Anna Tkachev
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View article: Blood Plasma Lipid Alterations Differentiating Psychotic and Affective Disorder Patients
Blood Plasma Lipid Alterations Differentiating Psychotic and Affective Disorder Patients Open
Psychotic and affective disorders, including schizophrenia (SCZ) and depression (MDD), affect millions of people globally. The overlapping symptoms of these diseases and the lack of objective diagnostic tools could lead to misdiagnosis. Re…
View article: Investigating the association of the plasma lipidomic profile with cognitive performance and genetic risk in the PsyCourse study
Investigating the association of the plasma lipidomic profile with cognitive performance and genetic risk in the PsyCourse study Open
Although lipid biology may play a key role in the pathophysiology of mental health disorders such as schizophrenia (SCZ) and bipolar disorder (BD), the nature of this interplay and how it could shape phenotypic presentation, including cogn…
View article: White matter lipidome alterations in the schizophrenia brain
White matter lipidome alterations in the schizophrenia brain Open
Numerous brain imaging studies have reported white matter alterations in schizophrenia, but the lipidome analysis of the corresponding tissue remains incomplete. In this study, we investigated the lipidome composition of six subcortical wh…
View article: Lipid Alteration Signature in the Blood Plasma of Individuals With Schizophrenia, Depression, and Bipolar Disorder
Lipid Alteration Signature in the Blood Plasma of Individuals With Schizophrenia, Depression, and Bipolar Disorder Open
Importance No clinically applicable diagnostic test exists for severe mental disorders. Lipids harbor potential as disease markers. Objective To define a reproducible profile of lipid alterations in the blood plasma of patients with schizo…
View article: Time-Dependent Effect of Sciatic Nerve Injury on Rat Plasma Lipidome
Time-Dependent Effect of Sciatic Nerve Injury on Rat Plasma Lipidome Open
Neuropathic pain is a condition affecting the quality of life of a substantial part of the population, but biomarkers and treatment options are still limited. While this type of pain is caused by nerve damage, in which lipids play key role…
View article: Ceramides: Shared Lipid Biomarkers of Cardiovascular Disease and Schizophrenia
Ceramides: Shared Lipid Biomarkers of Cardiovascular Disease and Schizophrenia Open
INTRODUCTION: Schizophrenia, although a debilitating mental illness, greatly affects individuals physical health as well. One of the leading somatic comorbidities associated with schizophrenia is cardiovascular disease, which has been esti…
View article: Long-Term Fluoxetine Administration Causes Substantial Lipidome Alteration of the Juvenile Macaque Brain
Long-Term Fluoxetine Administration Causes Substantial Lipidome Alteration of the Juvenile Macaque Brain Open
Fluoxetine is an antidepressant commonly prescribed not only to adults but also to children for the treatment of depression, obsessive-compulsive disorder, and neurodevelopmental disorders. The adverse effects of the long-term treatment re…
View article: Shorter Chain Triglycerides Are Negatively Associated with Symptom Improvement in Schizophrenia
Shorter Chain Triglycerides Are Negatively Associated with Symptom Improvement in Schizophrenia Open
Schizophrenia is a serious mental disorder requiring lifelong treatment. While medications are available that are effective in treating some patients, individual treatment responses can vary, with some patients exhibiting resistance to one…
View article: Reduced purine biosynthesis in humans after their divergence from Neandertals
Reduced purine biosynthesis in humans after their divergence from Neandertals Open
We analyze the metabolomes of humans, chimpanzees, and macaques in muscle, kidney and three different regions of the brain. Although several compounds in amino acid metabolism occur at either higher or lower concentrations in humans than i…
View article: Single-cell-resolution transcriptome map of human, chimpanzee, bonobo, and macaque brains
Single-cell-resolution transcriptome map of human, chimpanzee, bonobo, and macaque brains Open
Identification of gene expression traits unique to the human brain sheds light on the molecular mechanisms underlying human evolution. Here, we searched for uniquely human gene expression traits by analyzing 422 brain samples from humans, …
View article: Single-cell-resolution transcriptome map of human, chimpanzee, bonobo, and macaque brains
Single-cell-resolution transcriptome map of human, chimpanzee, bonobo, and macaque brains Open
Identification of gene expression traits unique to the human brain sheds light on the mechanisms of human cognition. Here we searched for gene expression traits separating humans from other primates by analyzing 88,047 cell nuclei and 422 …
View article: Metabolome signature of autism in the human prefrontal cortex
Metabolome signature of autism in the human prefrontal cortex Open
Autism spectrum disorder (ASD) is a common neurodevelopmental disorder with yet incompletely uncovered molecular determinants. Alterations in the abundance of low molecular weight compounds (metabolites) in ASD could add to our understandi…
View article: Kernel classification of connectomes based on earth mover's distance between graph spectra
Kernel classification of connectomes based on earth mover's distance between graph spectra Open
In this paper, we tackle a problem of predicting phenotypes from structural connectomes. We propose that normalized Laplacian spectra can capture structural properties of brain networks, and hence graph spectral distributions are useful fo…