Anna Serefko
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View article: The Role of Probiotics and Their Postbiotic Metabolites in Post-COVID-19 Syndrome
The Role of Probiotics and Their Postbiotic Metabolites in Post-COVID-19 Syndrome Open
Post-COVID-19 syndrome, also known as long-COVID, is characterized by a wide spectrum of persistent symptoms involving multiple body organs and systems, including fatigue, gastrointestinal disorders, and neurocognitive dysfunction. Emergin…
View article: The Endocannabinoid System in the Development and Treatment of Obesity: Searching for New Ideas
The Endocannabinoid System in the Development and Treatment of Obesity: Searching for New Ideas Open
Obesity is a complex, multifactorial disease and a growing global health challenge associated with type 2 diabetes, cardiovascular disorders, cancer, and reduced quality of life. The existing pharmacological therapies are characterized by …
View article: Asiatic acid potentiates the activity of common antidepressant drugs in mice
Asiatic acid potentiates the activity of common antidepressant drugs in mice Open
Our findings give a new light on the potential use of asiatic acid in the management of depression. The terpenoid has antidepressant properties, potentially making it a valuable addition/adjunct to conventional treatment.
View article: Exploring the Toxicity and Therapeutic Potential of A. dahurica and A. pubescens in Zebrafish Larvae: Insights into Anxiety Treatment Mechanisms
Exploring the Toxicity and Therapeutic Potential of A. dahurica and A. pubescens in Zebrafish Larvae: Insights into Anxiety Treatment Mechanisms Open
This study assessed the toxicity and therapeutic potential of Angelica dahurica and Angelica pubescens using Danio rerio (zebrafish) larvae. Toxicity was evaluated through mortality, malformations, and gene expression changes related to st…
View article: Zebrafish as a Suitable Model for Utilizing the Bioactivity of Coumarins and Coumarin-Based Compounds
Zebrafish as a Suitable Model for Utilizing the Bioactivity of Coumarins and Coumarin-Based Compounds Open
The aim of this review is to summarize the current knowledge on the use of coumarin-derived compounds in the zebrafish (Danio rerio) model. Coumarins, a class of naturally occurring compounds with diverse biological activities, including c…
View article: The Novel Imipramine–Magnesium Complex Exerts Antidepressant-like Activity in Mice Subjected to the Forced Swim Test and the Tail Suspension Test
The Novel Imipramine–Magnesium Complex Exerts Antidepressant-like Activity in Mice Subjected to the Forced Swim Test and the Tail Suspension Test Open
The objective of this study was to assess the antidepressant efficacy of a novel imipramine–magnesium (IMI–Mg) complex in comparison to the administration of imipramine and magnesium individually. The study utilized adult male albino Swiss…
View article: The Orexin OX<sub>2</sub> Receptor‐Dependent Pathway Is Implicated in the Development of Overactive Bladder and Depression in Rats Exposed to Corticosterone
The Orexin OX<sub>2</sub> Receptor‐Dependent Pathway Is Implicated in the Development of Overactive Bladder and Depression in Rats Exposed to Corticosterone Open
Aim In the present study, we wanted to check whether TCS OX2 29 (TCS), a potent selective antagonist of OX2 receptors, would have positive effects in an animal model of detrusor overactivity co‐existed with the depression‐like state in Wis…
View article: Omega-3 Polyunsaturated Fatty Acids in Depression
Omega-3 Polyunsaturated Fatty Acids in Depression Open
Omega-3 polyunsaturated fatty acids have received considerable attention in the field of mental health, in particular regarding the treatment of depression. This review presents an overview of current research on the role of omega-3 fatty …
View article: Nutritional Quality Implications: Exploring the Impact of a Fatty Acid-Rich Diet on Central Nervous System Development
Nutritional Quality Implications: Exploring the Impact of a Fatty Acid-Rich Diet on Central Nervous System Development Open
Given the comprehensive examination of the role of fatty acid-rich diets in central nervous system development in children, this study bridges significant gaps in the understanding of dietary effects on neurodevelopment. It delves into the…
View article: Evaluation of Antidepressive-like Behaviours and Oxidative Stress Parameters in Mice Receiving Imipramine-Zinc Complex Compound
Evaluation of Antidepressive-like Behaviours and Oxidative Stress Parameters in Mice Receiving Imipramine-Zinc Complex Compound Open
The study aimed to evaluate the antidepressant-like effects of an imipramine-zinc (IMI-Zn) complex compound on mice and assess the level of oxidative stress parameters. The research also investigated whether the IMI-Zn complex showed super…
View article: Zebrafish as an Animal Model in Cannabinoid Research
Zebrafish as an Animal Model in Cannabinoid Research Open
Cannabinoids are active substances present in plants of the Cannabis genus. Both the Food and Drug Administration (FDA) and European Medicines Agency (EMA) have approved several medicinal products containing natural cannabinoids or their s…
View article: The role of the L-arginine-NO-cGMP pathway in the development of tolerance to mephedrone-induced hyperlocomotion in mice
The role of the L-arginine-NO-cGMP pathway in the development of tolerance to mephedrone-induced hyperlocomotion in mice Open
The tendency of a psychostimulant to increase locomotion in rodents is considered to be associated with its addictive properties. Mephedrone, one of the most popular psychoactive substances used recreationally, is known to enhance locomoto…
View article: The <scp>L‐arginine‐NO‐cGMP</scp> pathway mediates the locomotor activity alterations during the expression of sensitization to mephedrone in mice
The <span>L‐arginine‐NO‐cGMP</span> pathway mediates the locomotor activity alterations during the expression of sensitization to mephedrone in mice Open
Mephedrone is a representative of synthetic cathinones that is known from its rewarding and psychostimulant effects. It exerts behavioural sensitization after repeated and then interrupted administration. In our study, we investigated a ro…
View article: The Role of Probiotics and Their Metabolites in the Treatment of Depression
The Role of Probiotics and Their Metabolites in the Treatment of Depression Open
Depression is a common and complex mental and emotional disorder that causes disability, morbidity, and quite often mortality around the world. Depression is closely related to several physical and metabolic conditions causing metabolic de…
View article: The Cannabinoid Ligand Arachidonyl-2′-Chloroethylamide (ACEA) Ameliorates Depressive and Overactive Bladder Symptoms in a Corticosterone-Induced Female Wistar Rat Model
The Cannabinoid Ligand Arachidonyl-2′-Chloroethylamide (ACEA) Ameliorates Depressive and Overactive Bladder Symptoms in a Corticosterone-Induced Female Wistar Rat Model Open
There is growing need to increase the knowledge on the cannabinoid ligands in the treatment of overactive bladder. Among potential candidates, arachidonyl-2′-chloroethylamide (ACEA), a selective cannabinoid CB1 receptor agonist is proposed…
View article: Attitudes and behaviors regarding online pharmacies in the aftermath of COVID-19 pandemic: At the tipping point towards the new normal
Attitudes and behaviors regarding online pharmacies in the aftermath of COVID-19 pandemic: At the tipping point towards the new normal Open
The COVID-19 pandemic accelerated the online purchase of goods and services in which today’s e-pharmacy is now an integral part of healthcare provisions in developed countries. The aim of our research was to assess the frequency and attitu…
View article: Effects of Selen on the Antidepressant-like Activity of Agents Affecting the Adenosinergic Neurotransmission
Effects of Selen on the Antidepressant-like Activity of Agents Affecting the Adenosinergic Neurotransmission Open
The main goal of this study was to determine the antidepressant-like potential of the co-administration of sodium selenite (Se) and the selective adenosine A1 and A2A antagonists DPCPX and istradefylline (IST), respectively, in mice despai…
View article: Alterations of Serum Magnesium Concentration in Animal Models of Seizures and Epilepsy—The Effects of Treatment with a GPR39 Agonist and Knockout of the Gpr39 Gene
Alterations of Serum Magnesium Concentration in Animal Models of Seizures and Epilepsy—The Effects of Treatment with a GPR39 Agonist and Knockout of the Gpr39 Gene Open
Several ligands have been proposed for the GPR39 receptor, including the element zinc. The relationship between GPR39 and magnesium homeostasis has not yet been examined, nor has such a relationship in the context of seizures/epilepsy. We …
View article: Central Effects of the Designer Drug Mephedrone in Mice—Basic Studies
Central Effects of the Designer Drug Mephedrone in Mice—Basic Studies Open
Mephedrone belongs to the “party drugs” thanks to its psychostimulant effects, similar to the ones observed after amphetamines. Though mephedrone is used worldwide by humans and in laboratory animals, not all properties of this drug have b…
View article: Yeast Protein as an Easily Accessible Food Source
Yeast Protein as an Easily Accessible Food Source Open
In recent years, the awareness and willingness of consumers to consume healthy food has grown significantly. In order to meet these needs, scientists are looking for innovative methods of food production, which is a source of easily digest…
View article: Influence of Smallanthus sonchifolius (Yacon) on the Activity of Antidepressant Drugs in Mice
Influence of Smallanthus sonchifolius (Yacon) on the Activity of Antidepressant Drugs in Mice Open
Depression is one of the most common mental disorders in the world that negatively affects the daily functioning of patients. Numerous studies are currently being conducted to examine the antidepressant potential of innovative synthetic co…
View article: The role of microbiota-gut-brain axis in neuropsychiatric and neurological disorders
The role of microbiota-gut-brain axis in neuropsychiatric and neurological disorders Open
Emerging evidence indicates that the gut microbiota play a crucial role in the bidirectional communication between the gut and the brain suggesting that the gut microbes may shape neural development, modulate neurotransmission and affect b…
View article: Zebrafish as an Animal Model for Testing Agents with Antidepressant Potential
Zebrafish as an Animal Model for Testing Agents with Antidepressant Potential Open
Depression is a serious mental disease that, according to statistics, affects 320 million people worldwide. Additionally, a current situation related to the COVID-19 pandemic has led to a significant deterioration of mental health in peopl…
View article: Effects of new antiseizure drugs on seizure activity and anxiety-like behavior in adult zebrafish
Effects of new antiseizure drugs on seizure activity and anxiety-like behavior in adult zebrafish Open
Several studies with larvae and adult zebrafish have shown that old and new antiseizure drugs (ASDs) produce discrepant results in seizure tests, locomotor activity or anxiety models. In this study, the pentylenetetrazole seizure test (PTZ…
View article: The Interaction of Selective A1 and A2A Adenosine Receptor Antagonists with Magnesium and Zinc Ions in Mice: Behavioural, Biochemical and Molecular Studies
The Interaction of Selective A1 and A2A Adenosine Receptor Antagonists with Magnesium and Zinc Ions in Mice: Behavioural, Biochemical and Molecular Studies Open
The purpose of the study was to investigate whether the co-administration of Mg2+ and Zn2+ with selective A1 and A2A receptor antagonists might be an interesting antidepressant strategy. Forced swim, tail suspension, and spontaneous locomo…
View article: Asiatic Acid, a Natural Compound that Exerts Beneficial Effects on the Cystometric and Biochemical Parameters in the Retinyl Acetate-Induced Model of Detrusor Overactivity
Asiatic Acid, a Natural Compound that Exerts Beneficial Effects on the Cystometric and Biochemical Parameters in the Retinyl Acetate-Induced Model of Detrusor Overactivity Open
Scientists have been constantly looking for new synthetic and natural compounds that could have beneficial effects in bladder overactivity. Our attention was drawn by asiatic acid that influences a number of molecules and signaling pathway…
View article: POTENTIAL DRUG-DRUG INTERACTIONS IDENTIFIED AS DRUG-RELATED PROBLEMS IN THE TREATMENT OF HOSPITALIZED PATIENTS WITH GASTRITIS AND/OR DUODENITIS OR PEPTIC ULCER DISEASE IN LUBLIN (POLAND) – AN OBSERVATIONAL STUDY
POTENTIAL DRUG-DRUG INTERACTIONS IDENTIFIED AS DRUG-RELATED PROBLEMS IN THE TREATMENT OF HOSPITALIZED PATIENTS WITH GASTRITIS AND/OR DUODENITIS OR PEPTIC ULCER DISEASE IN LUBLIN (POLAND) – AN OBSERVATIONAL STUDY Open
Gastritis, duodenitis and peptic ulcer disease (PUD) belong to the most common health problems of the gastrointestinal system.Gastritis is an inflammatory process of the gastric mucosa, whereas duodenitis is an inflammation of the duodenal…