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View article: Prognostic significance of deep sequencing for analysis of measurable residual disease in acute myeloid leukemia with <i>NPM1</i> mutation
Prognostic significance of deep sequencing for analysis of measurable residual disease in acute myeloid leukemia with <i>NPM1</i> mutation Open
In acute myeloid leukemia with NPM1 mutation, analysis of measurable residual disease (MRD) with reverse transcription quantitative polymerase chain reaction (RT-qPCR) is recommended for response assessment and monitoring after treatment. …
View article: Enhancing glioblastoma therapy: unveiling synergistic anticancer effects of Onalespib - radiotherapy combination therapy
Enhancing glioblastoma therapy: unveiling synergistic anticancer effects of Onalespib - radiotherapy combination therapy Open
Background Glioblastoma (GBM) is the deadliest form of brain cancer, impacting both adults and children, marked by exceptionally high morbidity and mortality rates, even with current standard treatments such as surgery, radiation therapy, …
View article: Acute Myeloid Leukemia With <i>NPM1</i> Mutation Presenting With Rapidly Progressing Hypereosinophilia
Acute Myeloid Leukemia With <i>NPM1</i> Mutation Presenting With Rapidly Progressing Hypereosinophilia Open
Hypereosinophilia presents a significant clinical challenge. We describe a case of severe, rapidly progressing hypereosinophilia, with the white blood cell count increasing from 40,000/μL to over 130,000/μL within days, and 70% eosinophils…
View article: Characterization of Pediatric Acute Myeloid Leukemia With t(7;12)(q36;p13)
Characterization of Pediatric Acute Myeloid Leukemia With t(7;12)(q36;p13) Open
Acute myeloid leukemia (AML) with t(7;12)(q36;p13) is a recurrent translocation in AML in infants or very young children and was recently included in the World Health Organization (WHO) Classification of Hematolymphoid Tumors. AML with t(7…
View article: Micro-costing of genetic diagnostics in acute leukemia in Sweden: from standard-of-care to whole-genome sequencing
Micro-costing of genetic diagnostics in acute leukemia in Sweden: from standard-of-care to whole-genome sequencing Open
In summary, WGS is currently more costly than SoC, however the cost can be reduced by utilizing laboratories with higher throughput and by the expected decline in cost of reagents. Our data provides guidance to decision-makers for the reso…
View article: Precision Diagnostics in Myeloid Malignancies: Development and Validation of a National Capture‐Based Gene Panel
Precision Diagnostics in Myeloid Malignancies: Development and Validation of a National Capture‐Based Gene Panel Open
Gene panel sequencing has become a common diagnostic tool for detecting somatically acquired mutations in myeloid neoplasms. However, many panels have restricted content, provide insufficient sensitivity levels, or lack clinically validate…
View article: Feasibility to use whole-genome sequencing as a sole diagnostic method to detect genomic aberrations in pediatric B-cell acute lymphoblastic leukemia
Feasibility to use whole-genome sequencing as a sole diagnostic method to detect genomic aberrations in pediatric B-cell acute lymphoblastic leukemia Open
Introduction The suitability of whole-genome sequencing (WGS) as the sole method to detect clinically relevant genomic aberrations in B-cell acute lymphoblastic leukemia (ALL) was investigated with the aim of replacing current diagnostic m…
View article: Infection with <i>Neoehrlichia mikurensis</i> promotes the development of malignant B‐cell lymphomas
Infection with <i>Neoehrlichia mikurensis</i> promotes the development of malignant B‐cell lymphomas Open
Summary The tick‐borne pathogen Neoehrlichia ( N. ) mikurensis is implicated in persistent infection of the vascular endothelium. B cells are crucial for the host defence to this infection. Chronic stimulation of B cells may result in B‐ce…
View article: An induced pluripotent stem cell t(7;12)(q36;p13) acute myeloid leukemia model shows high expression of <scp>MNX1</scp> and a block in differentiation of the erythroid and megakaryocytic lineages
An induced pluripotent stem cell t(7;12)(q36;p13) acute myeloid leukemia model shows high expression of <span>MNX1</span> and a block in differentiation of the erythroid and megakaryocytic lineages Open
Acute myeloid leukemia (AML) results from aberrant hematopoietic processes and these changes are frequently initiated by chromosomal translocations. One particular subtype, AML with translocation t(7;12)(q36;p13), is found in children diag…
View article: DNA Methylation Signatures Predict Cytogenetic Subtype and Outcome in Pediatric Acute Myeloid Leukemia (AML)
DNA Methylation Signatures Predict Cytogenetic Subtype and Outcome in Pediatric Acute Myeloid Leukemia (AML) Open
Pediatric acute myeloid leukemia (AML) is a heterogeneous disease composed of clinically relevant subtypes defined by recurrent cytogenetic aberrations. The majority of the aberrations used in risk grouping for treatment decisions are exte…
View article: Lactose drives <i>Enterococcus</i> expansion to promote graft-versus-host disease
Lactose drives <i>Enterococcus</i> expansion to promote graft-versus-host disease Open
Lactose can fuel GVHD Allogeneic hematopoietic cell transplantation (allo-HCT) is used to treat certain hematopoietic malignancies, but patients have a risk of developing graft-versus-host disease (GVHD). Stein-Thoeringer et al. performed …
View article: NOX2 inhibition reduces oxidative stress and prolongs survival in murine KRAS-induced myeloproliferative disease
NOX2 inhibition reduces oxidative stress and prolongs survival in murine KRAS-induced myeloproliferative disease Open
Mutations leading to constitutive RAS activation contribute in myeloid leukemogenesis. RAS mutations in myeloid cells are accompanied by excessive formation of reactive oxygen species (ROS), but the source of ROS and their role for the ini…
View article: Domination of the Gut Microbiota with Enterococcus Species Early after Allogeneic Bone Marrow Transplantation is an Important Contributor to the Development of Acute Graft-Versus-Host Disease (GHVD) in Mouse and Man
Domination of the Gut Microbiota with Enterococcus Species Early after Allogeneic Bone Marrow Transplantation is an Important Contributor to the Development of Acute Graft-Versus-Host Disease (GHVD) in Mouse and Man Open
Bacground: Increasing evidence suggests that the patientsÕ gut microbiota plays an important role in the development of acute GVHD. Enterococcus faecium dominates the gut microflora of a substantial portion of allo-HCT patients after trans…
View article: Nutritional Support From the Intestinal Microbiota Improves Hematopoietic Reconstitution after Bone Marrow Transplantation in Mice
Nutritional Support From the Intestinal Microbiota Improves Hematopoietic Reconstitution after Bone Marrow Transplantation in Mice Open
Bone-marrow transplantation (BMT) offers curative potential for patients with high-risk hematologic malignancies. However, the post-transplantation period is characterized by immunodeficiency and delayed immune reconstitution is an importa…
View article: Micro-ribonucleic acid-155 is a direct target of Meis1, but not a driver in acute myeloid leukemia
Micro-ribonucleic acid-155 is a direct target of Meis1, but not a driver in acute myeloid leukemia Open
Micro-ribonucleic acid-155 (miR-155) is one of the first described oncogenic miRNAs. Although multiple direct targets of miR-155 have been identified, it is not clear how it contributes to the pathogenesis of acute myeloid leukemia. We fou…
View article: The intestinal microbiota in allogeneic hematopoietic cell transplant and graft-versus-host disease
The intestinal microbiota in allogeneic hematopoietic cell transplant and graft-versus-host disease Open
Hematopoietic cell transplantation (HCT) is a critical treatment of patients with high-risk hematopoietic malignancies, hematological deficiencies, and other immune diseases. In allogeneic HCT (allo-HCT), donor-derived T cells recognize ho…