Annarita Barone
YOU?
Author Swipe
View article: Molecular Underpinning of Treatment-Resistant Schizophrenia: A Putative Different Neurobiology from Treatment-Responsive Schizophrenia
Molecular Underpinning of Treatment-Resistant Schizophrenia: A Putative Different Neurobiology from Treatment-Responsive Schizophrenia Open
Treatment-resistant schizophrenia (TRS) affects up to one in three individuals with schizophrenia and is associated with a significant clinical, social, and economic burden. Different from treatment-responsive forms, TRS appears to involve…
View article: 493. A NOVEL GRAPH THEORY-DRIVEN APPLICATION OF 18F-FDG-PET WITH ANTIPSYCHOTIC DOSE CORRECTION AND A MACHINE LEARNING APPROACH TO CAPTURE DISCRETE BRAIN METABOLIC CONNECTIVITY IN TREATMENT-RESISTANT SCHIZOPHRENIA
493. A NOVEL GRAPH THEORY-DRIVEN APPLICATION OF 18F-FDG-PET WITH ANTIPSYCHOTIC DOSE CORRECTION AND A MACHINE LEARNING APPROACH TO CAPTURE DISCRETE BRAIN METABOLIC CONNECTIVITY IN TREATMENT-RESISTANT SCHIZOPHRENIA Open
Background Approximately one-third of patients diagnosed with schizophrenia do not respond to at least two antipsychotic medications administered at adequate doses and duration, and are thus considered treatment-resistant1. Dysfunction in …
View article: 422. ORGANIZING THE DISORGANIZATION: AN ARTIFICIAL INTELLIGENCE-BASED DECISION SUPPORTING SYSTEM FOR THE DETECTION OF DISORGANIZATION SYMPTOMS IN SCHIZOPHRENIA AND NON-AFFECTED PARTICIPANTS
422. ORGANIZING THE DISORGANIZATION: AN ARTIFICIAL INTELLIGENCE-BASED DECISION SUPPORTING SYSTEM FOR THE DETECTION OF DISORGANIZATION SYMPTOMS IN SCHIZOPHRENIA AND NON-AFFECTED PARTICIPANTS Open
Background Disorganization symptoms are a core feature of schizophrenia, encompassing cognitive, affective, and behavioral manifestations such as formal thought and language disorders (FTD), motor disorganization, and inappropriate affect.…
View article: In vivo assessment of GABAergic inhibition and glutamate facilitation in treatment-resistant schizophrenia: a TMS study integrating clinical, cognitive, and neurophysiological evaluations
In vivo assessment of GABAergic inhibition and glutamate facilitation in treatment-resistant schizophrenia: a TMS study integrating clinical, cognitive, and neurophysiological evaluations Open
Treatment-resistant schizophrenia (TRS) affects approximately one-third of individuals with schizophrenia, posing significant challenges for clinical management. Clozapine treatment is often delayed, underscoring the urgent need for an ear…
View article: The Role of Astrocytes in the Molecular Pathophysiology of Schizophrenia: Between Neurodevelopment and Neurodegeneration
The Role of Astrocytes in the Molecular Pathophysiology of Schizophrenia: Between Neurodevelopment and Neurodegeneration Open
Schizophrenia is a chronic and severe psychiatric disorder affecting approximately 1% of the global population, characterized by disrupted synaptic plasticity and brain connectivity. While substantial evidence supports its classification a…
View article: Corpus Callosum Volume in Treatment-Resistant compared to Treatment Responsive Schizophrenia patients with and without cannabis use disorder: a Novel Artificial Intelligence Method Applied to Single-Subject Magnetic Resonance Imaging
Corpus Callosum Volume in Treatment-Resistant compared to Treatment Responsive Schizophrenia patients with and without cannabis use disorder: a Novel Artificial Intelligence Method Applied to Single-Subject Magnetic Resonance Imaging Open
Introduction The corpus callosum (CC) is essential for interhemispheric communication, and its abnormal integration is central to the neurobiology of schizophrenia (SCZ). SCZ patients have a 10-fold higher risk of cannabis use disorder (CU…
View article: HOMER 1A MODULATION IN A RODENT MODEL OF PERINATAL STRESS: TRANSLATIONAL INFERENCE FROM POSTSYNAPTIC DENSITY IMMEDIATE-EARLY GENE-BASED NETWORK ANALYSES. IMPLICATION FOR NEURODEVELOPMENTAL DISORDERS
HOMER 1A MODULATION IN A RODENT MODEL OF PERINATAL STRESS: TRANSLATIONAL INFERENCE FROM POSTSYNAPTIC DENSITY IMMEDIATE-EARLY GENE-BASED NETWORK ANALYSES. IMPLICATION FOR NEURODEVELOPMENTAL DISORDERS Open
Background Stress is responsible for impacting brain regions’ synaptic changes and functional connectivity modifications that hesitate in several cognitive processes such as spatial and declarative memory, fear, and memories of emotionally…
View article: ALTERED FUNCTIONAL CONNECTIVITY OF FUSIFORM GYRUS AND DISORGANIZATION DOMAIN AS CORE CORRELATES OF TREATMENT- RESISTANT SCHIZOPHRENIA: A RESTING-STATE FMRI STUDY
ALTERED FUNCTIONAL CONNECTIVITY OF FUSIFORM GYRUS AND DISORGANIZATION DOMAIN AS CORE CORRELATES OF TREATMENT- RESISTANT SCHIZOPHRENIA: A RESTING-STATE FMRI STUDY Open
Background The neurobiology underlying treatment-resistant schizophrenia (TRS) has not been fully elucidated1. This project provides a preliminary dissection of the neurobiological underpinnings of cognitive dysfunction in schizophrenia (S…
View article: Addressing brain metabolic connectivity in treatment-resistant schizophrenia: a novel graph theory-driven application of 18F-FDG-PET with antipsychotic dose correction
Addressing brain metabolic connectivity in treatment-resistant schizophrenia: a novel graph theory-driven application of 18F-FDG-PET with antipsychotic dose correction Open
Few studies using Positron Emission Tomography with 18 F-fluorodeoxyglucose ( 18 F-FDG-PET) have examined the neurobiological basis of antipsychotic resistance in schizophrenia, primarily focusing on metabolic activity, with none investiga…
View article: Sex differences in deep brain shape and asymmetry persist across schizophrenia and healthy individuals: A meta-analysis from the ENIGMA-Schizophrenia Working Group
Sex differences in deep brain shape and asymmetry persist across schizophrenia and healthy individuals: A meta-analysis from the ENIGMA-Schizophrenia Working Group Open
Background Schizophrenia (SCZ) is characterized by a disconnect from reality that manifests as various clinical and cognitive symptoms, and persistent neurobiological abnormalities. Sex-related differences in clinical presentation imply se…
View article: Neurostructural subgroup in 4291 individuals with schizophrenia identified using the subtype and stage inference algorithm
Neurostructural subgroup in 4291 individuals with schizophrenia identified using the subtype and stage inference algorithm Open
Machine learning can be used to define subtypes of psychiatric conditions based on shared biological foundations of mental disorders. Here we analyzed cross-sectional brain images from 4,222 individuals with schizophrenia and 7038 healthy …
View article: Perinatal stress modulates glutamatergic functional connectivity: A post-synaptic density immediate early gene-based network analysis
Perinatal stress modulates glutamatergic functional connectivity: A post-synaptic density immediate early gene-based network analysis Open
View article: Structural brain abnormalities and aggressive behaviour in schizophrenia: Mega-analysis of data from 2095 patients and 2861 healthy controls via the ENIGMA consortium
Structural brain abnormalities and aggressive behaviour in schizophrenia: Mega-analysis of data from 2095 patients and 2861 healthy controls via the ENIGMA consortium Open
Background Schizophrenia is associated with an increased risk of aggressive behaviour, which may partly be explained by illness-related changes in brain structure. However, previous studies have been limited by group-level analyses, small …
View article: Vein wall thickness and severity of pulmonary involvement due to sars n-cov2 virus infection
Vein wall thickness and severity of pulmonary involvement due to sars n-cov2 virus infection Open
View article: Network analysis on Homer1a-expression in schizophrenia animal model and synaptic modulation by dopamine D2R antagonist
Network analysis on Homer1a-expression in schizophrenia animal model and synaptic modulation by dopamine D2R antagonist Open
View article: Assessment of motor cortex excitability and plasticity in treatment-resistant and treatment-responsive schizophrenia patients: preliminary findings
Assessment of motor cortex excitability and plasticity in treatment-resistant and treatment-responsive schizophrenia patients: preliminary findings Open
View article: Two neurostructural subtypes: results of machine learning on brain images from 4,291 individuals with schizophrenia
Two neurostructural subtypes: results of machine learning on brain images from 4,291 individuals with schizophrenia Open
Machine learning can be used to define subtypes of psychiatric conditions based on shared clinical and biological foundations, presenting a crucial step toward establishing biologically based subtypes of mental disorders. With the goal of …
View article: Estimating multimodal brain variability in schizophrenia spectrum disorders: A worldwide ENIGMA study
Estimating multimodal brain variability in schizophrenia spectrum disorders: A worldwide ENIGMA study Open
Objective Schizophrenia is a multifaceted disorder associated with structural brain heterogeneity. Despite its relevance for identifying illness subtypes and informative biomarkers, structural brain heterogeneity in schizophrenia remains i…
View article: The Neurobiological Underpinnings of Obsessive-Compulsive Symptoms in Psychosis, Translational Issues for Treatment-Resistant Schizophrenia
The Neurobiological Underpinnings of Obsessive-Compulsive Symptoms in Psychosis, Translational Issues for Treatment-Resistant Schizophrenia Open
Almost 25% of schizophrenia patients suffer from obsessive-compulsive symptoms (OCS) considered a transdiagnostic clinical continuum. The presence of symptoms pertaining to both schizophrenia and obsessive-compulsive disorder (OCD) may com…
View article: Insulin effects on core neurotransmitter pathways involved in schizophrenia neurobiology: a meta-analysis of preclinical studies. Implications for the treatment
Insulin effects on core neurotransmitter pathways involved in schizophrenia neurobiology: a meta-analysis of preclinical studies. Implications for the treatment Open
Impairment of insulin action and metabolic dysregulation have traditionally been associated with schizophrenia, although the molecular basis of such association remains still elusive. The present meta-analysis aims to assess the impact of …
View article: Schizophrenia Synaptic Pathology and Antipsychotic Treatment in the Framework of Oxidative and Mitochondrial Dysfunction: Translational Highlights for the Clinics and Treatment
Schizophrenia Synaptic Pathology and Antipsychotic Treatment in the Framework of Oxidative and Mitochondrial Dysfunction: Translational Highlights for the Clinics and Treatment Open
Schizophrenia is a worldwide mental illness characterized by alterations at dopaminergic and glutamatergic synapses resulting in global dysconnectivity within and between brain networks. Impairments in inflammatory processes, mitochondrial…
View article: Canonical and Non-Canonical Antipsychotics’ Dopamine-Related Mechanisms of Present and Next Generation Molecules: A Systematic Review on Translational Highlights for Treatment Response and Treatment-Resistant Schizophrenia
Canonical and Non-Canonical Antipsychotics’ Dopamine-Related Mechanisms of Present and Next Generation Molecules: A Systematic Review on Translational Highlights for Treatment Response and Treatment-Resistant Schizophrenia Open
Schizophrenia is a severe psychiatric illness affecting almost 25 million people worldwide and is conceptualized as a disorder of synaptic plasticity and brain connectivity. Antipsychotics are the primary pharmacological treatment after mo…
View article: Dopamine Dynamics and Neurobiology of Non-Response to Antipsychotics, Relevance for Treatment Resistant Schizophrenia: A Systematic Review and Critical Appraisal
Dopamine Dynamics and Neurobiology of Non-Response to Antipsychotics, Relevance for Treatment Resistant Schizophrenia: A Systematic Review and Critical Appraisal Open
Treatment resistant schizophrenia (TRS) is characterized by a lack of, or suboptimal response to, antipsychotic agents. The biological underpinnings of this clinical condition are still scarcely understood. Since all antipsychotics block d…
View article: Neural substrates of verbal memory impairment in schizophrenia: A multimodal connectomics study
Neural substrates of verbal memory impairment in schizophrenia: A multimodal connectomics study Open
While verbal memory is among the most compromised cognitive domains in schizophrenia (SZ), its neural substrates remain elusive. Here, we explored the structural and functional brain network correlates of verbal memory impairment in SZ. We…
View article: Schizophrenia synaptic pathology and antipsychotic treatment in the framework of oxidative and mitochondrial dysfunction: translational highlights for the clinics and treatment
Schizophrenia synaptic pathology and antipsychotic treatment in the framework of oxidative and mitochondrial dysfunction: translational highlights for the clinics and treatment Open
The present systematic review aims
View article: Dopamine dynamics and neurobiology of non-response to antipsychotics, relevance for Treatment Resistant Schizophrenia. A systematic review and critical appraisal
Dopamine dynamics and neurobiology of non-response to antipsychotics, relevance for Treatment Resistant Schizophrenia. A systematic review and critical appraisal Open
The aims of this review are: i) to recapitulate and critically apprise relevant literature on dopamine-related mechanisms of TRS; ii) to discuss the methodological limitations of the studies so far conducted and delineate a theoretical fra…
View article: A Postsynaptic Density Immediate Early Gene-Based Connectome Analysis of Acute NMDAR Blockade and Reversal Effect of Antipsychotic Administration
A Postsynaptic Density Immediate Early Gene-Based Connectome Analysis of Acute NMDAR Blockade and Reversal Effect of Antipsychotic Administration Open
Although antipsychotics’ mechanisms of action have been thoroughly investigated, they have not been fully elucidated at the network level. We tested the hypothesis that acute pre-treatment with ketamine (KET) and administration of asenapin…
View article: Dysregulated Signaling at Postsynaptic Density: A Systematic Review and Translational Appraisal for the Pathophysiology, Clinics, and Antipsychotics’ Treatment of Schizophrenia
Dysregulated Signaling at Postsynaptic Density: A Systematic Review and Translational Appraisal for the Pathophysiology, Clinics, and Antipsychotics’ Treatment of Schizophrenia Open
Emerging evidence from genomics, post-mortem, and preclinical studies point to a potential dysregulation of molecular signaling at postsynaptic density (PSD) in schizophrenia pathophysiology. The PSD that identifies the archetypal asymmetr…
View article: Canonical and non-canonical antipsychotics’ molecular effects of present and next generation molecules on dopamine: translational highlights for treatment response and treatment-resistant schizophrenia
Canonical and non-canonical antipsychotics’ molecular effects of present and next generation molecules on dopamine: translational highlights for treatment response and treatment-resistant schizophrenia Open
Review question / Objective: We aimed to provide a critical appraisal of canonical and non-canonical antipsychotics' molecular effects of present and next generation m o l e c u l e s b y f o c u s i n g o n c l i n i c a l implications fo…
View article: Antipsychotics-Induced Changes in Synaptic Architecture and Functional Connectivity: Translational Implications for Treatment Response and Resistance
Antipsychotics-Induced Changes in Synaptic Architecture and Functional Connectivity: Translational Implications for Treatment Response and Resistance Open
Schizophrenia is a severe mental illness characterized by alterations in processes that regulate both synaptic plasticity and functional connectivity between brain regions. Antipsychotics are the cornerstone of schizophrenia pharmacologica…