Anna V. Ignatochkina
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View article: Trypanosome mRNA recapping is triggered by hypermethylation originating from cap 4
Trypanosome mRNA recapping is triggered by hypermethylation originating from cap 4 Open
RNA methylation adjacent to the 5′ cap plays a critical role in controlling mRNA stability and protein synthesis. In trypanosomes the 5′-terminus of mRNA is protected by hypermethylated cap 4. Trypanosomes encode a cytoplasmic recapping en…
View article: Structural and mutational analysis of archaeal ATP-dependent RNA ligase identifies amino acids required for RNA binding and catalysis
Structural and mutational analysis of archaeal ATP-dependent RNA ligase identifies amino acids required for RNA binding and catalysis Open
An ATP-dependent RNA ligase from Methanobacterium thermoautotrophicum (MthRnl) catalyzes intramolecular ligation of single-stranded RNA to form a closed circular RNA via covalent ligase-AMP and RNA-adenylylate intermediate. Here, we report…