Anna Kryzhanivska
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View article: INTERPLAY OF EPIGENETIC REGULATION OF KI-67 AND P53 BY MIR-21 AND MIR-34A IN CERVICAL INTRAEPITHELIAL NEOPLASIA
INTERPLAY OF EPIGENETIC REGULATION OF KI-67 AND P53 BY MIR-21 AND MIR-34A IN CERVICAL INTRAEPITHELIAL NEOPLASIA Open
Background. Cervical cancer (CC), primarily linked to persistent HPV infection, arises from complex genetic and epigenetic alterations. The early detection of cervical intraepithelial neoplasia (CIN) allows for CC prevention. Recent data h…
View article: PREVENTION OF PACLITAXEL-INDUCED MOTOR NEUROPATHY OF FIBULAR AND TIBIAL NERVES WITH ALPHA-LIPOIC ACID AND IPIDACRIN HYDROCHLORIDE IN BREAST CANCER PATIENTS
PREVENTION OF PACLITAXEL-INDUCED MOTOR NEUROPATHY OF FIBULAR AND TIBIAL NERVES WITH ALPHA-LIPOIC ACID AND IPIDACRIN HYDROCHLORIDE IN BREAST CANCER PATIENTS Open
Aim. To investigate neurofunctional parameters of motor nerves in breast cancer (BCa) patients with paclitaxelinduced peripheral neuropathy (PIPN) and to determine the feasibility of using alpha-lipoic acid (ALA) in combination with ipidac…
View article: Frequency and structure of endocrine diseases in patients with endometrial cancer
Frequency and structure of endocrine diseases in patients with endometrial cancer Open
Background. Endometrial cancer (EC) is one of the most common malignant neoplasms of the female reproductive system. According to the ESGO/ESTRO/ESP guidelines, metabolic and endocrine factors are recognized as key modifiable risk factors …
View article: Impact of systemic comorbidities and diabetes mellitus on survival in head and neck cancer: a cohort study
Impact of systemic comorbidities and diabetes mellitus on survival in head and neck cancer: a cohort study Open
Background. The prognosis for patients with locally advanced head and neck cancer is often complicated by systemic comorbidities. The specific impact of metabolic disorders, particularly diabetes mellitus, on treatment outcomes remains a …
View article: Data from Novel Combinations of Immunotherapies or DNA Damage Repair Inhibitors in Platinum-Refractory Extensive-Stage Small Cell Lung Cancer: The Phase II BALTIC Study
Data from Novel Combinations of Immunotherapies or DNA Damage Repair Inhibitors in Platinum-Refractory Extensive-Stage Small Cell Lung Cancer: The Phase II BALTIC Study Open
Purpose:The phase II, multiarm, signal-searching BALTIC study (NCT02937818) assessed novel treatment combinations for platinum-refractory/resistant extensive-stage small cell lung cancer (ES-SCLC).Patients and Methods:Patients with ES-SCLC…
View article: Data from Novel Combinations of Immunotherapies or DNA Damage Repair Inhibitors in Platinum-Refractory Extensive-Stage Small Cell Lung Cancer: The Phase II BALTIC Study
Data from Novel Combinations of Immunotherapies or DNA Damage Repair Inhibitors in Platinum-Refractory Extensive-Stage Small Cell Lung Cancer: The Phase II BALTIC Study Open
Purpose:The phase II, multiarm, signal-searching BALTIC study (NCT02937818) assessed novel treatment combinations for platinum-refractory/resistant extensive-stage small cell lung cancer (ES-SCLC).Patients and Methods:Patients with ES-SCLC…
View article: Supplementary Data 1 from Novel Combinations of Immunotherapies or DNA Damage Repair Inhibitors in Platinum-Refractory Extensive-Stage Small Cell Lung Cancer: The Phase II BALTIC Study
Supplementary Data 1 from Novel Combinations of Immunotherapies or DNA Damage Repair Inhibitors in Platinum-Refractory Extensive-Stage Small Cell Lung Cancer: The Phase II BALTIC Study Open
Supplementary tables and figures
View article: Supplementary Data 1 from Novel Combinations of Immunotherapies or DNA Damage Repair Inhibitors in Platinum-Refractory Extensive-Stage Small Cell Lung Cancer: The Phase II BALTIC Study
Supplementary Data 1 from Novel Combinations of Immunotherapies or DNA Damage Repair Inhibitors in Platinum-Refractory Extensive-Stage Small Cell Lung Cancer: The Phase II BALTIC Study Open
Supplementary tables and figures
View article: Novel Combinations of Immunotherapies or DNA Damage Repair Inhibitors in Platinum-Refractory Extensive-Stage Small Cell Lung Cancer: The Phase II BALTIC Study
Novel Combinations of Immunotherapies or DNA Damage Repair Inhibitors in Platinum-Refractory Extensive-Stage Small Cell Lung Cancer: The Phase II BALTIC Study Open
Purpose: The phase II, multiarm, signal-searching BALTIC study (NCT02937818) assessed novel treatment combinations for platinum-refractory/resistant extensive-stage small cell lung cancer (ES-SCLC). Patients and Methods: Patients with ES-S…
View article: Rivoceranib, a VEGFR-2 inhibitor, monotherapy in previously treated patients with advanced or metastatic gastric or gastroesophageal junction cancer (ANGEL study): an international, randomized, placebo-controlled, phase 3 trial
Rivoceranib, a VEGFR-2 inhibitor, monotherapy in previously treated patients with advanced or metastatic gastric or gastroesophageal junction cancer (ANGEL study): an international, randomized, placebo-controlled, phase 3 trial Open
Background Rivoceranib is an oral, selective tyrosine kinase inhibitor of vascular endothelial growth factor receptor-2. ANGEL (NCT03042611) was a global, randomized, double-blinded, placebo-controlled, phase 3 study evaluating rivoceranib…
View article: IMMEDIATE AND LONG-TERM OUTCOMES OF COMPREHENSIVE TREATMENT FOR PATIENTS WITH OVARIAN CANCER STAGE III-IV
IMMEDIATE AND LONG-TERM OUTCOMES OF COMPREHENSIVE TREATMENT FOR PATIENTS WITH OVARIAN CANCER STAGE III-IV Open
Summary. Aim:to evaluate the immediate treatment outcomes and overall and relapse-free survival of patients with ovarian cancer stage III-IV depending on the treatment method. Object and methods: the study presents the overall and relapse-…
View article: FEATURES OF COL1A1 EXPRESSION IN BREAST CANCER TISSUE OF YOUNG PATIENTS
FEATURES OF COL1A1 EXPRESSION IN BREAST CANCER TISSUE OF YOUNG PATIENTS Open
Background. In the last decades, the incidence of breast cancer (BCa) in young women has been increasing steadily. The quantitative indicators of expression of collagen, which play important role in stromal microenvironment, and their asso…
View article: Role of Computed Tomography in the Diagnosis of Ovarian Cancer
Role of Computed Tomography in the Diagnosis of Ovarian Cancer Open
Introduction. Malignant formations in the ovaries remain a pressing issue in the field of oncology today. Ovarian cancer occupies one of the leading positions in terms of frequency (7th place) and mortality (4th place). The lack of symptom…
View article: Correlation of Heavy Metal Content in the Blood of Patients with Ovarian Cancer by Place of Residence
Correlation of Heavy Metal Content in the Blood of Patients with Ovarian Cancer by Place of Residence Open
Introduction. Malignant ovarian tumours are an urgent problem in oncology today. Ovarian cancer (OC) is in the top ten in terms of prevalence, ranking 7th, and in the top five in terms of mortality, ranking 4th. The asymptomatic course of …
View article: Comparison of SP263 and 22C3 immunohistochemistry PD-L1 assays for clinical efficacy of adjuvant atezolizumab in non-small cell lung cancer: results from the randomized phase III IMpower010 trial
Comparison of SP263 and 22C3 immunohistochemistry PD-L1 assays for clinical efficacy of adjuvant atezolizumab in non-small cell lung cancer: results from the randomized phase III IMpower010 trial Open
Background Tumor samples from the phase III IMpower010 study were used to compare two programmed death-ligand 1 (PD-L1) immunohistochemistry assays (VENTANA SP263 and Dako 22C3) for identification of PD-L1 patient subgroups (negative, posi…
View article: Radiological Diagnostics of Assessing Local and Distant Spread of the Tumour in Patients with Endometrial Cancer
Radiological Diagnostics of Assessing Local and Distant Spread of the Tumour in Patients with Endometrial Cancer Open
Surgical treatment is the primary approach recommended by American and European guidelines for patients with uterine cancer, with the goal of individually tailoring the surgical intervention and deciding on the necessity of lymph node diss…
View article: EFFECTIVENESS OF ALPHA-LIPOIC ACID AND IPIDACRINE HYDROCHLORIDE IN PREVENTION OF PACLITAXEL-INDUCED PERIPHERAL NEUROPATHY ASSESSED BY ELECTRONEUROMYOGRAPHY OF SUPERFICIAL PERONEAL AND SURAL NERVES
EFFECTIVENESS OF ALPHA-LIPOIC ACID AND IPIDACRINE HYDROCHLORIDE IN PREVENTION OF PACLITAXEL-INDUCED PERIPHERAL NEUROPATHY ASSESSED BY ELECTRONEUROMYOGRAPHY OF SUPERFICIAL PERONEAL AND SURAL NERVES Open
Aim: To investigate the neurofunctional parameters in breast cancer (BC) patients with paclitaxel-induced peripheral neuropathy (PIPN) and to clarify the feasibility of using alpha-lipoic acid (ALA) in combination with the acetylcholineste…
View article: INCIDENCE OF UTERINE SARCOMA IN IVANO-FRANKIVSK REGION
INCIDENCE OF UTERINE SARCOMA IN IVANO-FRANKIVSK REGION Open
Uterine sarcoma (US) is a rare disease characterized by an aggressive course and poor prognosis, accounting for 3–7% of malignant neoplasms of the uterus.
The goal. Study the incidence of uterine sarcoma in Ivano-Frankivsk region and to a…
View article: RISK FACTORS OF POSTOPERATIVE COMPLICATIONS DEVELOPMENT IN PATIENTS WITH RECTAL CANCER
RISK FACTORS OF POSTOPERATIVE COMPLICATIONS DEVELOPMENT IN PATIENTS WITH RECTAL CANCER Open
Rectal cancer remains one of the most pressing problems today. Despite the development of technologies that can stage the disease and the use of modern treatment protocols, there is no continuous linear improvement in patient survival. The…
View article: Pharmacological correction of immunometabolic disorders in patients with endometrioma along with chronic inflammatory diseases of the genital tract
Pharmacological correction of immunometabolic disorders in patients with endometrioma along with chronic inflammatory diseases of the genital tract Open
The objective: to determine the markers of the inflammatory process, development and implementation of methods for pharmacological correction of immunometabolic disorders in patients with endometrioma on the background of chronic inflammat…
View article: ENHANCING HEALTHCARE THROUGH THE DEVELOPMENT OF MANAGERIAL COMPETENCIES OF THE HEALTHCARE LEADERS
ENHANCING HEALTHCARE THROUGH THE DEVELOPMENT OF MANAGERIAL COMPETENCIES OF THE HEALTHCARE LEADERS Open
The study aims at diagnosing the managerial competencies of the medical managers as well as practical tools for their development in order to enhance healthcare in crisis and under unstable conditions. The authors suggest a methodical appr…
View article: 956 Retifanlimab (INCMGA00012) in patients with recurrent MSI-H or dMMR endometrial cancer: results from the POD1UM-101 study
956 Retifanlimab (INCMGA00012) in patients with recurrent MSI-H or dMMR endometrial cancer: results from the POD1UM-101 study Open
BackgroundManagement of patients with recurrent endometrial cancer after failure on platinum-based therapy remains a clinical challenge. Retifanlimab (INCMGA00012) is an investigational humanized immunoglobulin G4 monoclonal antibody again…
View article: SURVIVAL OF PATIENTS WITH RECTAL CANCER
SURVIVAL OF PATIENTS WITH RECTAL CANCER Open
The aim: To evaluate the early and late results of treatment of rectal cancer patients after special treatment methods with a view to indentifying optimal method of treatment in correlation with the stage of the disease. Materials and meth…
View article: CHEMOTHERAPY IN RECTAL CANCER
CHEMOTHERAPY IN RECTAL CANCER Open
The aim: To evaluate and analyze early and late results of treatment of patients with rectal cancer after chemotherapy. Materials and methods: The study is based on the results of observation of 779 patients with stage II, III and IV recta…