMICS Study
Ground-Glass Opacities in Pulmonary Arterial Hypertension—Results from the PVDOMICS Study Open
Rationale: Pulmonary hypertension (PH) is associated with significant morbidity and mortality. Ground-glass opacities (GGOs) are common in Group 1 PH, but their clinical significance is unclear. Objectives: We sought to characterize the cl…
View article: The landscape of referrals for lung transplantation in pulmonary arterial hypertension: A report from the Pulmonary Hypertension Association Registry
The landscape of referrals for lung transplantation in pulmonary arterial hypertension: A report from the Pulmonary Hypertension Association Registry Open
Rates of referral for lung transplantation in patients with PAH remain unacceptably low and occur too late. Increased awareness of the benefit of early referral is necessary, even at expert centers.
View article: Incidence of Right Ventricular Dysfunction in an Echocardiographic Referral Cohort
Incidence of Right Ventricular Dysfunction in an Echocardiographic Referral Cohort Open
Background Incidence rates of right ventricular dysfunction (RVD) are unknown. We examined the rates, risk factors, and heart failure (HF) hospitalization hazard associated with incident RVD and right ventricle‐pulmonary artery (RV‐PA) unc…
View article: Metabolomic Evidence of Biological Overlap with Heart Failure with Preserved Ejection Fraction in a Subset of Pulmonary Arterial Hypertension
Metabolomic Evidence of Biological Overlap with Heart Failure with Preserved Ejection Fraction in a Subset of Pulmonary Arterial Hypertension Open
Rationale A subset of patients with group 1 pulmonary hypertension (PH) have superimposed left heart abnormalities with unclear metabolic implications. Objectives To compare serum/transpulmonary metabolome between group 1 PH stratified by …
View article: Dysregulated Tricarboxylic Acid Cycle Metabolism Is Associated With Right Ventricular Maladaptation in Pulmonary Vascular Disease
Dysregulated Tricarboxylic Acid Cycle Metabolism Is Associated With Right Ventricular Maladaptation in Pulmonary Vascular Disease Open
Background Right ventricular (RV) maladaptation to elevated pulmonary afterload is the primary determinant of outcomes in pulmonary artery (PA) hypertension; however, the pathobiological mechanisms underlying RV decompensation remain poorl…
View article: Mas1 Receptor Activation is Necessary and Sufficient to Transduce ACE2 Effect in PAH, But Ang(1‐7) Alone is Insufficient
Mas1 Receptor Activation is Necessary and Sufficient to Transduce ACE2 Effect in PAH, But Ang(1‐7) Alone is Insufficient Open
ACE2 has shown effectiveness in treating pulmonary hypertension in multiple animal models and has some promise in early human trials. The key barrier to translation is that enzymatically active ACE2 is difficult to manufacture and exhibits…
View article: Physical Activity, Sleep, and Quality of Life in Pulmonary Arterial Hypertension: Novel Insights From Wearable Devices
Physical Activity, Sleep, and Quality of Life in Pulmonary Arterial Hypertension: Novel Insights From Wearable Devices Open
Reduced functional capacity and poor sleep quality are common in pulmonary arterial hypertension (PAH). Wearable devices are an emerging, user‐friendly tool to capture activity and sleep information. We aimed to determine whether Fitbit‐de…
View article: Characteristics of Daily Walking Bouts as Valid and Reliable Indicators of Exercise Capacity in Pulmonary Arterial Hypertension: Insights From the Randomized Controlled Study With Selexipag (TRACE)
Characteristics of Daily Walking Bouts as Valid and Reliable Indicators of Exercise Capacity in Pulmonary Arterial Hypertension: Insights From the Randomized Controlled Study With Selexipag (TRACE) Open
There is a need for objective, continuous and remote assessment of exercise capacity in patients with pulmonary arterial hypertension (PAH). Using data from the TRACE study, in which 108 adult patients with PAH were continuously monitored …
View article: Transcriptional Signatures of the Right Ventricle in End‐Stage Heart Failure
Transcriptional Signatures of the Right Ventricle in End‐Stage Heart Failure Open
The molecular mechanisms driving right ventricular (RV) adaptation to stress and failure in end‐stage heart failure (HF) are largely unknown. We aimed to characterize myocardial transcriptional changes in the RV caused by left sided HF and…
View article: Alterations in ECG and Right Heart Catheterization Data in PAH Patients Who Died From Sudden Death Compared With Right Heart Failure
Alterations in ECG and Right Heart Catheterization Data in PAH Patients Who Died From Sudden Death Compared With Right Heart Failure Open
A meaningful number of patients with PAH die suddenly, and there is little data to understand the events surrounding sudden death in PAH. We tested the hypothesis that sudden death is associated with pre‐mortem ECG or hemodynamics changes …
View article: Estrogen and Cyp1b1 Regulate Pparγ in Pulmonary Hypertension Through a Ubiquitin‐Dependent Mechanism
Estrogen and Cyp1b1 Regulate Pparγ in Pulmonary Hypertension Through a Ubiquitin‐Dependent Mechanism Open
Female sex increases risk of Group I pulmonary arterial hypertension by roughly threefold, but the mechanism is unclear. Low expression of Cyp1b1, an enzyme that metabolizes estrogens, is associated with disease penetrance, particularly in…
View article: How a Most Unlikely Drug Changed the Outcome of Pulmonary Arterial Hypertension
How a Most Unlikely Drug Changed the Outcome of Pulmonary Arterial Hypertension Open
Epoprostenol is a prostaglandin that was first identified by investigators in 1976 and found to be a potent vasodilator and inhibiter of platelet aggregation, initially in animal studies and subsequently in humans. Based on these propertie…
View article: Precision Medicine for Pulmonary Vascular Disease: The Future Is Now (2023 Grover Conference Series)
Precision Medicine for Pulmonary Vascular Disease: The Future Is Now (2023 Grover Conference Series) Open
Pulmonary vascular disease is not a single condition; rather it can accompany a variety of pathologies that impact the pulmonary vasculature. Applying precision medicine strategies to better phenotype, diagnose, monitor, and treat pulmonar…
View article: Alterations in Mitochondrial Function in Pulmonary Vascular Diseases
Alterations in Mitochondrial Function in Pulmonary Vascular Diseases Open
Aims: Alterations of mitochondrial bioenergetics and arginine metabolism are universally present and mechanistically linked to pulmonary arterial hypertension (PAH), but there is little knowledge of arginine metabolism and mitochondrial fu…
View article: Transcriptional Signatures of the Right Ventricle in End-Stage Heart Failure
Transcriptional Signatures of the Right Ventricle in End-Stage Heart Failure Open
Summary The molecular mechanisms of right ventricular (RV) adaptation to stress and failure in end stage heart failure (HF) are largely unknown. In this study, we performed transcriptomic analysis on paired RV and left ventricular (LV) myo…