Anna Tommasi
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View article: Efficient nonviral integration of large transgenes into human T cells using Cas9-CLIPT
Efficient nonviral integration of large transgenes into human T cells using Cas9-CLIPT Open
View article: Label free metabolic imaging to enhance the efficacy of chimeric antigen receptor T cell therapy
Label free metabolic imaging to enhance the efficacy of chimeric antigen receptor T cell therapy Open
Chimeric antigen receptor (CAR) T cell therapy for solid tumors is challenging not only because of the immunosuppressive tumor microenvironment, but also because of a complex manufacturing process that is difficult to monitor. Manufacturin…
View article: Metabolic priming of GD2 TRAC-CAR T cells during manufacturing promotes memory phenotypes while enhancing persistence
Metabolic priming of GD2 TRAC-CAR T cells during manufacturing promotes memory phenotypes while enhancing persistence Open
Manufacturing chimeric antigen receptor (CAR) T cell therapies is complex, with limited understanding of how medium composition impacts T cell phenotypes. CRISPR-Cas9 ribonucleoproteins can precisely insert a CAR sequence while disrupting …
View article: Label free metabolic imaging to enhance the efficacy of Chimeric Antigen Receptor T cell therapy
Label free metabolic imaging to enhance the efficacy of Chimeric Antigen Receptor T cell therapy Open
Chimeric antigen receptor (CAR) T cell therapy for solid tumors remains challenging due to the complex manufacturing process and the immunosuppressive tumor microenvironment. The manufacturing condition directly impacts CAR T cell yield, p…
View article: Metabolic priming of GD2<i>TRAC</i>-CAR T cells during manufacturing promotes memory phenotypes while enhancing persistence
Metabolic priming of GD2<i>TRAC</i>-CAR T cells during manufacturing promotes memory phenotypes while enhancing persistence Open
Manufacturing Chimeric Antigen Receptor (CAR) T cell therapies is complex, with limited understanding of how media composition impact T-cell phenotypes. CRISPR/Cas9 ribonucleoproteins can precisely insert a CAR sequence while disrupting th…
View article: Targeting autophagy sensitises lung cancer cells to Src family kinase inhibitors
Targeting autophagy sensitises lung cancer cells to Src family kinase inhibitors Open
Lung cancer is the main cancer killer in both men and women, mostly due to the rapid development of drug resistant metastatic disease. Here, we evaluate the potential involvement of SRC family kinases (SFK) in lung cancer biology and asses…