Anna Spiridonova
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Time-Dependent Shifts in Intestinal Bacteriome, Klebsiella Colonization and Incidence of Antibiotic-Resistance Genes after Allogeneic Hematopoietic Stem Cell Transplantation Open
Dose-intensive cytostatic therapy and antibiotic treatment in allogeneic hematopoietic stem cell transplantation (allo-HSCT) cause severe abnormalities in a composition of gut microbiota as well as the emergence of antibiotic resistance. T…
The effectiveness of biapenem in the treatment of sepsis Open
The objective was to evaluate the clinical effectiveness and safety of biapenem (Bianem–AF drug) in the treatment of severe forms of infection in ICU patients. Materials and methods . The prospective observational study. At the first stage…
Microbiological monitoring in a urological hospital as a method for control of antibiotic resistance of uropathogens Open
BACKGROUND: A rational choice of antibacterial therapy for hospital infections is a condition for successful treatment of patients. AIM: The aim of this study is a comparative assessment of the species composition of pathogens and the leve…
Rationale for choosing a spacer at the first treatment stage for late deep periprosthetic knee joint infection Open
Background Periprosthetic infection develops in 0.5 to 5.0 % of cases after knee replacement, which is a social and economic problem. The most common causes of periprosthetic infection are methicillin-resistant staphylococcus aureus (MRSA)…
View article: Combined Use of Antimicrobial Peptides with Antiseptics against Multidrug-Resistant Bacteria: Pros and Cons
Combined Use of Antimicrobial Peptides with Antiseptics against Multidrug-Resistant Bacteria: Pros and Cons Open
Antimicrobial peptides (AMPs) are acknowledged as a promising template for designing new antimicrobials. At the same time, existing toxicity issues and limitations in their pharmacokinetics make topical application one of the less complica…
Hemolytic Activity, Cytotoxicity, and Antimicrobial Effects of Silver Nanoparticles Conjugated with Lincomycin or Cefazolin Open
The overuse of antibiotics has led to the emergence of resistant bacteria. A good alternative is silver nanoparticles, which have antibacterial activity against Gram-negative and Gram-positive bacteria, including multidrug-resistant strain…
Bioinformatics Analysis of Protein Homologues of Magnetotactic Bacteria Magnetosome Island Proteins in Human Proteome Open
Background. The number of biogenic magnetic nanoparticles (BMN), present in human organs and tissues in the form of magnetite (ferrimagnetic iron oxide), increases in oncological and neurodegenerative diseases. Therefore, the study of homo…
Incidence of Common Herpesviruses in Colonic Mucosal Biopsies Following Hematopoietic Stem Cell Transplantation Open
Intestinal complications are common after allogeneic hematopoietic stem cell transplantation (allo-HSCT). However, only scarce data concern herpesvirus incidence in the colonic mucosa post-HSCT. Our purpose was to assess the frequency and …
Spectrum of bronchoalveolar bacterial microbiota following hematopoietic stem cell transplantation: age dependence and microbiota shifts Open
In healthy persons, lung microbiota shows close correlations with microbial landscape of upper respiratory tract.However, pronounced changes of lung microbiota are revealed by analysis of bronchoalveolar lavage (BAL) in severe pneumonias a…
Microbiota of nasal cavity in sinusitis following hematopoietic stem cell transplantation Open
Hematopoietic stem cell transplantation (HSCT) is often accompanied by infectious complications.The aim of this study was a comparative evaluation of facultative anaerobic microbiota members of nasal and paranasal cavity in sinusitis, whic…
Journey of a hematopoietic stem cell transplantation center through COVID-19 pandemic: one-year experience Open
Hematopoietic stem cell transplantation (HSCT) is a life-saving procedure for oncological, hematological and non-malignant disorders.Despite global trend for a decrease of transplantation activity in view of the COVID-19 pandemic, we tried…
Hemolytic Activity, Cytotoxicity, and Antimicrobial Effects of Human Albumin- and Polysorbate-80-Coated Silver Nanoparticles Open
In this study, we aimed to develop a technique for colloidal silver nanoparticle (AgNP) modification in order to increase their stability in aqueous suspensions. For this purpose, 40-nm spherical AgNPs were modified by the addition of eith…
Pattern of circulating SARS‐CoV‐2‐specific antibody‐secreting and memory B‐cell generation in patients with acute COVID‐19 Open
Objectives To predict the spread of coronavirus disease (COVID‐19), information regarding the immunological memory for disease‐specific antigens is necessary. The possibility of reinfection, as well as the efficacy of vaccines for COVID‐19…
Microbiological monitoring of causative agents of nosocomial infection in the urological clinic Open
The analysis of the results of microbiological examination of urine samples of 1022 patients (559 women and 463 men) who were hospitalized at the urological clinic of the I.P. Pavlov First Saint Petersburg State Medical University in perio…
Аntibacterial inorganic agents: efficiency of using multicomponent systems Open
Metal and metal oxide nanoparticles (NPs) are promising antibacterial agents. They have a broad antimicrobial activity against both Gram-positive and Gram-negative bacteria, viruses, and protozoans. The use of NPs reduces the possibility o…
Factors of bacteriuria in children and young adults following hematopoietic stem cell transplantation Open
Presence of bacteriuria and urinary microbiota composition is an important index of immunocompromised conditions. These parameters are scarcely studied in patients undergoing hematopoietic stem cell transplantation (HSCT). The aim of this …
Common bacterial cultures from oral mucosa after hematopoietic stem cell transplantation: dependence on the patient characteristics and therapeutic factors Open
Normal aerobic and facultative anaerobic microbiota colonizing oral mucosa is usually identified at clinical laboratories.Its composition may be important index of immunocompromised conditions.These parameters are scarcely studied in patie…
The role of odontogenic infection role as a medical justification of planning the individual prevention programs in childbearing age women Open
Relevance: odontogenic infection plays an important role in the development of pregnancy complications, often causing premature birth of the child, as well as limiting its growth and development. According to studies Figueiredo C., Rosalem…
TIME-KILL ASSAY: AN EFFICACY OF SYNERGY BETWEEN CARBAPENEMS AND CLODRONIC ACID Open
Currently, a search for augmenting antibiotics activity is still crucial due to elevated frequency of detecting carbapenem-resistant Gran-positive bacterial isolates. To resolve this, it might be reasonable to combine carbapenems metal-â-l…
THE EFFECT OF SUB-BACTERICIDAL DOSES OF ANTISEPTICS ON DNA AND PHENOTYPIC MARKERS OF VIRULENCE OF MICROORGANISMS Open
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