Anna van Rhenen
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View article: Venetoclax plus hypomethylating agents as a bridge to transplant or donor lymphocyte infusion in relapsed/refractory acute myeloid leukemia
Venetoclax plus hypomethylating agents as a bridge to transplant or donor lymphocyte infusion in relapsed/refractory acute myeloid leukemia Open
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View article: Morning administration of anthracyclines is associated with a lower risk of cancer therapy-related cardiac dysfunction
Morning administration of anthracyclines is associated with a lower risk of cancer therapy-related cardiac dysfunction Open
Aims Pre-clinical studies point towards an administration time-dependency of anthracycline-induced cancer therapy-related cardiac dysfunction (CTRCD). This retrospective study aimed to investigate the association between time-of-day of AC …
View article: Heart Failure in Patients with Acute Myeloid Leukemia (AML) Treated with Anthracycline Agents During Remission Induction Therapy: A Systematic Review and Meta-Analysis
Heart Failure in Patients with Acute Myeloid Leukemia (AML) Treated with Anthracycline Agents During Remission Induction Therapy: A Systematic Review and Meta-Analysis Open
Patients with acute myeloid leukemia (AML) are at high risk of cardiovascular disease, particularly heart failure. Anthracyclines are integral to remission induction in patients eligible for intensive treatment and well-known for their ass…
View article: Management of disease progression after autologous hematopoietic stem cell transplantation in systemic sclerosis: Results from an international questionnaire-based study
Management of disease progression after autologous hematopoietic stem cell transplantation in systemic sclerosis: Results from an international questionnaire-based study Open
Our study benchmarks the unique combined experiences of post-AHSCT management among SSc experts. We summarize preferences regarding definition of AHSCT failure and progression after response, as well as approach to diagnostic work-up and t…
View article: The association between hospital volume and overall survival in adult AML patients treated with intensive chemotherapy
The association between hospital volume and overall survival in adult AML patients treated with intensive chemotherapy Open
View article: Rationale and design of the HOVON 170 DLBCL-ANTICIPATE trial: preventing anthracycline-induced cardiac dysfunction with dexrazoxane
Rationale and design of the HOVON 170 DLBCL-ANTICIPATE trial: preventing anthracycline-induced cardiac dysfunction with dexrazoxane Open
View article: Post-intrathecal chemotherapy-related paraplegia syndrome in hematological cancer patients: A systematic review
Post-intrathecal chemotherapy-related paraplegia syndrome in hematological cancer patients: A systematic review Open
Background Intrathecal (IT) chemotherapy is essential in treating hematological malignancies, but it can lead to ascending paraplegia, a condition that currently lacks clear management guidelines. Methods We conducted a systematic review, …
View article: Midostaurin added to 10-day decitabine, for patients unfit for intensive chemotherapy with AML and higher risk MDS, irrespective of FLT3 mutational status, does not improve outcome
Midostaurin added to 10-day decitabine, for patients unfit for intensive chemotherapy with AML and higher risk MDS, irrespective of FLT3 mutational status, does not improve outcome Open
The treatment of older patients with acute myeloid leukemia (AML) considered unfit for receiving intensive chemotherapy is challenging. Based on the hypothesis that addition of the broad tyrosine kinase inhibitor (TKI) midostaurin could im…
View article: Intracardiac echocardiography‐guided biopsies for right‐sided intracardiac tumors: An optimized diagnostic algorithm and case illustrations
Intracardiac echocardiography‐guided biopsies for right‐sided intracardiac tumors: An optimized diagnostic algorithm and case illustrations Open
Intracardiac tumors, though uncommon, necessitate a swift and accurate diagnosis for personalized treatment and prognosis estimation. While multi‐modality imaging often determines the etiology of these cardiac masses, histological confirma…
View article: Regional disparities in the use of intensive chemotherapy for AML in the Netherlands: does it influence survival?
Regional disparities in the use of intensive chemotherapy for AML in the Netherlands: does it influence survival? Open
Objective Acute myeloid leukaemia (AML) prognosis is enhanced with intensive remission induction chemotherapy (ICT) in eligible patients. However, ICT eligibility perceptions may differ among healthcare professionals. This nationwide, popu…
View article: Efficacy and safety of daratumumab in pure red cell aplasia after allogeneic transplantation: Dutch real-world data
Efficacy and safety of daratumumab in pure red cell aplasia after allogeneic transplantation: Dutch real-world data Open
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View article: Management of Disease Progression after Autologous Hematopoietic Stem Cell Transplantation in Systemic Sclerosis: Results from an International Questionnaire-Based Study
Management of Disease Progression after Autologous Hematopoietic Stem Cell Transplantation in Systemic Sclerosis: Results from an International Questionnaire-Based Study Open
View article: P717: AG946, A PYRUVATE KINASE (PK) ACTIVATOR IMPROVES PK PROPERTIES AND RED BLOOD CELL (RBC) METABOLISM UPON EX VIVO TREATMENT OF RBCS FROM PATIENTS WITH MYELODYSPLASTIC SYNDROMES
P717: AG946, A PYRUVATE KINASE (PK) ACTIVATOR IMPROVES PK PROPERTIES AND RED BLOOD CELL (RBC) METABOLISM UPON EX VIVO TREATMENT OF RBCS FROM PATIENTS WITH MYELODYSPLASTIC SYNDROMES Open
Background: Myelodysplastic syndromes (MDS) consist of a heterogenous group of clonal myeloid malignancies, characterized by dysplasia, ineffective hematopoiesis and cytopenias. MDS patients frequently suffer from anemia. This directly aff…
View article: Anti-thymocyte globulin exposure in patients with diffuse cutaneous systemic sclerosis undergoing autologous haematopoietic stem cell transplantation
Anti-thymocyte globulin exposure in patients with diffuse cutaneous systemic sclerosis undergoing autologous haematopoietic stem cell transplantation Open
Introduction: Autologous haematopoietic stem cell transplantation improves event-free survival and lung function and reduces skin thickening in patients with progressive diffuse cutaneous systemic sclerosis. Anti-thymocyte globulin is a ke…
View article: AB0857 ANTI-THYMOCYTE GLOBULIN EXPOSURE IS ASSOCIATED WITH TREATMENT RESPONSE IN PATIENTS WITH DIFFUSE CUTANEOUS SYSTEMIC SCLEROSIS UNDERGOING AUTOLOGOUS HAEMATOPOIETIC STEM CELL TRANSPLANTATION
AB0857 ANTI-THYMOCYTE GLOBULIN EXPOSURE IS ASSOCIATED WITH TREATMENT RESPONSE IN PATIENTS WITH DIFFUSE CUTANEOUS SYSTEMIC SCLEROSIS UNDERGOING AUTOLOGOUS HAEMATOPOIETIC STEM CELL TRANSPLANTATION Open
View article: Graft engineering: how long can you wait, how low can you go, and pandemic readiness
Graft engineering: how long can you wait, how low can you go, and pandemic readiness Open
View article: Case report: A successful second autologous hematopoietic stem cell transplantation in refractory systemic sclerosis, with positive effect on skin involvement, pulmonary function and microcirculation
Case report: A successful second autologous hematopoietic stem cell transplantation in refractory systemic sclerosis, with positive effect on skin involvement, pulmonary function and microcirculation Open
Background Systemic sclerosis (SSc) is a complex autoimmune disease characterized by inflammation, vasculopathy and fibrosis of the skin and internal organs. Treatment with autologous hematopoietic cell transplantation (HCT) for progressiv…
View article: R-CEOP as first-line treatment for anthracycline-ineligible patients with diffuse large B-cell lymphoma
R-CEOP as first-line treatment for anthracycline-ineligible patients with diffuse large B-cell lymphoma Open
View article: Allogeneic Stem Cell Transplantation Platforms With Ex Vivo and In Vivo Immune Manipulations: Count and Adjust
Allogeneic Stem Cell Transplantation Platforms With Ex Vivo and In Vivo Immune Manipulations: Count and Adjust Open
Various allogeneic (allo) stem cell transplantation platforms have been developed over the last 2 decades. In this review we focus on the impact of in vivo and ex vivo graft manipulation on immune reconstitution and clinical outcome. Strat…
View article: A randomised, open-label trial to assess the optimal treatment strategy in early diffuse cutaneous systemic sclerosis: the UPSIDE study protocol
A randomised, open-label trial to assess the optimal treatment strategy in early diffuse cutaneous systemic sclerosis: the UPSIDE study protocol Open
Introduction Systemic sclerosis (SSc) is a chronic, autoimmune connective tissue disease associated with high morbidity and mortality, especially in diffuse cutaneous SSc (dcSSc). Currently, there are several treatments available in early …
View article: αβ T-cell graft depletion for allogeneic HSCT in adults with hematological malignancies
αβ T-cell graft depletion for allogeneic HSCT in adults with hematological malignancies Open
We conducted a multicenter prospective single-arm phase 1/2 study that assesses the outcome of αβ T-cell depleted allogeneic hematopoietic stem cell transplantation (allo-HSCT) of peripheral blood derived stem cells from matched related, o…
View article: Correction: Lenalidomide added to standard intensive treatment for older patients with AML and high-risk MDS
Correction: Lenalidomide added to standard intensive treatment for older patients with AML and high-risk MDS Open
View article: Lenalidomide added to standard intensive treatment for older patients with AML and high-risk MDS
Lenalidomide added to standard intensive treatment for older patients with AML and high-risk MDS Open
View article: Cancer Therapy-Related Cardiac Dysfunction of Nonanthracycline Chemotherapeutics
Cancer Therapy-Related Cardiac Dysfunction of Nonanthracycline Chemotherapeutics Open
Cancer therapy-related cardiac dysfunction (CTRCD) is one of the most concerning cardiovascular side effects of cancer treatment. Important reviews within the field of cardio-oncology have described various agents to be associated with a h…
View article: Fludarabine exposure in the conditioning prior to allogeneic hematopoietic cell transplantation predicts outcomes
Fludarabine exposure in the conditioning prior to allogeneic hematopoietic cell transplantation predicts outcomes Open
Fludarabine is the most frequently used agent in conditioning regimens for allogeneic hematopoietic cell transplantation (HCT). Body surface area–based dosing leads to highly variable fludarabine exposure. We studied the relation between f…
View article: Second autologous haematopoietic stem cell transplantation in systemic sclerosis—a case report
Second autologous haematopoietic stem cell transplantation in systemic sclerosis—a case report Open
of microvascular involvement, compared with a classical NVC pattern definition showing longer time to progression between different patterns [7].In our study we found very low levels of VEGF-A but high levels of E-Selectin and VCAM-1.A pla…
View article: IGFBP7 Induces Differentiation and Loss of Survival of Human Acute Myeloid Leukemia Stem Cells without Affecting Normal Hematopoiesis
IGFBP7 Induces Differentiation and Loss of Survival of Human Acute Myeloid Leukemia Stem Cells without Affecting Normal Hematopoiesis Open
Leukemic stem cells (LSCs) are thought to be the major cause of the recurrence of acute myeloid leukemia (AML) due to their potential for self-renewal. To identify therapeutic strategies targeting LSCs, while sparing healthy hematopoietic …
View article: Cardio-oncology: an overview on outpatient management and future developments
Cardio-oncology: an overview on outpatient management and future developments Open
View article: Improving early diagnosis of pulmonary infections in patients with febrile neutropenia using low-dose chest computed tomography
Improving early diagnosis of pulmonary infections in patients with febrile neutropenia using low-dose chest computed tomography Open
We performed a prospective study in patients with chemotherapy induced febrile neutropenia to investigate the diagnostic value of low-dose computed tomography compared to standard chest radiography. The aim was to compare both modalities f…