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View article: Captopril restores microglial homeostasis and reverses ASD-like phenotype in a model of ASD induced by exposure in utero to anti-caspr2 IgG
Captopril restores microglial homeostasis and reverses ASD-like phenotype in a model of ASD induced by exposure in utero to anti-caspr2 IgG Open
Microglia play a crucial role in brain development, including synaptic pruning and neuronal circuit formation. Prenatal disruptions, such as exposure to maternal autoantibodies, can dysregulate microglial function and contribute to neurode…
View article: Preoperative network activity predicts the response to subthalamic DBS for Parkinson’s disease
Preoperative network activity predicts the response to subthalamic DBS for Parkinson’s disease Open
Quantitative imaging markers to aid in the selection of Parkinson’s disease (PD) patients for surgical interventions such as subthalamic nucleus deep brain stimulation (STN-DBS) are currently lacking. Using metabolic PET and network analys…
View article: An artificial intelligence-derived metabolic network predicts psychosis in Alzheimer’s disease
An artificial intelligence-derived metabolic network predicts psychosis in Alzheimer’s disease Open
The delusions and hallucinations that characterize Alzheimer’s disease psychosis (AD + P) are associated with violence towards caregivers and an accelerated cognitive and functional decline whose management relies on the utilization of med…
View article: Longitudinal network changes and phenoconversion risk in isolated REM sleep behavior disorder
Longitudinal network changes and phenoconversion risk in isolated REM sleep behavior disorder Open
Isolated rapid eye movement sleep behavior disorder is a prodrome of α-synucleinopathies. Using positron emission tomography, we assessed changes in Parkinson's disease-related motor and cognitive metabolic networks and caudate/putamen dop…
View article: Cognition‐related Network Organization in Parkinson's Disease with Mild Cognitive Impairment and Dementia
Cognition‐related Network Organization in Parkinson's Disease with Mild Cognitive Impairment and Dementia Open
Background The Parkinson's disease (PD) cognition‐related covariance pattern (PDCP) was derived from network analysis of metabolic positron emission tomography (PET). The expression score is a feasible imaging biomarker that correlates wit…
View article: Convergent olfactory circuits for courtship in<i>Drosophila</i>revealed by<i>ds</i>-Tango
Convergent olfactory circuits for courtship in<i>Drosophila</i>revealed by<i>ds</i>-Tango Open
Summary Animals exhibit sex-specific behaviors that are governed by sexually dimorphic circuits. One such behavior in male Drosophila melanogaster , courtship, is regulated by various sensory modalities, including olfaction. Here, we revea…
View article: Correlation between MUAC z‑score and the anthropometric indexes, weight and height, in the assessment of the nutritional status of pediatric inpatients
Correlation between MUAC z‑score and the anthropometric indexes, weight and height, in the assessment of the nutritional status of pediatric inpatients Open
Nutrition plays a crucial role in the growth of healthy children, and its role is particularly critical in pediatric patients to help increase response to treatment, reduce morbidity and mortality, improve quality of life, and reduce treat…
View article: An artificial intelligence-derived metabolic network predicts psychosis in Alzheimer’s disease
An artificial intelligence-derived metabolic network predicts psychosis in Alzheimer’s disease Open
Alzheimer’s Disease psychosis (AD + P) is characterized by accelerated cognitive decline and tau pathology. Through exploring the AD + P network (ADPN), the aim is to predict psychosis in AD and understand its mechanisms. Utilizing FDG PET…
View article: Bridging Machine Learning and Clinical Diagnosis: An Explainable Biomarker for ß-Amyloid PET Imaging
Bridging Machine Learning and Clinical Diagnosis: An Explainable Biomarker for ß-Amyloid PET Imaging Open
[18F]-florbetaben positron emission tomography (PET) imaging is an established marker of ß-Amyloid (Aß) that is being increasingly used to assess Aß deposition in AD. This study presents a novel, explainable machine learning-based biomarke…
View article: The Impact of Muscarinic Antagonism on Psychosis-Relevant Behaviors and Striatal [11C] Raclopride Binding in Tau Mouse Models of Alzheimer’s Disease
The Impact of Muscarinic Antagonism on Psychosis-Relevant Behaviors and Striatal [11C] Raclopride Binding in Tau Mouse Models of Alzheimer’s Disease Open
Psychosis that occurs over the course of Alzheimer’s disease (AD) is associated with increased caregiver burden and a more rapid cognitive and functional decline. To find new treatment targets, studies modeling psychotic conditions traditi…
View article: Disordered network structure and function in dystonia: pathological connectivity vs. adaptive responses
Disordered network structure and function in dystonia: pathological connectivity vs. adaptive responses Open
Primary dystonia is thought to emerge through abnormal functional relationships between basal ganglia and cerebellar motor circuits. These interactions may differ across disease subtypes and provide a novel biomarker for diagnosis and trea…
View article: Sporadic Creutzfeldt–Jakob disease is associated with reorganization of metabolic connectivity in a pathological brain network
Sporadic Creutzfeldt–Jakob disease is associated with reorganization of metabolic connectivity in a pathological brain network Open
Background and purpose Although sporadic Creutzfeldt–Jakob disease (sCJD) is a rare cause of dementia, it is critical to understand its functional networks as the prion protein spread throughout the brain may share similar mechanisms with …
View article: Disease specific and nonspecific metabolic brain networks in behavioral variant of frontotemporal dementia
Disease specific and nonspecific metabolic brain networks in behavioral variant of frontotemporal dementia Open
Behavioral variant of frontotemporal dementia (bvFTD) is common among young‐onset dementia patients. While bvFTD‐specific multivariate metabolic brain pattern (bFDRP) has been identified previously, little is known about its temporal evolu…
View article: Automated differential diagnosis of dementia syndromes using FDG PET and machine learning
Automated differential diagnosis of dementia syndromes using FDG PET and machine learning Open
Background Metabolic brain imaging with 2-[ 18 F]fluoro-2-deoxy-D-glucose positron emission tomography (FDG PET) is a supportive diagnostic and differential diagnostic tool for neurodegenerative dementias. In the clinic, scans are usually …
View article: Stereotyped Relationship Between Motor and Cognitive Metabolic Networks in Parkinson's Disease
Stereotyped Relationship Between Motor and Cognitive Metabolic Networks in Parkinson's Disease Open
Background Idiopathic Parkinson's disease (iPD) is associated with two distinct brain networks, PD‐related pattern (PDRP) and PD‐related cognitive pattern (PDCP), which correlate respectively with motor and cognitive symptoms. The relation…
View article: Disordered network structure and function in dystonia: Pathological connectivity vs. adaptive responses
Disordered network structure and function in dystonia: Pathological connectivity vs. adaptive responses Open
Primary dystonia is thought to emerge through abnormal functional relationships between basal ganglia and cerebellar motor circuits. These interactions may differ across disease subtypes and provide a novel biomarker for diagnosis and trea…
View article: In utero exposure to maternal anti–aquaporin-4 antibodies alters brain vasculature and neural dynamics in male mouse offspring
In utero exposure to maternal anti–aquaporin-4 antibodies alters brain vasculature and neural dynamics in male mouse offspring Open
The fetal brain is constantly exposed to maternal IgG before the formation of an effective blood-brain barrier (BBB). Here, we studied the consequences of fetal brain exposure to an antibody to the astrocytic protein aquaporin-4 (AQP4-IgG)…
View article: Adaptive and pathological connectivity responses in Parkinson’s disease brain networks
Adaptive and pathological connectivity responses in Parkinson’s disease brain networks Open
Functional imaging has been used extensively to identify and validate disease-specific networks as biomarkers in neurodegenerative disorders. It is not known, however, whether the connectivity patterns in these networks differ with disease…
View article: 101 Increased blood brain barrier permeability associates with increased hippocampal glucose metabolism in SLE
101 Increased blood brain barrier permeability associates with increased hippocampal glucose metabolism in SLE Open
Background Mechanisms for SLE-mediated cognitive impairment (SLE-CI) include autoantibodies and inflammatory molecules normally excluded from the brain by an intact blood brain barrier (BBB). However, the BBB permeability may be altered in…
View article: Adaptive and pathological connectivity responses in Parkinson’s disease brain networks
Adaptive and pathological connectivity responses in Parkinson’s disease brain networks Open
Functional imaging has been used extensively to identify and validate disease-specific networks as biomarkers in neurodegenerative disorders. It is not known, however, if connectivity patterns in these networks differ with disease progress…
View article: Parkinson's disease-related pattern (PDRP) identified using resting-state functional MRI: Validation study
Parkinson's disease-related pattern (PDRP) identified using resting-state functional MRI: Validation study Open
Spatial covariance mapping of brain activity has been used increasingly with metabolic imaging to detect and quantify abnormal disease patterns in patient populations. Metabolic topographies such as the Parkinson's disease-related pattern …
View article: Cognition-Related Functional Topographies in Parkinson’s Disease: Localized Loss of the Ventral Default Mode Network
Cognition-Related Functional Topographies in Parkinson’s Disease: Localized Loss of the Ventral Default Mode Network Open
Cognitive dysfunction in Parkinson’s disease (PD) is associated with increased expression of the PD cognition-related pattern (PDCP), which overlaps with the normal default mode network (DMN). Here, we sought to determine the degree to whi…
View article: Presentation and Treatment of cholinergic Crisis in the setting of Carbamate poisoning
Presentation and Treatment of cholinergic Crisis in the setting of Carbamate poisoning Open
The case details the acute onset of muscarinic poisoning with associated symptoms and long‐term complications, as a new readily available suicide tool that clinicians should be keen to, combined with the appropriate treatment so lifesaving…
View article: Advanced neuroimaging in neuropsychiatric systemic lupus erythematosus
Advanced neuroimaging in neuropsychiatric systemic lupus erythematosus Open
Purpose of review Neuropsychiatric lupus (NPSLE) comprises a disparate collection of syndromes affecting the central and peripheral nervous systems. Progress in the attribution of neuropsychiatric syndromes to SLE-related mechanisms and de…