Anna G. Smirnova
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Diffusion of macromolecules in extracellular matrix mimetic hydrogels – effect of size and charge Open
Subcutaneous (SC) injection is the primary alternative to oral administration for therapeutic proteins and peptides. However, bioavailability and absorption rate are often variable and difficult to predict. Therefore, there is a need for n…
Unpacking Maximum Extractable Value on Polygon: A Study on Atomic Arbitrage Open
The evolution of blockchain technology, from its origins as a decentralized ledger for cryptocurrencies to its broader applications in areas like decentralized finance (DeFi), has significantly transformed financial ecosystems while introd…
View article: Wave 2 of the Multilingual Eye-Movement Corpus (MECO): New text reading data across languages
Wave 2 of the Multilingual Eye-Movement Corpus (MECO): New text reading data across languages Open
This paper reports the Wave 2 expansion of the Multilingual Eye-Movement Corpus (MECO), a collaborative multi-lab project collecting eye-tracking data on text reading in a variety of languages. The present expansion comes with new eye-trac…
How to reduce the risk of primary engraftment failure after haploidentical hematopoietic stem cell transplantation in patients with acute myeloid leukemia? Open
Background. Haploidentical hematopoietic stem cell transplantation (haplo‑HSCT) represents an important alternative for patients with acute myeloid leukemia (AML) who lack an HLA‑matched donor. However, the high incidence of primary graft …
Targeted therapy of newly diagnosed FLT3-mutated acute myeloid leukemia. A single-center ambispective cohort study Open
Background. FMS‑like tyrosine kinase 3 (FLT3) gene mutations are the most frequently detected genetic aberrations in adult patients with newly diagnosed acute myeloid leukemia (AML), identified in approximately 30 % of patients. The additi…
View article: New data on text reading in English as a second language
New data on text reading in English as a second language Open
This paper reports an expansion of the English as a second language (L2) component of the Multilingual Eye Movement Corpus (MECO L2), an international database of eye movements during text reading. While the previous Wave 1 of the MECO pro…
The effect of the global language context on bilingual language control during L1 reading Open
The proactive gain control hypothesis suggests that the global language context regulates lexical access to the bilinguals’ languages during reading. Specifically, with increasing exposure to non-target language cues, bilinguals adjust the…
Daratumumab in post-transplantation pure red cell aplasia in adults Open
Post-transplant pure red cell aplasia (PRCA) is a rare complication that occurs after allogeneic hematopoietic stem cell transplantation (allo-HSCT) with ABO incompatibility.In most cases, this condition resolves without any treatment.Howe…
T-cell prolymphocytic leukemia (T-PLL): a clinical case and review of the literature Open
T-cell prolymphocytic leukemia (T-PLL) is a rare aggressive lymphoid malignancy, with a poor response to chemotherapy and unfavorable prognosis.The presented clinical case demonstrates the effectiveness of allogeneic hematopoietic stem cel…
A pilot study of implication of machine learning for relapse prediction after allogeneic stem cell transplantation in adults with Ph-positive acute lymphoblastic leukemia Open
The posttransplant relapse in Ph-positive ALL increases the risk of death. There is an unmet need for instruments to predict the risk of relapse and plan prophylaxis. In this study, we analyzed posttransplant data by machine learning algor…
View article: The Role of Autologous Hematopoietic Stem Cell Transplantation in the Therapy of Systemic AL Amyloidosis
The Role of Autologous Hematopoietic Stem Cell Transplantation in the Therapy of Systemic AL Amyloidosis Open
Aim. To assess the outcomes of autologous hematopoietic stem cell transplantation (auto-HSCT) in systemic AL Amyloidosis patients treated at the R.M. Gorbacheva Scientific Research Institute of Pediatric Oncology, Hematology and Transplant…
View article: Trends in Outcome of Hematopoietic Stem Cell Transplantation: 5000 Transplantations and 30 Years of Single-Center Experience
Trends in Outcome of Hematopoietic Stem Cell Transplantation: 5000 Transplantations and 30 Years of Single-Center Experience Open
In this single-center analysis, we evaluated the trends in 5185 hematopoietic cell transplantations performed between 1990 and 2022. The study group comprised 3237 allogeneic (alloHCT) and 1948 autologous (autoHCT) hematopoietic cell trans…
Place of Allogeneic Hematopoietic Stem Cell Transplantation in the First Complete Remission in Ph-positive Acute Lymphoblastic Leukemia in Adults Open
Introduction. Ph-positive acute lymphoblastic leukemia (ALL) is a high risk group of B-lineage acute lymphoblastic leukemia (B-ALL). Since tyrosine kinase inhibitors (TKIs) were introduced, controversial data have been obtained on the effi…
PB1853: OUTCOMES REFRACTORY/RELAPSED ACUTE MYELOID LEUKEMIA WITH EXTRAMEDULLARY MANIFESTATIONS AFTER GEMTUZUMAB OZOGAMICIN THERAPY Open
Topic: 4. Acute myeloid leukemia - Clinical Background: Extramedullary manifestations (EM) are rare event in acute myeloid leukemia (AML) and occur in 3 to 10% at the time of diagnosis. However, the rate of EM can be up to 30% at relapse a…
Toxic and infectious lung injury differential diagnosis specifics in oncohematological patients Open
Background. Assessment of lung injury in oncohematological patients is a relevant problem, since the spectrum of pathological changes is wide and includes pulmonary infections, tumor cell infiltration, cardiogenic and non-cardiogenic pulmo…
Implication of machine learning for relapse prediction after allogeneic stem cell transplantation in adults with Ph-positive acute lymphoblastic leukemia Open
The posttransplant relapse in Ph-positive ALL increases the risk of death. There is an unmet need for instruments to predict the risk of relapse and plan prophylaxis treatments. In this study we analyzed posttransplant data by machine lear…
Available drugs during of military state: social-economic strategies of functioning reimbursumen’t system Open
The Russian aggresion against Ukraine became a new reality in the XXI century and definitely shook the whole World. New realities are forcing all spheres of science and practice to work harder and develop, that is why philosophers of law a…
Tyrosine kinase inhibitors: relapse prophylaxis after allogeneic hematopoietic stem cell transplantation in adults with Philadelphia chromosome-positive acute lymphoblastic leukemia Open
The role of prophylactic TKIs after allogeneic stem cell transplantation in Ph-positive acute lymphoblastic leukemia (ALL) remains controversial.We performed a retrospective study in 106 adult patients subjected to allogeneic hematopoietic…
Efficacy and Safety of Midostaurin Combined with Chemotherapy in Newly Diagnosed Acute Myeloid Leukemia with FLT3 Mutation Open
Background. The detection of FLT3-ITD mutation in acute myeloid leukemia (AML) patients is associated with poor prognosis and is an indication for allogeneic hematopoietic stem cell transplantation (allo-HSCT) in the first remission. Midos…
Incidence, risk factors and clinical characteristics of bronchiolitis obliterans after allogeneic hematopoietic stem cell transplantation Open
Bronchiolitis obliterans (BO) is a severe form of chronic graft-versus-host disease (cGVHD) after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Aim. The aim of current study was to evaluate the incidence, risk factors, an…
Comparison of bortesomib-based induction regimens with other treatment modalities in patients with newly diagnosed systemic light chain amyloidosis ineligible for autologous stem cell transplantation Open
Systemic light chain (AL) amyloidosis is a form of plasma cell disorders, characterized by overproduction of immunoglobulin light chains by clonal plasma cells and their deposition in organs and tissues as an insoluble fibrillar protein-am…
Journey of a hematopoietic stem cell transplantation center through COVID-19 pandemic: one-year experience Open
Hematopoietic stem cell transplantation (HSCT) is a life-saving procedure for oncological, hematological and non-malignant disorders.Despite global trend for a decrease of transplantation activity in view of the COVID-19 pandemic, we tried…
Differential diagnosis of myelopathy in a patient with relapsed acute lymphoblastic leukemia Open
Leukemia-associated myelopathy is a rare but still underestimated complication.It can be of different etiology, associated with both underlying disease and its specific treatment.It requires differential diagnosis with funicular myelosis, …
Влияние патриотического воспитания на образ патриота среди молодёжи (на примере Ярославской области) Open
In modern conditions of globalization and the introduction of the Internet into the daily life of young people, there is a blurring of the value of patriotism in the mass consciousness of young people. This process takes place in the time …
Long-term goals in the treatment of chronic graft-versus-host disease after matched allogeneic hematopoietic stem cell transplantation Open
Chronic graft-versus-host disease (cGvHD) is a common complication of allogeneic hematopoietic stem cell transplantation.Its incidence varies from 10% to 80% according to the type of prophylaxis, type of the donor and other risk factors.Al…
View article: Achievements and Challenges of Evidence-Based Medicine in Hematopoietic Stem Cell Transplantation: An Analysis of Single-Center and Multicenter Trials
Achievements and Challenges of Evidence-Based Medicine in Hematopoietic Stem Cell Transplantation: An Analysis of Single-Center and Multicenter Trials Open
Randomized multicenter trials in the area of hematopoietic stem cell transplantation (HSCT) face considerable challenges, therefore, their amount is relatively small. Most clinical guidelines are based on the data of multicenter registry s…
Successful treatment of relapsed/refractory B-Acute lymphoblastic leukemia with Inotuzumab ozogamicin after blinatumomab failure Open
Blinatumomab, a bispecific T-cell engaging CD3-CD19 antibody, is highly effective in patients with relapsed/refractory (R/R) B-cell acute lymphoblastic leukemia (ALL) even after allogeneic hematopoietic stem cell transplantation (allo-HSCT…
Randomized study between thymoglobulin and posttransplant cyclophosphamide in patients with chronic myeloid neoplasms undergoing unrelated allogeneic stem cell transplantation Open
Despite growing evidence on the use of posttransplantation cyclophosphamide (PTCY) in matched unrelated transplantation in acute leukemia patients, prospective evidence to support this type of prophylaxis in myelodysplastic syndrome (MDS),…
Severe Hypofunction of Allogeneic Hematopoietic Stem Cell Transplant in Patients with Oncohematological Diseases: Incidence, Risk Factors, and Outcomes Open
Aim. Based on strict criteria, to assess incidence, pretransplantation risk factors, and outcomes of severe hypofunction of graft, i.e. poor graft function (sPGF), following allogeneic hematopoietic stem cell transplantation (allo-HSCT) in…