Anna J Smart
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View article: Analysis of categorical data from biological experiments with logistic regression and CMH tests
Analysis of categorical data from biological experiments with logistic regression and CMH tests Open
The choice of appropriate statistical tests in experimental biology is critical for scientific rigor and can be challenging in the case of categorical data analysis. Using example datasets from Caenorhabditis elegans research, we conduct s…
View article: Analysis of categorical data from biological experiments with logistic regression and CMH tests
Analysis of categorical data from biological experiments with logistic regression and CMH tests Open
The choice of appropriate statistical tests in experimental biology is critical for scientific rigor and can be challenging in the case of categorical data analysis. Using example datasets from Caenorhabditis elegans research, we conduct s…
View article: Analysis of Categorical Data with Logistic Regression and the Cochran–Mantel–Haenszel Tests in Biological Experiments
Analysis of Categorical Data with Logistic Regression and the Cochran–Mantel–Haenszel Tests in Biological Experiments Open
The choice of statistical test is a fundamentally important one when analyzing experimental data. Here, we consider the question of categorical data, defined by their properties (for example color) rather than by continuous numbering. Usin…
View article: Mechanical force of uterine occupation enables large vesicle extrusion from proteostressed maternal neurons
Mechanical force of uterine occupation enables large vesicle extrusion from proteostressed maternal neurons Open
Large vesicle extrusion from neurons may contribute to spreading pathogenic protein aggregates and promoting inflammatory responses, two mechanisms leading to neurodegenerative disease. Factors that regulate the extrusion of large vesicles…
View article: Mechanical force of uterine occupation enables large vesicle extrusion from proteostressed maternal neurons
Mechanical force of uterine occupation enables large vesicle extrusion from proteostressed maternal neurons Open
Large vesicle extrusion from neurons may contribute to spreading pathogenic protein aggregates and promoting inflammatory responses, two mechanisms leading to neurodegenerative disease. Factors that regulate extrusion of large vesicles, su…
View article: Author response: Mechanical force of uterine occupation enables large vesicle extrusion from proteostressed maternal neurons
Author response: Mechanical force of uterine occupation enables large vesicle extrusion from proteostressed maternal neurons Open
Large vesicle extrusion from neurons may contribute to spreading pathogenic protein aggregates and promoting inflammatory responses, two mechanisms leading to neurodegenerative disease. Factors that regulate extrusion of large vesicles, su…
View article: Mechanical force of uterine occupation enables large vesicle extrusion from proteostressed maternal neurons
Mechanical force of uterine occupation enables large vesicle extrusion from proteostressed maternal neurons Open
Large vesicle extrusion from neurons may contribute to spreading pathogenic protein aggregates and promoting inflammatory responses, two mechanisms leading to neurodegenerative disease. Factors that regulate extrusion of large vesicles, su…
View article: Mechanical force of uterine occupation enables large vesicle extrusion from proteostressed maternal neurons
Mechanical force of uterine occupation enables large vesicle extrusion from proteostressed maternal neurons Open
Large vesicle extrusion from neurons may contribute to spreading pathogenic protein aggregates and promoting inflammatory responses, two mechanisms leading to neurodegenerative disease. Factors that regulate the extrusion of large vesicles…
View article: Reviewer #1 (Public Review): Mechanical force of uterine occupation enables large vesicle extrusion from proteostressed maternal neurons
Reviewer #1 (Public Review): Mechanical force of uterine occupation enables large vesicle extrusion from proteostressed maternal neurons Open
Large vesicle extrusion from neurons may contribute to spreading pathogenic protein aggregates and promoting inflammatory responses, two mechanisms leading to neurodegenerative disease. Factors that regulate extrusion of large vesicles, su…
View article: Reviewer #3 (Public Review): Mechanical force of uterine occupation enables large vesicle extrusion from proteostressed maternal neurons
Reviewer #3 (Public Review): Mechanical force of uterine occupation enables large vesicle extrusion from proteostressed maternal neurons Open
Large vesicle extrusion from neurons may contribute to spreading pathogenic protein aggregates and promoting inflammatory responses, two mechanisms leading to neurodegenerative disease. Factors that regulate extrusion of large vesicles, su…
View article: Mechanical force of uterine occupation enables large vesicle extrusion from proteostressed maternal neurons
Mechanical force of uterine occupation enables large vesicle extrusion from proteostressed maternal neurons Open
Large vesicle extrusion from neurons may contribute to spreading pathogenic protein aggregates and promoting inflammatory responses, two mechanisms leading to neurodegenerative disease. Factors that regulate extrusion of large vesicles, su…
View article: Large vesicle extrusions from C. elegans neurons are consumed and stimulated by glial-like phagocytosis activity of the neighboring cell
Large vesicle extrusions from C. elegans neurons are consumed and stimulated by glial-like phagocytosis activity of the neighboring cell Open
Caenorhabditis elegans neurons under stress can produce giant vesicles, several microns in diameter, called exophers. Current models suggest that exophers are neuroprotective, providing a mechanism for stressed neurons to eject toxic prote…
View article: Intermediate Filaments Associate with Aggresome-like Structures in Proteostressed<i>C. elegans</i>Neurons and Influence Large Vesicle Extrusions as Exophers
Intermediate Filaments Associate with Aggresome-like Structures in Proteostressed<i>C. elegans</i>Neurons and Influence Large Vesicle Extrusions as Exophers Open
Under conditions of proteostasis disequilibrium, neurons can enhance intracellular and extracellular protective mechanisms to guard against neurotoxicity. In mammals, an intracellular response to severe proteostasis imbalance that results …