Annabel E. Smith
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View article: Aggregate-selective removal of pathological tau by clustering-activated degraders
Aggregate-selective removal of pathological tau by clustering-activated degraders Open
Selective degradation of pathological protein aggregates while sparing monomeric forms is of major therapeutic interest. The E3 ligase tripartite motif–containing protein 21 (TRIM21) degrades antibody-bound proteins in an assembly state–sp…
View article: The cytosolic antibody receptor TRIM21 is required for effective tau immunotherapy
The cytosolic antibody receptor TRIM21 is required for effective tau immunotherapy Open
Background Using a variety of cell and animal model systems we demonstrate that the cytosolic antibody receptor and E3 ligase TRIM21 plays a critical role in antibody‐mediated protection against tau pathology Method Experiments with organo…
View article: Cytosolic antibody receptor TRIM21 is required for effective tau immunotherapy in mouse models
Cytosolic antibody receptor TRIM21 is required for effective tau immunotherapy in mouse models Open
Aggregates of the protein tau are proposed to drive pathogenesis in neurodegenerative diseases. Tau can be targeted by using passively transferred antibodies (Abs), but the mechanisms of Ab protection are incompletely understood. In this w…