Aaron S. Field
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View article: Tau mediates the impact of amyloid and vascular disease burden on the trajectory of clinical symptoms
Tau mediates the impact of amyloid and vascular disease burden on the trajectory of clinical symptoms Open
INTRODUCTION Amyloid (A) and vascular (V) pathologies often co‐occur and progress over decades. We leveraged chronicity, defined as the years above a biomarker‐positivity threshold, to examine how the timing of A and V relates to cognitive…
View article: Applied topographic component analysis for spatiotemporal decomposition of multichannel evoked potentials.
Applied topographic component analysis for spatiotemporal decomposition of multichannel evoked potentials. Open
Applied topographic component analysis for spatiotemporal decomposition of multichannel evoked potentials.
View article: Onset ages of cerebrovascular disease and amyloid and effects on cognition in risk-enriched cohorts
Onset ages of cerebrovascular disease and amyloid and effects on cognition in risk-enriched cohorts Open
The temporal relationship between cerebrovascular disease (V), indicated by white matter hyperintensities, and beta-amyloid (A) in Alzheimer’s disease remains unclear, prompting speculation about their potential interdependence. Longitudin…
View article: White matter hyperintensity onset, trajectories, and associations with cognitive decline in the presence of amyloid and tau
White matter hyperintensity onset, trajectories, and associations with cognitive decline in the presence of amyloid and tau Open
Background Cognitive decline is often influenced by Alzheimer’s disease (AD) pathology (e.g., beta‐amyloid burden) and other pathology (e.g., vascular abnormalities). Amyloid onset and chronicity estimation using Sampled Iterative Local Ap…
View article: White matter hyperintensity onset, trajectories, and associations with cognitive decline in the presence of amyloid and tau
White matter hyperintensity onset, trajectories, and associations with cognitive decline in the presence of amyloid and tau Open
Background Cognitive decline is often influenced by Alzheimer’s disease (AD) pathology (e.g., beta‐amyloid burden) and other pathology (e.g., vascular abnormalities). Amyloid onset and chronicity estimation using Sampled Iterative Local Ap…
View article: MRI and Clinical Variables for Prediction of Outcomes After Pediatric Severe Traumatic Brain Injury
MRI and Clinical Variables for Prediction of Outcomes After Pediatric Severe Traumatic Brain Injury Open
Importance Traumatic brain injury (TBI) is a leading cause of death and disability in children, and predicting functional outcome after TBI is challenging. Magnetic resonance imaging (MRI) is frequently conducted after severe TBI; however,…
View article: Unraveling diurnal and technical variability in cerebral hemodynamics from neurovascular 4D-Flow MRI
Unraveling diurnal and technical variability in cerebral hemodynamics from neurovascular 4D-Flow MRI Open
Neurovascular 4D-Flow MRI enables non-invasive evaluation of cerebral hemodynamics including measures of cerebral blood flow (CBF), vessel pulsatility index (PI), and cerebral pulse wave velocity (PWV). 4D-Flow measures have been linked to…
View article: Focused Abbreviated Survey MRI Protocols for Brain and Spine Imaging
Focused Abbreviated Survey MRI Protocols for Brain and Spine Imaging Open
There has been extensive growth in both the technical development and the clinical applications of MRI, establishing this modality as one of the most powerful diagnostic imaging tools. However, long examination and image interpretation tim…
View article: Incidental Findings from 16,400 Brain MRI Examinations of Research Volunteers
Incidental Findings from 16,400 Brain MRI Examinations of Research Volunteers Open
Four percent of individuals who undergo research brain MRIs have an incidental, potentially clinically significant finding. Routine neuroradiologist review of all scans yields a much higher rate of significant lesion detection than selecti…
View article: Harnessing cognitive trajectory clusterings to examine subclinical decline risk factors
Harnessing cognitive trajectory clusterings to examine subclinical decline risk factors Open
Cognitive decline in Alzheimer’s disease and other dementias typically begins long before clinical impairment. Identifying people experiencing subclinical decline may facilitate earlier intervention. This study developed cognitive trajecto…
View article: High‐resolution dynamic susceptibility contrast perfusion imaging using higher‐order temporal smoothness regularization
High‐resolution dynamic susceptibility contrast perfusion imaging using higher‐order temporal smoothness regularization Open
Purpose To improve image quality and resolution of dynamic susceptibility contrast perfusion weighted imaging (DSC‐PWI) by developing acquisition and reconstruction methods exploiting the temporal regularity property of DSC‐PWI signal. The…
View article: Magnetic Resonance Imaging Findings in Infants with Severe Traumatic Brain Injury and Associations with Abusive Head Trauma
Magnetic Resonance Imaging Findings in Infants with Severe Traumatic Brain Injury and Associations with Abusive Head Trauma Open
Young children with severe traumatic brain injury (TBI) have frequently been excluded from studies due to age and/or mechanism of injury. Magnetic resonance imaging (MRI) is now frequently being utilized to detect parenchymal injuries and …
View article: Peripartum cardiomyopathy: a global effort to find the cause and cure for the rare and little understood disease
Peripartum cardiomyopathy: a global effort to find the cause and cure for the rare and little understood disease Open
In this review, we present our current understanding of peripartum cardiomyopathy (PPCM) based on reports of the incidence, diagnosis and current treatment options. We summarise opinions on whether PPCM is triggered by vascular and/or horm…
View article: Simultaneous T<sub>1</sub>‐weighted and T<sub>2</sub>‐weighted 3D MRI using RF phase‐modulated gradient echo imaging
Simultaneous T<sub>1</sub>‐weighted and T<sub>2</sub>‐weighted 3D MRI using RF phase‐modulated gradient echo imaging Open
Purpose T 1 ‐weighted and T 2 ‐weighted (T1w and T2w) imaging are essential sequences in routine clinical practice to detect and characterize a wide variety of pathologies. Many approaches have been proposed to obtain T1w and T2w contrast,…
View article: Diffusion Tensor Imaging of Visual Pathway Abnormalities in Five Glaucoma Animal Models
Diffusion Tensor Imaging of Visual Pathway Abnormalities in Five Glaucoma Animal Models Open
Chronic IOP elevation was accompanied by decreased fractional anisotropy and increased radial diffusivity along the optic nerve or optic tract, suggestive of disrupted microstructural integrity in both inducible and genetic glaucoma animal…
View article: Feline irradiated diet-induced demyelination; a model of the neuropathology of sub-acute combined degeneration?
Feline irradiated diet-induced demyelination; a model of the neuropathology of sub-acute combined degeneration? Open
Irradiation of food at 50-55 kGy results in a profound, chronic demyelinating-remyelinating disease of the entire central nervous system (CNS) in cats, named Feline Irradiated Diet-Induced Demyelination (FIDID). This study examines the ear…
View article: Evoked potentials as a biomarker of remyelination
Evoked potentials as a biomarker of remyelination Open
Significance Remyelination is a critical therapeutic target in MS that will restore function and protect demyelinated axons. Clinical trials of putative remyelination-promoting drugs depend on valid, robust, and noninvasive outcome measure…
View article: Molecular Evolution of a Glioblastoma Controlled With Tumor Treating Fields and Concomitant Temozolomide
Molecular Evolution of a Glioblastoma Controlled With Tumor Treating Fields and Concomitant Temozolomide Open
Tumor Treating Field (TTFields) therapy has demonstrated efficacy in a Phase 3 study of newly diagnosed glioblastoma (GB) following radiation (RT) and temozolomide (TMZ). We report the appearance of an isolated satellite anterior temporal …
View article: Conventional and quantitative MRI in a novel feline model of demyelination and endogenous remyelination
Conventional and quantitative MRI in a novel feline model of demyelination and endogenous remyelination Open
Background The feeding of irradiated food to healthy adult cats results in widespread, noninflammatory demyelination of the central nervous system (CNS); a return to a normal diet results in endogenous remyelination with functional recover…
View article: Safety and efficacy of helminth treatment in relapsing-remitting multiple sclerosis: Results of the HINT 2 clinical trial
Safety and efficacy of helminth treatment in relapsing-remitting multiple sclerosis: Results of the HINT 2 clinical trial Open
Background: The hygiene hypothesis suggests that microbial replacement may be therapeutic in allergic and autoimmune diseases. Nevertheless, the results of helminth treatment, including in multiple sclerosis (MS), have been inconclusive. O…
View article: Synthetic MRI for Clinical Neuroimaging: Results of the Magnetic Resonance Image Compilation (MAGiC) Prospective, Multicenter, Multireader Trial
Synthetic MRI for Clinical Neuroimaging: Results of the Magnetic Resonance Image Compilation (MAGiC) Prospective, Multicenter, Multireader Trial Open
Overall synthetic MR imaging quality was similar to that of conventional proton-density, STIR, and T1- and T2-weighted contrast views across neurologic conditions. While artifacts were more common in synthetic T2 FLAIR, these were readily …
View article: The Impact of Intracranial Tumor Proximity to White Matter Tracts on Morbidity and Mortality: A Retrospective Diffusion Tensor Imaging Study
The Impact of Intracranial Tumor Proximity to White Matter Tracts on Morbidity and Mortality: A Retrospective Diffusion Tensor Imaging Study Open
BACKGROUND: Using diffusion tensor imaging (DTI) in neurosurgical planning allows identification of white matter tracts and has been associated with a reduction in postoperative functional deficits. OBJECTIVE: This study explores the relat…
View article: Four-dimensional flow magnetic resonance imaging and ultrasound assessment of cerebrospinal venous flow in multiple sclerosis patients and controls
Four-dimensional flow magnetic resonance imaging and ultrasound assessment of cerebrospinal venous flow in multiple sclerosis patients and controls Open
A possibly causal relationship between multiple sclerosis and chronic cerebrospinal venous insufficiency has recently been hypothesized. Studies investigating chronic cerebrospinal venous insufficiency have reported conflicting results and…