Anna Welle
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A subset of <span>OPCs</span> do not express Olig2 during development which can be increased in the adult by brain injuries and complex motor learning Open
Oligodendrocyte precursor cells (OPCs) are uniformly distributed in the mammalian brain; however, their function is rather heterogeneous in respect to their origin, location, receptor/channel expression and age. The basic helix–loop–helix …
Brain injuries and complex motor learning suppress Olig2 in a subpopulation of oligodendrocyte precursor cells Open
Oligodendrocyte precursor cells (OPCs) are uniformly distributed in the mammalian brain, however their function is rather heterogeneous in respect to their origin, location, receptor/channel expression and age. The basic helix-loop-helix t…
Astrocytes and Microglia Exhibit Cell-Specific Ca2+ Signaling Dynamics in the Murine Spinal Cord Open
The spinal cord is the main pathway connecting brain and peripheral nervous system. Its functionality relies on the orchestrated activity of both neurons and glial cells. To date, most advancement in understanding the spinal cord inner mec…
View article: Epigenetic control of region‐specific transcriptional programs in mouse cerebellar and cortical astrocytes
Epigenetic control of region‐specific transcriptional programs in mouse cerebellar and cortical astrocytes Open
Astrocytes from the cerebral cortex (CTX) and cerebellum (CB) share basic molecular programs, but also form distinct spatial and functional subtypes. The regulatory epigenetic layers controlling such regional diversity have not been compre…
Identification and Characterization of Post-activated B Cells in Systemic Autoimmune Diseases Open
Autoimmune diseases (AID) such as systemic lupus erythematosus (SLE), primary Sjögren's syndrome (pSS), and rheumatoid arthritis (RA) are chronic inflammatory diseases in which abnormalities of B cell function play a central role. Although…
View article: Sodium chloride is an ionic checkpoint for human T <sub>H</sub> 2 cells and shapes the atopic skin microenvironment
Sodium chloride is an ionic checkpoint for human T <sub>H</sub> 2 cells and shapes the atopic skin microenvironment Open
Sodium chloride induces and amplifies human T H 2 cell responses, potentially shaping the atopic skin microenvironment.
Exploring cell type diversity by comprehensive epigenome and transcriptome analysis Open
The mammalian organism comprises hundreds of different, and highly specialized cell types. They share identical DNA sequences and yet differ in their phenotypes and functionalities. This cellular diversity is governed by regulatory mechani…
View article: Sodium chloride is an ionic checkpoint for human Th2 cell responses and shapes the atopic skin microenvironment
Sodium chloride is an ionic checkpoint for human Th2 cell responses and shapes the atopic skin microenvironment Open
One sentence summary Sodium is an ionic checkpoint for the induction and amplification of human Th2 cell responses and shapes the atopic skin microenvironment, where it could serve as a novel therapeutic target for Th2 mediated diseases. A…