Anna Simonelli
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View article: Effect of Periodontal Treatment on Metabolic Syndrome Parameters: A Systematic Review
Effect of Periodontal Treatment on Metabolic Syndrome Parameters: A Systematic Review Open
Aim To evaluate the effects of periodontal treatment on metabolic syndrome (MS) parameters and systemic inflammatory biomarker levels in patients affected by both MS and periodontitis. Methods A systematic search was conducted to identify …
View article: Factors influencing pocket closure in surgically-treated intraosseous defects. A retrospective analysis
Factors influencing pocket closure in surgically-treated intraosseous defects. A retrospective analysis Open
Objectives to evaluate the association between patient- and local- factors and pocket closure (i.e., probing depth, PD, ≤4 mm) following surgical treatment of intraosseous defects with the Single Flap Approach (SFA). Materials & methods a …
View article: Emerging Applications of Digital Technologies for Periodontal Screening, Diagnosis and Prognosis in the Dental Setting
Emerging Applications of Digital Technologies for Periodontal Screening, Diagnosis and Prognosis in the Dental Setting Open
Aim To comprehensively review digital technologies (including artificial intelligence, AI) for periodontal screening, diagnosis and prognosis in the dental setting, focusing on accuracy metrics. Materials and Methods Two separate literatur…
View article: Sexual dimorphism in periodontal inflammation: A cross‐sectional study
Sexual dimorphism in periodontal inflammation: A cross‐sectional study Open
Background The purpose of the present study was to evaluate the role of sexual dimorphism (SD) in the clinical manifestation of plaque‐induced periodontal inflammation by analyzing the association between patient‐related factors and the fu…
View article: Correction of Peri‐Implant Buccal Bone Dehiscence Following Sub‐Periosteal Peri‐Implant Augmented Layer Technique With Either Block or Particulate Xenograft: A Retrospective Study
Correction of Peri‐Implant Buccal Bone Dehiscence Following Sub‐Periosteal Peri‐Implant Augmented Layer Technique With Either Block or Particulate Xenograft: A Retrospective Study Open
Objective To evaluate the effectiveness of Sub‐periosteal Peri‐implant Augmented Layer (SPAL) technique performed with deproteinized bovine bone mineral (DBBM), delivered either as particulate (pDBBM) or block (bDBBM), in correcting a peri…
View article: Factors affecting radiographic marginal bone resorption at dental implants in function for at least 5 years: A multicenter retrospective study
Factors affecting radiographic marginal bone resorption at dental implants in function for at least 5 years: A multicenter retrospective study Open
Objective To evaluate the influence of patient and implant‐related factors on the changes of marginal bone levels (MBL) at implants with a follow‐up ≥5 years. Materials and Methods At baseline (within 6 months from prosthetic insertion) an…
View article: Efficacy of communicating periodontal risk on psychological outcomes and supragingival plaque control in patients undergoing first periodontal consultation: A parallel‐arm, randomized trial
Efficacy of communicating periodontal risk on psychological outcomes and supragingival plaque control in patients undergoing first periodontal consultation: A parallel‐arm, randomized trial Open
Aim To evaluate the efficacy of the PerioRisk prognostic tool in implementing the effect of motivational interviewing (MI) on psychological outcomes and supragingival plaque control. Materials and Methods Participants underwent MI immediat…
View article: Accuracy and applicability of periodontitis risk assessment tools: A critical appraisal
Accuracy and applicability of periodontitis risk assessment tools: A critical appraisal Open
Currently, periodontal risk assessment finds application at first visit (to identify individuals at high risk of either disease incidence, if still healthy, or disease progression, if already diseased) as well as at patient monitoring afte…
View article: Six‐year extension results of a randomized trial comparing transcrestal and lateral sinus floor elevation at sites with 3–6 mm of residual bone
Six‐year extension results of a randomized trial comparing transcrestal and lateral sinus floor elevation at sites with 3–6 mm of residual bone Open
Objectives To comparatively evaluate the 6‐year outcomes of transcrestal and lateral sinus floor elevation (tSFE and lSFE, respectively). Methods The 54 patients representing the per‐protocol population of a randomized trial comparing impl…
View article: Functional profile of oral plaque microbiome: Further insight into the bidirectional relationship between type 2 diabetes and periodontitis
Functional profile of oral plaque microbiome: Further insight into the bidirectional relationship between type 2 diabetes and periodontitis Open
Increasing evidence support the association between the oral microbiome and human systemic diseases. This association may be attributed to the ability of many oral microbes to influence the inflammatory microenvironment. Herein, we focused…
View article: Prognostic value of a composite outcome measure for periodontal stability following periodontal regenerative treatment: A retrospective analysis at 4 years
Prognostic value of a composite outcome measure for periodontal stability following periodontal regenerative treatment: A retrospective analysis at 4 years Open
Background Recently, a composite outcome measure (COM) was proposed to describe the short‐term results of periodontal regenerative treatment. The present retrospective study aimed at evaluating the prognostic value of COM on clinical attac…
View article: Supplementary Data S3 from Disabled Homolog 2 Controls Prometastatic Activity of Tumor-Associated Macrophages
Supplementary Data S3 from Disabled Homolog 2 Controls Prometastatic Activity of Tumor-Associated Macrophages Open
Description of the functional status of WT and Dab2 KO macrophages. Related to Fig. 1C-D
View article: Supplementary Data S1 from Disabled Homolog 2 Controls Prometastatic Activity of Tumor-Associated Macrophages
Supplementary Data S1 from Disabled Homolog 2 Controls Prometastatic Activity of Tumor-Associated Macrophages Open
Marker genes for each cell type identified in tumor-infiltrating myeloid cells.Related to Fig.1A
View article: Supplementary Data from Disabled Homolog 2 Controls Prometastatic Activity of Tumor-Associated Macrophages
Supplementary Data from Disabled Homolog 2 Controls Prometastatic Activity of Tumor-Associated Macrophages Open
Supplementary Figures, Tables, Methods
View article: Supplementary Data S1 from Disabled Homolog 2 Controls Prometastatic Activity of Tumor-Associated Macrophages
Supplementary Data S1 from Disabled Homolog 2 Controls Prometastatic Activity of Tumor-Associated Macrophages Open
Marker genes for each cell type identified in tumor-infiltrating myeloid cells.Related to Fig.1A
View article: Data from Disabled Homolog 2 Controls Prometastatic Activity of Tumor-Associated Macrophages
Data from Disabled Homolog 2 Controls Prometastatic Activity of Tumor-Associated Macrophages Open
Tumor-associated macrophages (TAM) are regulators of extracellular matrix (ECM) remodeling and metastatic progression, the main cause of cancer-associated death. We found that disabled homolog 2 mitogen-responsive phosphoprotein (DAB2) is …
View article: Supplementary Data S2 from Disabled Homolog 2 Controls Prometastatic Activity of Tumor-Associated Macrophages
Supplementary Data S2 from Disabled Homolog 2 Controls Prometastatic Activity of Tumor-Associated Macrophages Open
Marker genes for macrophages clusters from WT and Dab2 KO samples. Related to Fig. 1C-D
View article: Supplementary Data S3 from Disabled Homolog 2 Controls Prometastatic Activity of Tumor-Associated Macrophages
Supplementary Data S3 from Disabled Homolog 2 Controls Prometastatic Activity of Tumor-Associated Macrophages Open
Description of the functional status of WT and Dab2 KO macrophages. Related to Fig. 1C-D
View article: Data from Disabled Homolog 2 Controls Prometastatic Activity of Tumor-Associated Macrophages
Data from Disabled Homolog 2 Controls Prometastatic Activity of Tumor-Associated Macrophages Open
Tumor-associated macrophages (TAM) are regulators of extracellular matrix (ECM) remodeling and metastatic progression, the main cause of cancer-associated death. We found that disabled homolog 2 mitogen-responsive phosphoprotein (DAB2) is …
View article: Supplementary Data from Disabled Homolog 2 Controls Prometastatic Activity of Tumor-Associated Macrophages
Supplementary Data from Disabled Homolog 2 Controls Prometastatic Activity of Tumor-Associated Macrophages Open
Supplementary Figures, Tables, Methods
View article: Supplementary Data S2 from Disabled Homolog 2 Controls Prometastatic Activity of Tumor-Associated Macrophages
Supplementary Data S2 from Disabled Homolog 2 Controls Prometastatic Activity of Tumor-Associated Macrophages Open
Marker genes for macrophages clusters from WT and Dab2 KO samples. Related to Fig. 1C-D
View article: Minimal invasiveness in the surgical treatment of intraosseous defects: A systematic review
Minimal invasiveness in the surgical treatment of intraosseous defects: A systematic review Open
The modern approach to regenerative treatment of periodontal intraosseous defects should aim at maximizing the clinical outcomes while minimizing the invasiveness (pain, complications, aesthetic impairment, chair time, and costs) of the pr…
View article: Minimal invasiveness in the transcrestal elevation of the maxillary sinus floor: A systematic review
Minimal invasiveness in the transcrestal elevation of the maxillary sinus floor: A systematic review Open
In the attempt to reduce the invasiveness of a transcrestal sinus floor elevation procedure, different aspects must be considered; that is, the minimization of intra‑ and postsurgery morbidity, the reduction of treatment time, and the simp…
View article: Effect of lateral bone augmentation procedures in correcting peri‐implant bone dehiscence and fenestration defects: A systematic review and network meta‐analysis
Effect of lateral bone augmentation procedures in correcting peri‐implant bone dehiscence and fenestration defects: A systematic review and network meta‐analysis Open
Purpose The aim of the present systematic review was to evaluate the effect of different lateral bone augmentation (LBA) procedures on the complete correction of a peri‐implant bone dehiscence (BD) or fenestration (BF) from implant placeme…
View article: No benefit of an adjunctive phototherapy protocol in treatment of periodontitis: A split‐mouth randomized controlled trial
No benefit of an adjunctive phototherapy protocol in treatment of periodontitis: A split‐mouth randomized controlled trial Open
Aim To assess the efficacy of a commercially available adjunctive phototherapy protocol (“Perio‐1”) in treatment of periodontitis. Materials and Methods In an examiner‐blind, randomized, controlled, split‐mouth, multicentre study, 60 perio…
View article: Peri‐implant tissue conditions at implants treated with Sub‐periosteal Peri‐implant Augmented Layer technique: A retrospective case series
Peri‐implant tissue conditions at implants treated with Sub‐periosteal Peri‐implant Augmented Layer technique: A retrospective case series Open
Objectives To assess peri‐implant tissue conditions on the short term in patients receiving the Sub‐periosteal Peri‐implant Augmented Layer (SPAL) technique and in patients with adequate thickness (≥2 mm) of the peri‐implant buccal bone pl…
View article: Disabled Homolog 2 Controls Prometastatic Activity of Tumor-Associated Macrophages
Disabled Homolog 2 Controls Prometastatic Activity of Tumor-Associated Macrophages Open
Tumor-associated macrophages (TAM) are regulators of extracellular matrix (ECM) remodeling and metastatic progression, the main cause of cancer-associated death. We found that disabled homolog 2 mitogen-responsive phosphoprotein (DAB2) is …
View article: Sub‐Periosteal Peri‐Implant Augmented Layer Technique to Treat Peri‐Implantitis Lesions
Sub‐Periosteal Peri‐Implant Augmented Layer Technique to Treat Peri‐Implantitis Lesions Open
Introduction The efficacy of surgical regenerative procedures to treat peri‐implantitis lesions has been extensively reviewed. Regenerative treatment showed a variable rate of success, in terms of pocket reduction, gain in bone support, an…