Anna Vind
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View article: “Homo est deus”: Reflections on Luther's Christology
“Homo est deus”: Reflections on Luther's Christology Open
In order to refresh scholarly discussions about Luther's Christology, his discourse on Christ is analyzed in the present article with reference to his humanist background and texts, where he attacks scholasticism, philosophy, and logic and…
View article: Mechanistic basis for potassium efflux–driven activation of the human NLRP1 inflammasome
Mechanistic basis for potassium efflux–driven activation of the human NLRP1 inflammasome Open
Nigericin, an ionophore derived from Streptomyces hygroscopicus , is arguably the most commonly used tool compound to study the NLRP3 inflammasome. Recent findings, however, showed that nigericin also activates the NLRP1 inflammasome in hu…
View article: ROS-induced ribosome impairment underlies ZAKα-mediated metabolic decline in obesity and aging
ROS-induced ribosome impairment underlies ZAKα-mediated metabolic decline in obesity and aging Open
The ribotoxic stress response (RSR) is a signaling pathway in which the p38- and c-Jun N-terminal kinase (JNK)–activating mitogen-activated protein kinase kinase kinase (MAP3K) ZAKα senses stalling and/or collision of ribosomes. Here, we s…
View article: Mechanistic basis for nigericin-induced NLRP1 inflammasome activation in human epithelial cells
Mechanistic basis for nigericin-induced NLRP1 inflammasome activation in human epithelial cells Open
Nigericin, an ionophore derived from Streptomyces hygroscopicus , is arguably the most commonly used tool compound to study the NLRP3 inflammasome. Recent findings, however, showed that nigericin also activates the NLRP1 inflammasome in hu…
View article: Rational Design of Covalent Kinase Inhibitors by an Integrated Computational Workflow (Kin-Cov)
Rational Design of Covalent Kinase Inhibitors by an Integrated Computational Workflow (Kin-Cov) Open
Covalent kinase inhibitors (CKIs) hold great promise for drug development. However, examples of computationally guided design of CKIs are still scarce. Here, we present an integrated computational workflow (Kin-Cov) for rational design of …
View article: Computational and Functional Analysis of Structural Features in the ZAKα Kinase
Computational and Functional Analysis of Structural Features in the ZAKα Kinase Open
The kinase ZAKα acts as the proximal sensor of translational impairment and ribotoxic stress, which results in the activation of the MAP kinases p38 and JNK. Despite recent insights into the functions and binding partners of individual pro…
View article: Autophagy-mediated control of ribosome homeostasis in oncogene-induced senescence- Reverse phase pos part
Autophagy-mediated control of ribosome homeostasis in oncogene-induced senescence- Reverse phase pos part Open
Oncogene-induced senescence (OIS) is a persistent anti-proliferative response regarded as a fail-safe mechanism, which protects against malignant transformation. Yet OIS has pro-tumorigenic effects through the secretion of a diverse group …
View article: Loss of USP10 from the ribosome interactome triggers autophagy-mediated degradation of ribosomes during oncogene-induced senescence - Reverse phase pos part
Loss of USP10 from the ribosome interactome triggers autophagy-mediated degradation of ribosomes during oncogene-induced senescence - Reverse phase pos part Open
Oncogene-induced senescence (OIS) is a persistent anti-proliferative response regarded as a fail-safe mechanism, which protects against malignant transformation. Yet OIS has pro-tumorigenic effects through the secretion of a diverse group …
View article: Loss of USP10 from the ribosome interactome triggers autophagy-mediated degradation of ribosomes during oncogene-induced senescence - Reverse phase pos part
Loss of USP10 from the ribosome interactome triggers autophagy-mediated degradation of ribosomes during oncogene-induced senescence - Reverse phase pos part Open
Oncogene-induced senescence (OIS) is a persistent anti-proliferative response regarded as a fail-safe mechanism, which protects against malignant transformation. Yet OIS has pro-tumorigenic effects through the secretion of a diverse group …
View article: Ribosome stalling is a signal for metabolic regulation by the ribotoxic stress response
Ribosome stalling is a signal for metabolic regulation by the ribotoxic stress response Open
Impairment of translation can lead to collisions of ribosomes, which constitute an activation platform for several ribosomal stress-surveillance pathways. Among these is the ribotoxic stress response (RSR), where ribosomal sensing by the M…
View article: Ribosomal stress-surveillance: three pathways is a magic number
Ribosomal stress-surveillance: three pathways is a magic number Open
Cells rely on stress response pathways to uphold cellular homeostasis and limit the negative effects of harmful environmental stimuli. The stress- and mitogen-activated protein (MAP) kinases, p38 and JNK, are at the nexus of numerous stres…
View article: ZAKα recognizes stalled ribosomes through partially redundant sensor domains. Vind et al
ZAKα recognizes stalled ribosomes through partially redundant sensor domains. Vind et al Open
Impairment of ribosome function activates the MAPKKK ZAK, leading to activation of mitogen-activated protein (MAP) kinases p38 and JNK and inflammatory signaling. The mechanistic basis for activation of this ribotoxic stress response (RSR)…
View article: GIGYF1/2-Driven Cooperation between ZNF598 and TTP in Posttranscriptional Regulation of Inflammatory Signaling
GIGYF1/2-Driven Cooperation between ZNF598 and TTP in Posttranscriptional Regulation of Inflammatory Signaling Open
Inflammatory signaling is restricted through degradation and the translational repression of cytokine mRNAs. A key factor in this regulation is tristetraprolin (TTP), an RNA-binding protein (RBP) that recruits RNA-destabilizing factors and…