Anna Webb
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View article: Shared requirement for MYC upstream super-enhancer region in tissue regeneration and cancer
Shared requirement for MYC upstream super-enhancer region in tissue regeneration and cancer Open
Cancer has been characterized as a wound that does not heal. Malignant cells are morphologically distinct from normal proliferating cells but have extensive similarities to tissues undergoing wound healing and/or regeneration. The mechanis…
View article: Golgi organization is a determinant of stem cell function in the small intestine
Golgi organization is a determinant of stem cell function in the small intestine Open
Cell-to-cell signalling between niche and stem cells regulates tissue regeneration. While the identity of many mediating factors is known, it is largely unknown whether stem cells optimize their receptiveness to niche signals according to …
View article: The protein kinase LKB1 promotes self‐renewal and blocks invasiveness in glioblastoma
The protein kinase LKB1 promotes self‐renewal and blocks invasiveness in glioblastoma Open
The role of liver kinase B1 (LKB1) in glioblastoma (GBM) development remains poorly understood. LKB1 may regulate GBM cell metabolism and has been suggested to promote glioma invasiveness. After analyzing LKB1 expression in GBM patient mRN…
View article: Fetal-like reversion in the regenerating intestine is regulated by mesenchymal Asporin
Fetal-like reversion in the regenerating intestine is regulated by mesenchymal Asporin Open
Epithelial tissues undergo fetal-like cellular reprogramming to regenerate after damage 1,2 . Although the mesenchyme and the extracellular matrix (ECM) play critical roles in tissue homeostasis and regeneration 2–5 , their role in repurpo…