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View article: During acute graft versus host disease CD28 deletion in donor CD8<sup>+</sup>, but not CD4<sup>+</sup>, T cells maintain antileukemia responses in mice
During acute graft versus host disease CD28 deletion in donor CD8<sup>+</sup>, but not CD4<sup>+</sup>, T cells maintain antileukemia responses in mice Open
Donor lymphocyte infusions together with allogeneic hematopoietic stem cell transplantation are routinely used as second‐line treatment for hematological malignancies. Mature T cells in the graft crucially mediate a graft versus leukemia (…
View article: Differential requirement for CD28 co-stimulation on donor T cell subsets in mouse models of acute graft versus host disease and graft versus tumour effect
Differential requirement for CD28 co-stimulation on donor T cell subsets in mouse models of acute graft versus host disease and graft versus tumour effect Open
Hematopoietic stem cell transplantation is a curative therapy for malignant diseases of the haematopoietic system. The patients first undergo chemotherapy or irradiation therapy which depletes the majority of tumour cells before they recei…
View article: CD28 Costimulation of T Helper 1 Cells Enhances Cytokine Release In Vivo
CD28 Costimulation of T Helper 1 Cells Enhances Cytokine Release In Vivo Open
Compared to naive T cells, differentiated T cells are thought to be less dependent on CD28 costimulation for full activation. To revisit the role of CD28 costimulation in mouse T cell recall responses, we adoptively transferred in vitro ge…
View article: Protection of Mice from Acute Graft-versus-Host Disease Requires CD28 Co-stimulation on Donor CD4+ Foxp3+ Regulatory T Cells
Protection of Mice from Acute Graft-versus-Host Disease Requires CD28 Co-stimulation on Donor CD4+ Foxp3+ Regulatory T Cells Open
Acute graft-versus-host disease (aGvHD) is a major cause of morbidity and mortality after allogeneic hematopoietic stem cell plus T cell transplantation (allo-HSCT). In this study, we investigated the requirement for CD28 co-stimulation of…