Annalisa Berzigotti
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View article: Predicting hepatic decompensation using non-invasive tests in a contemporary multicentre cohort of patients with cACLD
Predicting hepatic decompensation using non-invasive tests in a contemporary multicentre cohort of patients with cACLD Open
Non-invasive tests (NITs) facilitate the early diagnosis and management of clinically significant portal hypertension (CSPH) in patients with compensated advanced chronic liver disease (cACLD) patients. In our contemporary cohort of cACLD …
View article: The impact of sarcopenia and frailty on decompensation in compensated cirrhosis: A systematic review
The impact of sarcopenia and frailty on decompensation in compensated cirrhosis: A systematic review Open
Background: Sarcopenia and frailty have a negative prognostic impact in patients with decompensated cirrhosis; however, the impact of these conditions on the prognosis of compensated cirrhosis is unknown. We performed a systematic review t…
View article: A comparative evaluation of two subharmonic-aided pressure estimation (SHAPE) analysis methods
A comparative evaluation of two subharmonic-aided pressure estimation (SHAPE) analysis methods Open
Pressure measurement in clinical practice is a valuable tool for diagnostic evaluation, especially in diseases such as portal hypertension. Currently, portal pressures are measured by invasive hepatic vein catheterization, posing risks to …
View article: When rapid weight loss backfires: hepatic encephalopathy from GLP-1 RA in MASH cirrhosis
When rapid weight loss backfires: hepatic encephalopathy from GLP-1 RA in MASH cirrhosis Open
View article: From the Editor’s Desk...
From the Editor’s Desk... Open
View article: Impact of First and Further Decompensation in Metabolic-Dysfunction Associated Compensated Advanced Chronic Liver Disease
Impact of First and Further Decompensation in Metabolic-Dysfunction Associated Compensated Advanced Chronic Liver Disease Open
BACKGROUND Metabolic dysfunction-associated steatotic liver disease (MASLD) currently stands as one of the foremost global health challenges, with a prevalence of 38% worldwide according to the most recent estimates [1] and with a concerni…
View article: Point-of-care ultrasound of the inferior vena cava for intravascular volume assessment during intravenous albumin infusion in patients with cirrhosis
Point-of-care ultrasound of the inferior vena cava for intravascular volume assessment during intravenous albumin infusion in patients with cirrhosis Open
Iatrogenic volume overload after albumin infusions in patients with cirrhosis is a potentially harmful side effect, but no policy for monitoring intravascular volume overload using non-invasive tools has been suggested so far. New-onset po…
View article: Invasive Candida infections in solid organ transplant recipients between 2008 and 2020
Invasive Candida infections in solid organ transplant recipients between 2008 and 2020 Open
Contemporary data on the epidemiology and outcomes of invasive candidiasis (IC) in solid organ transplant recipients (SOTr) are limited. This retrospective multicenter cohort study, nested within the Swiss Transplant Cohort Study, describe…
View article: External Validation of the Hepatic Steatosis Index for the Detection of Steatotic Liver Disease in Zambia
External Validation of the Hepatic Steatosis Index for the Detection of Steatotic Liver Disease in Zambia Open
The hepatic steatosis index (HSI) is used to detect steatotic liver disease (SLD), but its diagnostic performance in African populations is unknown. We performed an external validation of HSI among adults in Zambia. We consecutively screen…
View article: Exploring the trimethylamine pathway in advanced chronic liver disease
Exploring the trimethylamine pathway in advanced chronic liver disease Open
The trimethylamine (TMA)-trimethylamine-N-oxide (TMAO) pathway, involving gut microbiota-derived metabolites, may play a role in advanced chronic liver disease (ACLD). This study assessed TMA and TMAO levels in ACLD patients and their asso…
View article: Fibrosis Regression of Advanced Chronic Liver Disease Outlined by a Novel Histological Classification
Fibrosis Regression of Advanced Chronic Liver Disease Outlined by a Novel Histological Classification Open
In the past, advanced chronic liver disease was considered irreversible, but with better understanding and improved treatments, it is now recognized that fibrosis is a dynamic process that can regress even when it has reached the stage of …
View article: Impact of first and further decompensation in patients with compensated ACLD due to MASLD
Impact of first and further decompensation in patients with compensated ACLD due to MASLD Open
In this large international multicenter cohort of 6,061 patients with compensated advanced chronic liver disease (cACLD) due to metabolic dysfunction-associated steatotic liver disease (MASLD), we examined the clinical impact of first and …
View article: From the Editor’s Desk…
From the Editor’s Desk… Open
View article: Automated quantification of T1 and T2 relaxation times in liver mpMRI using deep learning: a sequence-adaptive approach
Automated quantification of T1 and T2 relaxation times in liver mpMRI using deep learning: a sequence-adaptive approach Open
Objectives To evaluate a deep learning sequence-adaptive liver multiparametric MRI (mpMRI) assessment with validation in different populations using total and segmental T1 and T2 relaxation time maps. Methods A neural network was trained t…
View article: Corrigendum to ‘From the Editor's Desk▪▪▪’ [J Hepatol (2025) 549-552]
Corrigendum to ‘From the Editor's Desk▪▪▪’ [J Hepatol (2025) 549-552] Open
View article: From the Editor’s Desk...
From the Editor’s Desk... Open
View article: EASL Clinical Practice Guidelines on extrahepatic abdominal surgery in patients with cirrhosis and advanced chronic liver disease
EASL Clinical Practice Guidelines on extrahepatic abdominal surgery in patients with cirrhosis and advanced chronic liver disease Open
View article: Integrated targeted deep sequencing reveals unique tissue-of-origin and donor-derived cell-free DNA signatures in organ transplant recipients
Integrated targeted deep sequencing reveals unique tissue-of-origin and donor-derived cell-free DNA signatures in organ transplant recipients Open
Solid organ transplantation is currently the best option to treat end-stage organ disease. However, it requires lifelong immunosuppressive therapy in most cases, and the diagnosis of rejection and other types of graft injury requires invas…
View article: Transjugular diagnostic procedures in hepatology: Indications, techniques and interpretation
Transjugular diagnostic procedures in hepatology: Indications, techniques and interpretation Open
Measurement of the hepatic venous pressure gradient (HVPG) and transjugular liver biopsy have emerged as important tools in clinical hepatology. Measurement of HVPG is considered the gold standard for detecting clinically significant porta…
View article: Surgical Site Infections, Risk Factors, and Outcomes After Liver Transplant
Surgical Site Infections, Risk Factors, and Outcomes After Liver Transplant Open
Importance Surgical site infections (SSIs) are one of the most common health care–associated infections. Surgical site infections can have harmful effects in liver transplant (LT) recipients. Objective To assess the incidence of SSI after …
View article: The Association of Heart Failure and Liver T1 Mapping in Cardiac Magnetic Resonance Imaging
The Association of Heart Failure and Liver T1 Mapping in Cardiac Magnetic Resonance Imaging Open
Background/Objectives: The objective of this study was to investigate the association between congestive heart failure (CHF) and T1 mapping in both liver lobes using cardiac MRI. Methods: This retrospective study included patients who unde…
View article: Association of MRI-derived Segmental Nonfunctional Liver Volume and Chronic Liver Disease
Association of MRI-derived Segmental Nonfunctional Liver Volume and Chronic Liver Disease Open
To determine whether the nonfunctional liver volume (NFLV) is an indicator of chronic liver disease (CLD). Multiparametric 3T abdominal MRI examinations enhanced with gadobenate dimeglumine of 51 patients were included in the study and div…
View article: Optimizing non-invasive monitoring of the therapeutic response to NSBBs in portal hypertension: is machine learning the answer?
Optimizing non-invasive monitoring of the therapeutic response to NSBBs in portal hypertension: is machine learning the answer? Open
View article: FIB-4 predicts events in compensated advanced chronic liver disease and type 2 diabetes treated with GLP-1-receptor-agonists
FIB-4 predicts events in compensated advanced chronic liver disease and type 2 diabetes treated with GLP-1-receptor-agonists Open
FIB-4 is a strong prognostic tool to screen patients and refer them to specialists, in cACLD patients and pharmacologically treated type 2 diabetes, irrespective of treatment.
View article: Estimating the prevalence of adults at risk for advanced hepatic fibrosis using FIB-4 in a Swiss tertiary care hospital
Estimating the prevalence of adults at risk for advanced hepatic fibrosis using FIB-4 in a Swiss tertiary care hospital Open
Background & aims Chronic liver diseases pose a serious public health issue. Identifying patients at risk for advanced liver fibrosis is crucial for early intervention. The Fibrosis-4 score (FIB-4), a simple non-invasive test, classifies p…
View article: Non-invasive assessment of portal hypertension: Liver stiffness and beyond
Non-invasive assessment of portal hypertension: Liver stiffness and beyond Open
Portal hypertension (PH) leads to life-threatening clinical manifestations such as bleeding from gastro-oesophageal varices, ascites and its complications, and portosystemic encephalopathy. It can develop because of advanced chronic liver …
View article: Recipient‐Donor Sex Constellation in Liver Transplantation for Hepatocellular Carcinoma—An <scp>ELTR</scp> Study
Recipient‐Donor Sex Constellation in Liver Transplantation for Hepatocellular Carcinoma—An <span>ELTR</span> Study Open
Background & Aims Hepatocellular carcinoma (HCC) is the third leading cause of cancer‐related death worldwide. Liver transplantation (LT) is a curative treatment option. We investigated survival outcomes based on recipient‐donor sex conste…
View article: Reintegration Into the Workforce After Kidney Transplantation Based on Urbanization Status in Switzerland
Reintegration Into the Workforce After Kidney Transplantation Based on Urbanization Status in Switzerland Open
View article: Inter‐Reader Agreement for Contrast‐Enhanced Ultrasound Liver Imaging Reporting and Data System Major Features and Final Categorization
Inter‐Reader Agreement for Contrast‐Enhanced Ultrasound Liver Imaging Reporting and Data System Major Features and Final Categorization Open
Objectives Contrast‐enhanced ultrasound (CEUS) Liver Imaging Reporting and Data System (LI‐RADS) is used to definitively diagnose hepatocellular carcinoma (HCC) in patients at risk. However, the user variability associated with CEUS LI‐RAD…
View article: Combining CEUS and CT/MRI LI-RADS major imaging features: diagnostic accuracy for classification of indeterminate liver observations in patients at risk for HCC
Combining CEUS and CT/MRI LI-RADS major imaging features: diagnostic accuracy for classification of indeterminate liver observations in patients at risk for HCC Open
Purpose To determine the diagnostic accuracy of combining CEUS and CT/MRI LI-RADS major imaging features for the improved categorization of liver observations indeterminate on both CT/MRI and CEUS. Materials and methods A retrospective ana…