Anna V. Protasio
YOU?
Author Swipe
View article: Interactions between placental Hofbauer cells and <i>L. monocytogenes</i> change throughout gestation
Interactions between placental Hofbauer cells and <i>L. monocytogenes</i> change throughout gestation Open
Hofbauer cells (HBCs) are extraembryonic macrophages generated de novo within the human placenta. In this study, we explored how the properties of HBCs change throughout gestation. Our analysis revealed transcriptomic differences between f…
Horizontal transfer of a LINE-RTE retrotransposon among parasite, host, prey and environment Open
Background Horizontal transfer of transposable elements is both impactful, owing to the subsequent transposition burst, and insightful, providing information on organisms’ evolutionary history. In eukaryotes, horizontal gene transfer (HGT)…
View article: Evolutionary analysis of genome-specific duplications in flatworm genomes
Evolutionary analysis of genome-specific duplications in flatworm genomes Open
Platyhelminthes, also known as flatworms, is a phylum of bilaterian invertebrates infamous for their parasitic representatives. The classes Cestoda, Monogenea, and Trematoda comprise parasitic helminths inhabiting multiple hosts, including…
View article: Subtelomeric plasticity contributes to gene family expansion in the human parasitic flatworm Schistosoma mansoni
Subtelomeric plasticity contributes to gene family expansion in the human parasitic flatworm Schistosoma mansoni Open
Background The genomic region that lies between the telomere and chromosome body, termed the subtelomere, is heterochromatic, repeat-rich, and frequently undergoes rearrangement. Within this region, large-scale structural changes enable ge…
Large-scale proteomic analysis of T. spiralis muscle-stage ESPs identifies a novel upstream motif for in silico prediction of secreted products Open
The Trichinella genus contains parasitic nematodes capable of infecting a wide range of hosts including mammals, birds and reptiles. Like other helminths, T. spiralis secretes a complex mixture of bioactive molecules capable of modulating …
stepRNA: Identification of Dicer cleavage signatures and passenger strand lengths in small RNA sequences Open
The enzyme Dicer is a component of many small RNA (sRNA) pathways involved in RNA processing for post-transcriptional regulation, anti-viral response and control of transposable elements. Cleavage of double-stranded RNA by Dicer produces a…
Large-scale proteomic analysis of T. spiralis muscle-stage ESPs identifies a novel upstream motif for <i>in silico</i> prediction of secreted products Open
The Trichinella genus contains parasitic nematodes capable of infecting a wide range of hosts including mammals, birds and reptiles. Like other helminths, T. spiralis secretes a complex mixture of bioactive molecules capable of modulating …
Correction: MiR-277/4989 regulate transcriptional landscape during juvenile to adult transition in the parasitic helminth Schistosoma mansoni Open
[This corrects the article DOI: 10.1371/journal.pntd.0005559.].
A bioactive phlebovirus-like envelope protein in a hookworm endogenous virus Open
Endogenous viral elements (EVEs), accounting for 15% of our genome, serve as a genetic reservoir from which new genes can emerge. Nematode EVEs are particularly diverse and informative of virus evolution. We identify Atlas virus—an intact …
View article: A protease-activatable luminescent biosensor and reporter cell line for authentic SARS-CoV-2 infection
A protease-activatable luminescent biosensor and reporter cell line for authentic SARS-CoV-2 infection Open
Efforts to define serological correlates of protection against COVID-19 have been hampered by the lack of a simple, scalable, standardised assay for SARS-CoV-2 infection and antibody neutralisation. Plaque assays remain the gold standard, …
Additional file 6 of A beginner’s guide to manual curation of transposable elements Open
Additional file 6. Videocast showing a selection of Unix commands to assist the handling of FASTA flies.
Additional file 5 of A beginner’s guide to manual curation of transposable elements Open
Additional file 5. Videocast showing how to split a multiple sequence alignment in AliView.
Additional file 4 of A beginner’s guide to manual curation of transposable elements Open
Additional file 4. Videocast showing the process of manual curation of a multiple sequence alignment from a LINE family.
Additional file 2 of A beginner’s guide to manual curation of transposable elements Open
Additional file 2. Videocast showing how to run “make_fasta_from_blast” and how to make multiple sequence alignments.
Additional file 3 of A beginner’s guide to manual curation of transposable elements Open
Additional file 3. Videocast showing the process of manual curation of a multiple sequence alignment from a LTR family.
A bioactive phlebovirus-like envelope protein in a hookworm endogenous retrovirus Open
Endogenous retroviruses (ERVs), accounting for 14% of our genome, serve as a genetic reservoir from which new genes can emerge. Nematode ERVs are particularly diverse and informative of retrovirus evolution. We identify Atlas virus – a nov…
Mapping Rora expression in resting and activated CD4+ T cells Open
The transcription factor Rora has been shown to be important for the development of ILC2 and the regulation of ILC3, macrophages and Treg cells. Here we investigate the role of Rora across CD4+ T cells in general, but with an emphasis on T…
View article: A protease-activatable luminescent biosensor and reporter cell line for authentic SARS-CoV-2 infection
A protease-activatable luminescent biosensor and reporter cell line for authentic SARS-CoV-2 infection Open
Efforts to define serological correlates of protection against COVID-19 have been hampered by the lack of a simple, scalable, standardised assay for SARS-CoV-2 infection and antibody neutralisation. Plaque assays remain the gold standard, …
Screening of a Library of Recombinant <i>Schistosoma mansoni</i> Proteins With Sera From Murine and Human Controlled Infections Identifies Early Serological Markers Open
Background Schistosomiasis is a major global health problem caused by blood-dwelling parasitic worms, which is currently tackled primarily by mass administration of the drug praziquantel. Appropriate drug treatment strategies are informed …
Transcriptome of the parasitic flatworm Schistosoma mansoni during intra-mammalian development Open
Schistosomes are parasitic blood flukes that survive for many years within the mammalian host vasculature. How the parasites establish a chronic infection in the hostile bloodstream environment, whilst evading the host immune response is p…
View article: Antagonism of PP2A is an independent and conserved function of HIV-1 Vif and causes cell cycle arrest
Antagonism of PP2A is an independent and conserved function of HIV-1 Vif and causes cell cycle arrest Open
The seminal description of the cellular restriction factor APOBEC3G and its antagonism by HIV-1 Vif has underpinned two decades of research on the host-virus interaction. We recently reported that HIV-1 Vif is also able to degrade the PPP2…
View article: Author response: Antagonism of PP2A is an independent and conserved function of HIV-1 Vif and causes cell cycle arrest
Author response: Antagonism of PP2A is an independent and conserved function of HIV-1 Vif and causes cell cycle arrest Open
Article Figures and data Abstract Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract The seminal description of the cellular re…
View article: TASOR is a pseudo-PARP that directs HUSH complex assembly and epigenetic transposon control
TASOR is a pseudo-PARP that directs HUSH complex assembly and epigenetic transposon control Open
Summary The Human Silencing Hub (HUSH) complex epigenetically represses retroviruses, transposons and genes in vertebrates. HUSH therefore maintains genome integrity and is central in the interplay between intrinsic immunity, transposable …
View article: Peptides Derived of Kunitz-Type Serine Protease Inhibitor as Potential Vaccine Against Experimental Schistosomiasis
Peptides Derived of Kunitz-Type Serine Protease Inhibitor as Potential Vaccine Against Experimental Schistosomiasis Open
Schistosomiasis is a significant public health problem in sub-Saharan Africa, China, Southeast Asia, and regions of South and Central America affecting about 189 million people. Kunitz-type serine protease inhibitors have been identified a…
Antagonism of PP2A is an independent and conserved function of HIV-1 Vif and causes cell cycle arrest Open
The seminal description of cellular restriction factor APOBEC3G and its antagonism by HIV-1 Vif has underpinned two decades of research on the host-virus interaction. As well as APOBEC3G and its homologues, however, we have recently discov…
Transcriptome of the parasitic flatworm <i>Schistosoma mansoni</i> during intra-mammalian development Open
Schistosomes are parasitic blood flukes that survive for many years within the mammalian host vasculature. How the parasites establish a chronic infection in the hostile bloodstream environment, whilst evading the host immune response is p…
<i>Rora</i> regulates activated T helper cells during inflammation Open
The transcription factor Rora has been shown to be important for the development of ILC2 and the regulation of ILC3, macrophages and Treg cells. Here we investigate the role of Rora across CD4+ T cells, both in vitro as well as in the cont…