Katie Bentley
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View article: Temporal dynamics of angiogenesis: the emerging role of mechanoregulated pathways
Temporal dynamics of angiogenesis: the emerging role of mechanoregulated pathways Open
Controlling the formation of new blood vessels, i.e. angiogenesis, is a critical challenge for the success of regenerative medicine. The development of effective strategies is hindered by our incomplete understanding of the dynamic mechani…
View article: YAP/TAZ drives Notch and angiogenesis mechanoregulation in silico
YAP/TAZ drives Notch and angiogenesis mechanoregulation in silico Open
Endothelial cells are key players in the cardiovascular system. Among other things, they are responsible for sprouting angiogenesis, the process of new blood vessel formation essential for both health and disease. Endothelial cells are str…
View article: De novo design of high-affinity protein binders with AlphaProteo
De novo design of high-affinity protein binders with AlphaProteo Open
Computational design of protein-binding proteins is a fundamental capability with broad utility in biomedical research and biotechnology. Recent methods have made strides against some target proteins, but on-demand creation of high-affinit…
View article: GPR126 is a specifier of blood-brain barrier formation in the mouse central nervous system
GPR126 is a specifier of blood-brain barrier formation in the mouse central nervous system Open
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View article: Bmp9 regulates Notch signaling and the temporal dynamics of angiogenesis via Lunatic Fringe
Bmp9 regulates Notch signaling and the temporal dynamics of angiogenesis via Lunatic Fringe Open
Summary In brief The mechanisms regulating the signaling pathways involved in angiogenesis are not fully known. Ristori et al. show that Lunatic Fringe (LFng) mediates the crosstalk between Bone Morphogenic Protein 9 (Bmp9) and Notch signa…
View article: Dual role of brain endothelial Gpr126 in blood-brain barrier development and ischemic stroke
Dual role of brain endothelial Gpr126 in blood-brain barrier development and ischemic stroke Open
The blood–brain barrier (BBB) acquires unique properties for regulation of the neuronal function during development. The genesis of the BBB coupled with angiogenesis is orchestrated by the Wnt/β-catenin signaling pathway. Aside from the im…
View article: Author response: Notch controls the cell cycle to define leader versus follower identities during collective cell migration
Author response: Notch controls the cell cycle to define leader versus follower identities during collective cell migration Open
Article Figures and data Abstract Editor's evaluation Introduction Results Discussion Materials and methods Appendix 1 Data availability References Decision letter Author response Article and author information Metrics Abstract Coordinatio…
View article: OpenABM-Covid19—An agent-based model for non-pharmaceutical interventions against COVID-19 including contact tracing
OpenABM-Covid19—An agent-based model for non-pharmaceutical interventions against COVID-19 including contact tracing Open
SARS-CoV-2 has spread across the world, causing high mortality and unprecedented restrictions on social and economic activity. Policymakers are assessing how best to navigate through the ongoing epidemic, with computational models being us…
View article: Notch controls the cell cycle to define leader versus follower identities during collective cell migration
Notch controls the cell cycle to define leader versus follower identities during collective cell migration Open
SUMMARY Coordination of cell proliferation and migration is fundamental for life, and its dysregulation has catastrophic consequences, as cancer. How cell cycle progression affects migration, and vice-versa, remains largely unknown. We add…
View article: Active perception during angiogenesis: filopodia speed up Notch selection of tip cells <i> in silico <i>and</i> in vivo </i>
Active perception during angiogenesis: filopodia speed up Notch selection of tip cells <i> in silico <i>and</i> in vivo </i> Open
How do cells make efficient collective decisions during tissue morphogenesis? Humans and other organisms use feedback between movement and sensing known as ‘sensorimotor coordination’ or ‘active perception’ to inform behaviour, but active …
View article: Active Perception during Angiogenesis: Filopodia speed up Notch selection of tip cells<i>in silico</i>and<i>in vivo</i>
Active Perception during Angiogenesis: Filopodia speed up Notch selection of tip cells<i>in silico</i>and<i>in vivo</i> Open
How do cells make efficient collective decisions during tissue morphogenesis? Humans and other organisms utilize feedback between movement and sensing known as ‘sensorimotor coordination’ or ‘active perception’ to inform behaviour, but act…
View article: Blocking endothelial apoptosis revascularizes the retina in a model of ischemic retinopathy
Blocking endothelial apoptosis revascularizes the retina in a model of ischemic retinopathy Open
Aberrant, neovascular retinal blood vessel growth is a vision-threatening complication in ischemic retinal diseases. It is driven by retinal hypoxia frequently caused by capillary nonperfusion and endothelial cell (EC) loss. We investigate…
View article: Mouse retinal cell behaviour in space and time using light sheet fluorescence microscopy
Mouse retinal cell behaviour in space and time using light sheet fluorescence microscopy Open
As the general population ages, more people are affected by eye diseases, such as retinopathies. It is therefore critical to improve imaging of eye disease mouse models. Here, we demonstrate that 1) rapid, quantitative 3D and 4D (time laps…
View article: Author response: Mouse retinal cell behaviour in space and time using light sheet fluorescence microscopy
Author response: Mouse retinal cell behaviour in space and time using light sheet fluorescence microscopy Open
Article Figures and data Abstract eLife digest Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract As the general population age…
View article: Supplementary material from "Active perception during angiogenesis: filopodia speed up Notch selection of tip cells <i>in silico and in vivo</i>"
Supplementary material from "Active perception during angiogenesis: filopodia speed up Notch selection of tip cells <i>in silico and in vivo</i>" Open
How do cells make efficient collective decisions during tissue morphogenesis? Humans and other organisms use feedback between movement and sensing known as ‘sensorimotor coordination’ or ‘active perception’ to inform behaviour, but active …
View article: Mouse retinal cell behaviour in space and time using light sheet fluorescence microscopy
Mouse retinal cell behaviour in space and time using light sheet fluorescence microscopy Open
As the general population ages and the incidence of diabetes increases epidemically, more people are affected by eye diseases, such as retinopathies. It is therefore critical to improve imaging of eye disease mouse models. Here, we demonst…
View article: Positive Feedback Defines the Timing, Magnitude, and Robustness of Angiogenesis
Positive Feedback Defines the Timing, Magnitude, and Robustness of Angiogenesis Open
Angiogenesis is driven by the coordinated collective branching of specialized leading "tip" and trailing "stalk" endothelial cells (ECs). While Notch-regulated negative feedback suppresses excessive tip selection, roles for positive feedba…
View article: NOTCH1 signaling induces pathological vascular permeability in diabetic retinopathy
NOTCH1 signaling induces pathological vascular permeability in diabetic retinopathy Open
Significance Diabetic retinopathy is a major cause of blindness in the working population. The most common cause of visual impairment in diabetic patients is diabetic macular edema (DME). Roughly 40% of patients with DME respond poorly to …
View article: Positive-feedback defines the timing and robustness of angiogenesis
Positive-feedback defines the timing and robustness of angiogenesis Open
SUMMARY Blood vessel formation by angiogenesis is critical for tissue development, homeostasis and repair, and is frequently dysregulated in disease[1–3]. Angiogenesis is triggered by vascular endothelial growth factor receptor-2/3 (VEGFR)…
View article: The temporal basis of angiogenesis
The temporal basis of angiogenesis Open
The process of new blood vessel growth (angiogenesis) is highly dynamic, involving complex coordination of multiple cell types. Though the process must carefully unfold over time to generate functional, well-adapted branching networks, we …
View article: Supplementary material from "The temporal basis of angiogenesis"
Supplementary material from "The temporal basis of angiogenesis" Open
The process of new blood vessel growth (angiogenesis) is highly dynamic, involving complex coordination of multiple cell types. Though the process must carefully unfold over time to generate functional,well-adapted branching networks, we s…
View article: Time to Decide? Dynamical Analysis Predicts Partial Tip/Stalk Patterning States Arise during Angiogenesis
Time to Decide? Dynamical Analysis Predicts Partial Tip/Stalk Patterning States Arise during Angiogenesis Open
Angiogenesis is a highly dynamic morphogenesis process; however, surprisingly little is known about the timing of the different molecular processes involved. Although the role of the VEGF-notch-DLL4 signaling pathway has been established a…
View article: Synchronization of endothelial Dll4-Notch dynamics switch blood vessels from branching to expansion
Synchronization of endothelial Dll4-Notch dynamics switch blood vessels from branching to expansion Open
Formation of a regularly branched blood vessel network is crucial in development and physiology. Here we show that the expression of the Notch ligand Dll4 fluctuates in individual endothelial cells within sprouting vessels in the mouse ret…
View article: Author response: Synchronization of endothelial Dll4-Notch dynamics switch blood vessels from branching to expansion
Author response: Synchronization of endothelial Dll4-Notch dynamics switch blood vessels from branching to expansion Open
Full text Figures and data Side by side Abstract eLife digest Introduction Results Discussion Materials and methods References Decision letter Author response Article and author information Metrics Abstract Formation of a regularly branche…