Anna Witasp
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View article: Reduced mtDNA Copy Number Links to Vascular Calcification and Restores After Transplantation
Reduced mtDNA Copy Number Links to Vascular Calcification and Restores After Transplantation Open
Patients with chronic kidney disease (CKD) face an increased risk of early vascular aging, progressive vascular calcification, and premature death. With increasing age, mitochondrial function and mitochondrial DNA copy number (mtDNA-cn) de…
View article: Recurrent somatic mutation and progerin expression in early vascular aging of chronic kidney disease
Recurrent somatic mutation and progerin expression in early vascular aging of chronic kidney disease Open
Early vascular aging plays a central role in chronic kidney disease (CKD), but its molecular causes remain unclear. Somatic mutations accumulate in various cells with age, yet their functional contribution to aging tissues is not well unde…
View article: The renal response to FGF23 shifts from phosphaturia towards inflammation in kidney disease
The renal response to FGF23 shifts from phosphaturia towards inflammation in kidney disease Open
Background FGF23 excess is associated with morbidity and mortality, but the role of excessive circulating FGF23 concentrations as a mere biomarker or causative factor of pathology is controversial. Here, we investigated the consequences of…
View article: Vascular endothelial growth factor B-mediated fatty acid flux in the adipose-kidney axis contributes to lipotoxicity in diabetic kidney disease
Vascular endothelial growth factor B-mediated fatty acid flux in the adipose-kidney axis contributes to lipotoxicity in diabetic kidney disease Open
A common observation in diabetic kidney disease is lipid accumulation, but the mechanism(s) underlying this pathology is unknown. Inhibition of Vascular endothelial growth factor B (VEGF-B) signaling was shown to prevent glomerular lipid a…
View article: Early vascular aging in chronic kidney disease: focus on microvascular maintenance, senescence signature and potential therapeutics
Early vascular aging in chronic kidney disease: focus on microvascular maintenance, senescence signature and potential therapeutics Open
Chronic kidney disease (CKD) is a strong risk factor for cardiovascular mortality and morbidity. We hypothesized that a senescent phenotype instigated by uremic toxins could account for early vascular aging (EVA) and vascular dysfunctions …
View article: Defining the molecular response to ischemia-reperfusion injury and remote ischemic preconditioning in human kidney transplantation
Defining the molecular response to ischemia-reperfusion injury and remote ischemic preconditioning in human kidney transplantation Open
Background Ischemia-reperfusion injury (IRI) inevitably occurs during kidney transplantation and extended ischemia is associated with delayed graft function and poor outcomes. Remote ischemic preconditioning (RIPC) is a simple, noninvasive…
View article: Kidney transcriptomics signature of prospective rapid diabetic kidney disease progression
Kidney transcriptomics signature of prospective rapid diabetic kidney disease progression Open
Previous cross-sectional transcriptomic studies on diabetic kidney disease (DKD) kidney tissue have shown correlations between gene expression and both disease status and kidney function at time of biopsy, but longitudinal data is scarce. …
View article: #3001 MtDNA copy number correlates to coronary artery calcium score and biological age in kidney failure patients
#3001 MtDNA copy number correlates to coronary artery calcium score and biological age in kidney failure patients Open
Background and Aims Chronic kidney disease (CKD) and kidney failure are connected to increased oxidative stress and vascular calcification, which are indicators for development of comorbidities and mortality outcome. Mitochondrial (mt)DNA …
View article: #2368 GHRH levels and AhR expression in CKD patients before and after kidney transplantation
#2368 GHRH levels and AhR expression in CKD patients before and after kidney transplantation Open
Background and Aims Chronic kidney disease (CKD) is an irreversible decline in renal function where kidney transplantation (KT) is the optimal therapeutic intervention. We aim to investigate the role and activation of the uremic toxin rece…
View article: Sweet, bloody consumption – what we eat and how it affects vascular ageing, the BBB and kidney health in CKD
Sweet, bloody consumption – what we eat and how it affects vascular ageing, the BBB and kidney health in CKD Open
In today's industrialized society food consumption has changed immensely toward heightened red meat intake and use of artificial sweeteners instead of grains and vegetables or sugar, respectively. These dietary changes affect public health…
View article: Epigenetic clocks indicate that kidney transplantation and not dialysis mitigate the effects of renal ageing
Epigenetic clocks indicate that kidney transplantation and not dialysis mitigate the effects of renal ageing Open
Background Chronic kidney disease (CKD) is an age‐related disease that displays multiple features of accelerated ageing. It is currently unclear whether the two treatment options for end‐stage kidney disease (dialysis and kidney transplant…
View article: Deep learning–based segmentation and quantification of podocyte foot process morphology suggests differential patterns of foot process effacement across kidney pathologies
Deep learning–based segmentation and quantification of podocyte foot process morphology suggests differential patterns of foot process effacement across kidney pathologies Open
Morphological alterations at the kidney filtration barrier increase intrinsic capillary wall permeability resulting in albuminuria. However, automated, quantitative assessment of these morphological changes has not been possible with elect…
View article: Fibroblast growth factor 23 is independently associated with renal magnesium handling in patients with chronic kidney disease
Fibroblast growth factor 23 is independently associated with renal magnesium handling in patients with chronic kidney disease Open
Background Disturbances in magnesium homeostasis are common in patients with chronic kidney disease (CKD) and are associated with increased mortality. The kidney is a key organ in maintaining normal serum magnesium concentrations. To this …
View article: The role of dendrin in IgA nephropathy
The role of dendrin in IgA nephropathy Open
Background Immunoglobulin A nephropathy (IgAN) and its systemic variant IgA vasculitis (IgAV) damage the glomeruli, resulting in proteinuria, hematuria and kidney impairment. Dendrin is a podocyte-specific protein suggested to be involved …
View article: Osteomodulin attenuates smooth muscle cell osteogenic transition in vascular calcification
Osteomodulin attenuates smooth muscle cell osteogenic transition in vascular calcification Open
Rationale Vascular calcification is a prominent feature of late‐stage diabetes, renal and cardiovascular disease (CVD), and has been linked to adverse events. Recent studies in patients reported that plasma levels of osteomodulin (OMD), a …
View article: Longitudinal genome-wide DNA methylation changes in response to kidney failure replacement therapy
Longitudinal genome-wide DNA methylation changes in response to kidney failure replacement therapy Open
Chronic kidney disease (CKD) is an emerging public health priority associated with high mortality rates and demanding treatment regimens, including life-style changes, medications or even dialysis or renal transplantation. Unavoidably, the…
View article: Deep learning-based segmentation and quantification of podocyte foot process morphology
Deep learning-based segmentation and quantification of podocyte foot process morphology Open
The kidneys constantly filter enormous amounts of fluid, with almost complete retention of albumin and other macromolecules in the plasma. Diseases of podocytes at the kidney filtration barrier reduce the intrinsic permeability of the capi…
View article: Functional vitamin K insufficiency, vascular calcification and mortality in advanced chronic kidney disease: A cohort study
Functional vitamin K insufficiency, vascular calcification and mortality in advanced chronic kidney disease: A cohort study Open
Patients with chronic kidney disease (CKD) suffer from vitamin K deficiency and are at high risk of vascular calcification (VC) and premature death. We investigated the association of functional vitamin K deficiency with all-cause mortalit…
View article: A fast and simple clearing and swelling protocol for 3D in-situ imaging of the kidney across scales
A fast and simple clearing and swelling protocol for 3D in-situ imaging of the kidney across scales Open
In recent years, many light-microscopy protocols have been published for visualization of nanoscale structures in the kidney. These protocols present researchers with new tools to evaluate both foot process anatomy and effacement, as well …
View article: Imaging Renal Ultrastructure using a Fast and Simple Optical Clearing and Swelling Protocol
Imaging Renal Ultrastructure using a Fast and Simple Optical Clearing and Swelling Protocol Open
Many light-microscopy protocols have in recent years been published for visualization of ultrastructure in the kidney. These protocols present researchers with new tools to evaluate both foot process anatomy and effacement, as well as prot…
View article: P0669HIGH ESTIMATED PHENOTYPIC AGE ASSOCIATES WITH WORSE CLINICAL OUTCOME IN CHRONIC KIDNEY DISEASE PATIENTS
P0669HIGH ESTIMATED PHENOTYPIC AGE ASSOCIATES WITH WORSE CLINICAL OUTCOME IN CHRONIC KIDNEY DISEASE PATIENTS Open
Background and Aims Ageing represents the greatest risk factor contributing to increased morbidity and mortality in most chronic diseases; it encompasses numerous biological changes resulting in declining physiological function and increas…
View article: P0714RELATIONSHIP BETWEEN BIOLOGICAL AGE ESTIMATED BY SKIN AUTOFLUORESCENCE, CHRONOLOGICAL AGE, AND MORTALITY IN CHRONIC KIDNEY DISEASE
P0714RELATIONSHIP BETWEEN BIOLOGICAL AGE ESTIMATED BY SKIN AUTOFLUORESCENCE, CHRONOLOGICAL AGE, AND MORTALITY IN CHRONIC KIDNEY DISEASE Open
Background and Aims While chronological age associates with increased risk of death, there is a quest for markers of biological age in chronic kidney disease (CKD) that better reflect accumulation of tissue and cellular damage, which could…
View article: Novel insights into the disease transcriptome of human diabetic glomeruli and tubulointerstitium
Novel insights into the disease transcriptome of human diabetic glomeruli and tubulointerstitium Open
Background Diabetic nephropathy (DN) is the most common cause of end-stage renal disease, affecting ∼30% of the rapidly growing diabetic population, and strongly associated with cardiovascular risk. Despite this, the molecular mechanisms o…
View article: Inflammation and Premature Ageing in Chronic Kidney Disease
Inflammation and Premature Ageing in Chronic Kidney Disease Open
Persistent low-grade inflammation and premature ageing are hallmarks of the uremic phenotype and contribute to impaired health status, reduced quality of life, and premature mortality in chronic kidney disease (CKD). Because there is a hug…
View article: Reduced skeletal muscle expression of mitochondrial-derived peptides humanin and MOTS-C and Nrf2 in chronic kidney disease
Reduced skeletal muscle expression of mitochondrial-derived peptides humanin and MOTS-C and Nrf2 in chronic kidney disease Open
Advanced chronic kidney disease (CKD) is characterized by a premature aging phenotype of multifactorial origin. Mitochondrial dysfunction is prevalent in CKD and has been proposed as a major contributor to poor muscle function. Although th…
View article: Chemerin inhibits vascular calcification through ChemR23 and is associated with lower coronary calcium in chronic kidney disease
Chemerin inhibits vascular calcification through ChemR23 and is associated with lower coronary calcium in chronic kidney disease Open
Background Chemerin is an adipokine that signals through the G protein‐coupled receptor ChemR23 and is associated with inflammation, glucose homeostasis, lipid metabolism and renal function, all of which strongly influence cardiovascular r…