Anna Taubenberger
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GOT1 Inhibition Induces Extracellular Matrix Remodeling in Pancreatic Cancer Open
Pancreatic cancer cells rely on glutamine to sustain their survival in the stiff and poorly vascularized tumor microenvironment (TME). Inhibiting glutamic‐oxaloacetic transaminase 1 (GOT1) is a strategy to target glutamine metabolism and i…
Single‐Cell Morphomechanics of Prostate Cancer‐Associated Fibroblasts Identifies Distinct Features Associated with Patient Outcome Open
Tumor development and progression reshape the physical properties of the surrounding tumor microenvironment (TME), including its biomechanical traits. This is driven by a prominent cell type in the TME, cancer‐associated fibroblasts (CAFs)…
View article: Cells dynamically adapt their nuclear volumes and proliferation rates during single to multicellular transitions
Cells dynamically adapt their nuclear volumes and proliferation rates during single to multicellular transitions Open
Tumour development and progression are associated with biophysical alterations that manifest across multiple spatial scales, from the subcellular to multicellular tissue scale. While cells dynamically regulate their biophysical properties …
View article: Automated GMP-Compatible Production of Universal CAR Tregs for Organ-Targeted Tolerance Induction
Automated GMP-Compatible Production of Universal CAR Tregs for Organ-Targeted Tolerance Induction Open
Background Adoptive transfer of regulatory T cells (Tregs) has demonstrated safety, feasibility and early signs of efficacy in promoting immunological tolerance in inflammatory conditions such as graft-versus-host disease (GvHD). Chimeric …
Prior to Undergoing Epithelial to Mesenchymal Transition, Premalignant Cells Transiently Increase Tensile Forces at Cell-Cell and Cell-Matrix Adhesions Open
The weakening of Adherens Junctions (AJs) and Focal Adhesions (FAs) adhesiveness has been proposed to enable the initiation and progression of several types of cancer. Here we report that, prior to disassembling AJs and acquiring malignant…
Self-propagating wave drives morphogenesis of skull bones in vivo Open
Cellular motion is a key feature of tissue morphogenesis and is often driven by migration. However, migration need not explain cell motion in contexts where there is little free space or no obvious substrate, such as those found during org…
View article: Mechanical control of tissue growth during limb regeneration
Mechanical control of tissue growth during limb regeneration Open
The axolotl is a highly regenerative species, capable of restoring full limbs, regardless of the amputation site. However, the regeneration rate is adjusted with the plane of amputation along the proximo-distal (PD) axis, leading to equiva…
Prostate cancer associated fibroblasts have distinct morphomechanical features that are associated with patient outcome Open
Tumour development and progression reshape the physical properties of the surrounding tumour microenvironment (TME) including its biomechanical traits. This is driven by a prominent cell type in the TME, cancer associated fibroblasts (CAFs…
View article: De novo identification of universal cell mechanics gene signatures
De novo identification of universal cell mechanics gene signatures Open
Cell mechanical properties determine many physiological functions, such as cell fate specification, migration, or circulation through vasculature. Identifying factors that govern the mechanical properties is therefore a subject of great in…
View article: De novo identification of universal cell mechanics gene signatures
De novo identification of universal cell mechanics gene signatures Open
Cell mechanical properties determine many physiological functions, such as cell fate specification, migration, or circulation through vasculature. Identifying factors that govern the mechanical properties is therefore a subject of great in…
Heterogeneity of tumor biophysical properties and their potential role as prognostic markers Open
Progress in our knowledge of tumor regulatory mechanisms and complexity led to the understanding of the physical parameters of cancer cells and their microenvironment, including the mechanical, thermal, and electrical properties, solid str…
View article: The F-actin bundler SWAP-70 promotes tumor metastasis
The F-actin bundler SWAP-70 promotes tumor metastasis Open
Dynamic rearrangements of the F-actin cytoskeleton are a hallmark of tumor metastasis. Thus, proteins that govern F-actin rearrangements are of major interest for understanding metastasis and potential therapies. We hypothesized that the u…
View article: Manipulation of the nuclear envelope-associated protein SLAP during mammalian brain development affects cortical lamination and exploratory behavior
Manipulation of the nuclear envelope-associated protein SLAP during mammalian brain development affects cortical lamination and exploratory behavior Open
Here, we report the first characterization of the effects resulting from the manipulation of Soluble-Lamin Associated Protein (SLAP) expression during mammalian brain development. We found that SLAP localizes to the nuclear envelope and wh…
View article: Manipulation of the Nuclear Envelope-Associated Protein SLAP During Mammalian Brain Development Affects Cortical Lamination and Exploratory Behavior
Manipulation of the Nuclear Envelope-Associated Protein SLAP During Mammalian Brain Development Affects Cortical Lamination and Exploratory Behavior Open
Here we report the first characterization of the effects resulting from the manipulation of Soluble-Lamin Associated Protein (SLAP) expression during mammalian brain development. We found that SLAP localizes to the nuclear envelope and whe…
Self-propagating wave drives noncanonical antidurotaxis of skull bones in vivo Open
Cell motility is a key feature of tissue morphogenesis, and it is thought to be driven primarily by the active migration of individual cells or collectives. However, this model is unlikely to apply to cells lacking overt cytoskeletal, stab…
Self-propagating wave drives noncanonical antidurotaxis of skull bones in vivo Open
Cell motility is a key feature of tissue morphogenesis, and it is thought to be driven primarily by the active migration of individual cells or collectives. However, this model is unlikely to apply to cells lacking overt cytoskeletal, stab…
De novo identification of universal cell mechanics gene signatures Open
Cell mechanical properties determine many physiological functions, such as cell fate specification, migration, or circulation through vasculature. Identifying factors that govern the mechanical properties is therefore a subject of great in…
De novo identification of universal cell mechanics gene signatures Open
Cell mechanical properties determine many physiological functions, such as cell fate specification, migration, or circulation through vasculature. Identifying factors that govern the mechanical properties is therefore a subject of great in…
Precision Hydrogels for the Study of Cancer Cell Mechanobiology Open
Cancer progression is associated with extensive remodeling of the tumor microenvironment (TME), resulting in alterations of biochemical and biophysical cues that affect both cancer and stromal cells. In particular, the mechanical character…
Adipose cells and tissues soften with lipid accumulation while in diabetes adipose tissue stiffens Open
Adipose tissue expansion involves both differentiation of new precursors and size increase of mature adipocytes. While the two processes are well balanced in healthy tissues, obesity and diabetes type II are associated with abnormally enla…
View article: Adipose cells and tissues soften with lipid accumulation while in diabetes adipose tissue stiffens
Adipose cells and tissues soften with lipid accumulation while in diabetes adipose tissue stiffens Open
Adipose tissue expansion involves both differentiation of new precursors and size increase of mature adipocytes. While the two processes are well balanced in healthy tissues, obesity and diabetes type II are associated with abnormally enla…
Decoding Single Cell Morphology in Osteotropic Breast Cancer Cells for Dissecting Their Migratory, Molecular and Biophysical Heterogeneity Open
Breast cancer is a heterogeneous disease and the mechanistic framework for differential osteotropism among intrinsic breast cancer subtypes is unknown. Hypothesizing that cell morphology could be an integrated readout for the functional st…
View article: Correlative all-optical quantification of mass density and mechanics of subcellular compartments with fluorescence specificity
Correlative all-optical quantification of mass density and mechanics of subcellular compartments with fluorescence specificity Open
Quantitative measurements of physical parameters become increasingly important for understanding biological processes. Brillouin microscopy (BM) has recently emerged as one technique providing the 3D distribution of viscoelastic properties…
View article: Mapping Tumor Spheroid Mechanics in Dependence of 3D Microenvironment Stiffness and Degradability by Brillouin Microscopy
Mapping Tumor Spheroid Mechanics in Dependence of 3D Microenvironment Stiffness and Degradability by Brillouin Microscopy Open
Altered biophysical properties of cancer cells and of their microenvironment contribute to cancer progression. While the relationship between microenvironmental stiffness and cancer cell mechanical properties and responses has been previou…
View article: Mapping tumor spheroid mechanics in dependence of 3D microenvironment stiffness and degradability by Brillouin microscopy
Mapping tumor spheroid mechanics in dependence of 3D microenvironment stiffness and degradability by Brillouin microscopy Open
Altered biophysical properties of cancer cells and of their microenvironment contribute to cancer progression. While the relationship between microenvironmental stiffness and cancer cell mechanical properties and responses has been previou…
View article: Author response: Correlative all-optical quantification of mass density and mechanics of subcellular compartments with fluorescence specificity
Author response: Correlative all-optical quantification of mass density and mechanics of subcellular compartments with fluorescence specificity Open
Article Figures and data Abstract Editor's evaluation Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Quantitative measureme…
De novo identification of universal cell mechanics gene signatures Open
Cell mechanical properties determine many physiological functions, such as cell fate specification, migration, or circulation through vasculature. Identifying factors that govern the mechanical properties is therefore a subject of great in…