Annabell Coors
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View article: Brain Signal Variability During Rest as a Neural Mechanism Underlying Cognitive Reserve
Brain Signal Variability During Rest as a Neural Mechanism Underlying Cognitive Reserve Open
Background Resting-state brain signal variability has been found to vary with age and cognitive function. Neural flexibility has been suggested as a neural mechanism underlying cognitive reserve (CR), a construct that describes better than…
View article: Neuropathology determines whether brain systems segregation benefits cognitive performance
Neuropathology determines whether brain systems segregation benefits cognitive performance Open
The human brain is a large-scale network, containing multiple segregated, functionally specialized systems. With increasing age, these systems become less segregated, but the reasons and consequences of this age-related reorganization are …
View article: Personality as a Factor Underlying Cognitive Reserve
Personality as a Factor Underlying Cognitive Reserve Open
Background Cognitive reserve is a concept that explains why cognitive performance can be better than would be expected given the level of brain pathology. In this project, we investigated whether certain personality traits are a factor und…
View article: An EEG study of neurophysiological markers of cognitive reserve
An EEG study of neurophysiological markers of cognitive reserve Open
Background Cognitive reserve (CR) is a property of the brain trait that allows for better–than–expected cognitive performance, relative to the degree of brain change over the life course. However, the neurophysiological markers of CR requi…
View article: Detection of neurophysiological markers of cognitive reserve: an EEG study
Detection of neurophysiological markers of cognitive reserve: an EEG study Open
Background and objectives Cognitive reserve (CR) is a property of the brain that allows for better–than–expected cognitive performance relative to the degree of brain change over the course of life. However, neurophysiological markers of C…
View article: Brain reserve affects the expression of cognitive reserve networks
Brain reserve affects the expression of cognitive reserve networks Open
Cognitive reserve (CR) explains differential susceptibility of cognitive performance to neuropathology. However, as brain pathologies progress, cognitive decline occurs even in individuals with initially high CR. The interplay between the …
View article: Personality traits and cognitive reserve—High openness benefits cognition in the presence of age-related brain changes
Personality traits and cognitive reserve—High openness benefits cognition in the presence of age-related brain changes Open
View article: Regional Brain Structure Mediates Age‐Related Decline in Eye Movement Control
Regional Brain Structure Mediates Age‐Related Decline in Eye Movement Control Open
Background Eye movements (EM) are considered potential biomarkers of neurodegeneration because they are altered in patients with neurodegenerative disease, including Alzheimer’s disease (AD). Alterations in EM control have also been observ…
View article: Identification of circulating proteins associated with general cognitive function among middle-aged and older adults
Identification of circulating proteins associated with general cognitive function among middle-aged and older adults Open
Identifying circulating proteins associated with cognitive function may point to biomarkers and molecular process of cognitive impairment. Few studies have investigated the association between circulating proteins and cognitive function. W…
View article: Associations of genetic liability for Alzheimer’s disease with cognition and eye movements in a large, population-based cohort study
Associations of genetic liability for Alzheimer’s disease with cognition and eye movements in a large, population-based cohort study Open
To identify cognitive measures that may be particularly sensitive to early cognitive decline in preclinical Alzheimer’s disease (AD), we investigated the relation between genetic risk for AD and cognitive task performance in a large popula…
View article: Regional seropositivity for Borrelia burgdorferi and associated risk factors: findings from the Rhineland Study, Germany
Regional seropositivity for Borrelia burgdorferi and associated risk factors: findings from the Rhineland Study, Germany Open
Background Lyme borreliosis is the most prevalent vector-borne disease in Europe, and numbers might increase due to climate change. However, borreliosis is not notifiable in North Rhine-Westphalia (NRW), Germany. Hence, little is known abo…
View article: Processing speed, but not working memory or global cognition, is associated with pupil diameter during fixation
Processing speed, but not working memory or global cognition, is associated with pupil diameter during fixation Open
Mean pupil size during fixation has been suggested to reflect interindividual differences in working memory and fluid intelligence. However, due to small samples with limited age range (17–35 years) and suboptimal light conditions in previ…
View article: Associations of plasma neurofilament light protein levels with cognitive functions and brain structure parameters
Associations of plasma neurofilament light protein levels with cognitive functions and brain structure parameters Open
Background Neurofilament light (NfL) protein level is considered a non‐specific marker of neurodegeneration. NfL levels have been associated with established, non‐blood based neurodegenerative markers, including cognitive performance and r…
View article: Polygenic risk scores for schizophrenia are associated with oculomotor endophenotypes
Polygenic risk scores for schizophrenia are associated with oculomotor endophenotypes Open
Background Schizophrenia is a heterogeneous disorder with substantial heritability. The use of endophenotypes may help clarify its aetiology. Measures from the smooth pursuit and antisaccade eye movement tasks have been identified as endop…
View article: Strong age but weak sex effects in eye movement performance in the general adult population: Evidence from the Rhineland Study
Strong age but weak sex effects in eye movement performance in the general adult population: Evidence from the Rhineland Study Open
Assessing physiological changes that occur with healthy ageing is prerequisite for understanding pathophysiological age-related changes. Eye movements are studied as biomarkers for pathological changes because they are altered in patients …