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View article: Characterization of ANGPTL3 deficiency and molecular mechanisms of ANGPTL3 deficiency induced hypolipidemia
Characterization of ANGPTL3 deficiency and molecular mechanisms of ANGPTL3 deficiency induced hypolipidemia Open
Johdanto: Väitöstyön tarkoituksena oli tutkia ANGPTL3 puutoksen aiheuttamia muutoksia ihmisessä rasva-aineenvaihdunnan osalta kliinisesti, populaatiotasolla sekä solutasolla. ANGPTL3 proteiinin on osoitettu säätelevän lipoproteiinilipaasin…
View article: Effects of angiopoietin-like protein 3 deficiency on postprandial lipid and lipoprotein metabolism
Effects of angiopoietin-like protein 3 deficiency on postprandial lipid and lipoprotein metabolism Open
The consequences of angiopoietin-like protein 3 (ANGPTL3) deficiency on postprandial lipid and lipoprotein metabolism has not been investigated in humans. We studied 7 homozygous (undetectable circulating ANGPTL3 levels) and 31 heterozygou…
View article: The role of ANGPTL3 in controlling lipoprotein metabolism
The role of ANGPTL3 in controlling lipoprotein metabolism Open
Angiopoietin-like protein 3 (ANGPTL3) is a secretory protein regulating plasma lipid levels via affecting lipoprotein lipase- and endothelial lipase-mediated hydrolysis of triglycerides and phospholipids. ANGPTL3-deficiency due to loss-of-…