Anne Bourdoncle
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View article: Supplementary Figure S1 from RNA Interference Using <i>c-Myc</i>–Conjugated Nanoparticles Suppresses Breast and Colorectal Cancer Models
Supplementary Figure S1 from RNA Interference Using <i>c-Myc</i>–Conjugated Nanoparticles Suppresses Breast and Colorectal Cancer Models Open
Supplementary Figure S1: TEM, size and zeta potential analysis of the nanoparticles
View article: Data from RNA Interference Using <i>c-Myc</i>–Conjugated Nanoparticles Suppresses Breast and Colorectal Cancer Models
Data from RNA Interference Using <i>c-Myc</i>–Conjugated Nanoparticles Suppresses Breast and Colorectal Cancer Models Open
In this article, we report the development and preclinical validation of combinatorial therapy for treatment of cancers using RNA interference (RNAi). RNAi technology is an attractive approach to silence genes responsible for disease onset…
View article: Supplementary Figure S1 from RNA Interference Using <i>c-Myc</i>–Conjugated Nanoparticles Suppresses Breast and Colorectal Cancer Models
Supplementary Figure S1 from RNA Interference Using <i>c-Myc</i>–Conjugated Nanoparticles Suppresses Breast and Colorectal Cancer Models Open
Supplementary Figure S1: TEM, size and zeta potential analysis of the nanoparticles
View article: Supplementary Figure S3 from RNA Interference Using <i>c-Myc</i>–Conjugated Nanoparticles Suppresses Breast and Colorectal Cancer Models
Supplementary Figure S3 from RNA Interference Using <i>c-Myc</i>–Conjugated Nanoparticles Suppresses Breast and Colorectal Cancer Models Open
Supplementary Figure S3: Toxicity studies of the nanoparticle in different organs.
View article: Supplementary Table S2 from RNA Interference Using <i>c-Myc</i>–Conjugated Nanoparticles Suppresses Breast and Colorectal Cancer Models
Supplementary Table S2 from RNA Interference Using <i>c-Myc</i>–Conjugated Nanoparticles Suppresses Breast and Colorectal Cancer Models Open
Supplementary Table S2: Primers used for genotyping of mouse models. Forward and Reverse primers used for genotyping Apf fl/fl and Brca2/p53 mice during the breeding program
View article: Supplementary Legends from RNA Interference Using <i>c-Myc</i>–Conjugated Nanoparticles Suppresses Breast and Colorectal Cancer Models
Supplementary Legends from RNA Interference Using <i>c-Myc</i>–Conjugated Nanoparticles Suppresses Breast and Colorectal Cancer Models Open
Supplementary tables Table S1 & Table S2 and legends for supplementary figures
View article: Supplementary Figure S2: Cytotoxicity assays on different cell lines from RNA Interference Using <i>c-Myc</i>–Conjugated Nanoparticles Suppresses Breast and Colorectal Cancer Models
Supplementary Figure S2: Cytotoxicity assays on different cell lines from RNA Interference Using <i>c-Myc</i>–Conjugated Nanoparticles Suppresses Breast and Colorectal Cancer Models Open
Supplementary Figure S2: Cytotoxicity assays on different cell lines. In vitro cytotoxicity assay
View article: Supplementary Figure S5 from RNA Interference Using <i>c-Myc</i>–Conjugated Nanoparticles Suppresses Breast and Colorectal Cancer Models
Supplementary Figure S5 from RNA Interference Using <i>c-Myc</i>–Conjugated Nanoparticles Suppresses Breast and Colorectal Cancer Models Open
Supplementary Figure S5: Biodistribution analysis of nanoparticles using MRI and confocal and live imaging in mammary models
View article: Supplementary Table S2 from RNA Interference Using <i>c-Myc</i>–Conjugated Nanoparticles Suppresses Breast and Colorectal Cancer Models
Supplementary Table S2 from RNA Interference Using <i>c-Myc</i>–Conjugated Nanoparticles Suppresses Breast and Colorectal Cancer Models Open
Supplementary Table S2: Primers used for genotyping of mouse models. Forward and Reverse primers used for genotyping Apf fl/fl and Brca2/p53 mice during the breeding program
View article: Supplementary Figure S4 from RNA Interference Using <i>c-Myc</i>–Conjugated Nanoparticles Suppresses Breast and Colorectal Cancer Models
Supplementary Figure S4 from RNA Interference Using <i>c-Myc</i>–Conjugated Nanoparticles Suppresses Breast and Colorectal Cancer Models Open
Supplementary Figure S4: Immunoblot analysis of oncoprotein targets using knockdown and mimic probes of microRNAs
View article: Supplementary Figure S6 from RNA Interference Using <i>c-Myc</i>–Conjugated Nanoparticles Suppresses Breast and Colorectal Cancer Models
Supplementary Figure S6 from RNA Interference Using <i>c-Myc</i>–Conjugated Nanoparticles Suppresses Breast and Colorectal Cancer Models Open
Supplementary Figure S6: Densitometric analysis of immunoblots from Figure 2, Figure 3E and Figure 4C.
View article: Supplementary Figure S3 from RNA Interference Using <i>c-Myc</i>–Conjugated Nanoparticles Suppresses Breast and Colorectal Cancer Models
Supplementary Figure S3 from RNA Interference Using <i>c-Myc</i>–Conjugated Nanoparticles Suppresses Breast and Colorectal Cancer Models Open
Supplementary Figure S3: Toxicity studies of the nanoparticle in different organs.
View article: Supplementary Legends from RNA Interference Using <i>c-Myc</i>–Conjugated Nanoparticles Suppresses Breast and Colorectal Cancer Models
Supplementary Legends from RNA Interference Using <i>c-Myc</i>–Conjugated Nanoparticles Suppresses Breast and Colorectal Cancer Models Open
Supplementary tables Table S1 & Table S2 and legends for supplementary figures
View article: Supplementary Figure S5 from RNA Interference Using <i>c-Myc</i>–Conjugated Nanoparticles Suppresses Breast and Colorectal Cancer Models
Supplementary Figure S5 from RNA Interference Using <i>c-Myc</i>–Conjugated Nanoparticles Suppresses Breast and Colorectal Cancer Models Open
Supplementary Figure S5: Biodistribution analysis of nanoparticles using MRI and confocal and live imaging in mammary models
View article: Supplementary Table S1 from RNA Interference Using <i>c-Myc</i>–Conjugated Nanoparticles Suppresses Breast and Colorectal Cancer Models
Supplementary Table S1 from RNA Interference Using <i>c-Myc</i>–Conjugated Nanoparticles Suppresses Breast and Colorectal Cancer Models Open
Supplementary Table S1: Forward and Reverse primers used for quantitative pcr analysis of various genes like c-Myc,p53,GAPDH,NONO and U6
View article: Data from RNA Interference Using <i>c-Myc</i>–Conjugated Nanoparticles Suppresses Breast and Colorectal Cancer Models
Data from RNA Interference Using <i>c-Myc</i>–Conjugated Nanoparticles Suppresses Breast and Colorectal Cancer Models Open
In this article, we report the development and preclinical validation of combinatorial therapy for treatment of cancers using RNA interference (RNAi). RNAi technology is an attractive approach to silence genes responsible for disease onset…
View article: Supplementary Figure S4 from RNA Interference Using <i>c-Myc</i>–Conjugated Nanoparticles Suppresses Breast and Colorectal Cancer Models
Supplementary Figure S4 from RNA Interference Using <i>c-Myc</i>–Conjugated Nanoparticles Suppresses Breast and Colorectal Cancer Models Open
Supplementary Figure S4: Immunoblot analysis of oncoprotein targets using knockdown and mimic probes of microRNAs
View article: Supplementary Figure S6 from RNA Interference Using <i>c-Myc</i>–Conjugated Nanoparticles Suppresses Breast and Colorectal Cancer Models
Supplementary Figure S6 from RNA Interference Using <i>c-Myc</i>–Conjugated Nanoparticles Suppresses Breast and Colorectal Cancer Models Open
Supplementary Figure S6: Densitometric analysis of immunoblots from Figure 2, Figure 3E and Figure 4C.
View article: Supplementary Table S1 from RNA Interference Using <i>c-Myc</i>–Conjugated Nanoparticles Suppresses Breast and Colorectal Cancer Models
Supplementary Table S1 from RNA Interference Using <i>c-Myc</i>–Conjugated Nanoparticles Suppresses Breast and Colorectal Cancer Models Open
Supplementary Table S1: Forward and Reverse primers used for quantitative pcr analysis of various genes like c-Myc,p53,GAPDH,NONO and U6
View article: Supplementary Figure S2: Cytotoxicity assays on different cell lines from RNA Interference Using <i>c-Myc</i>–Conjugated Nanoparticles Suppresses Breast and Colorectal Cancer Models
Supplementary Figure S2: Cytotoxicity assays on different cell lines from RNA Interference Using <i>c-Myc</i>–Conjugated Nanoparticles Suppresses Breast and Colorectal Cancer Models Open
Supplementary Figure S2: Cytotoxicity assays on different cell lines. In vitro cytotoxicity assay
View article: hnRNPA1/UP1 Unfolds <i>KRAS</i> G-Quadruplexes and Feeds a Regulatory Axis Controlling Gene Expression
hnRNPA1/UP1 Unfolds <i>KRAS</i> G-Quadruplexes and Feeds a Regulatory Axis Controlling Gene Expression Open
Recent studies have proven that the genetic landscape of pancreatic cancer is dominated by the KRAS oncogene. Its transcription is controlled by a G-rich motif (called 32R) located immediately upstream of the TSS. 32R may fold into a G-qua…
View article: Structure of two G-quadruplexes in equilibrium in the KRAS promoter
Structure of two G-quadruplexes in equilibrium in the KRAS promoter Open
KRAS is one of the most mutated oncogenes and still considered an undruggable target. An alternative strategy would consist in targeting its gene rather than the protein, specifically the formation of G-quadruplexes (G4) in its promoter. G…
View article: CCDC 1439636: Experimental Crystal Structure Determination
CCDC 1439636: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Design, Synthesis, and Evaluation of 2,9‐Bis[(substituted‐aminomethyl)phenyl]‐1,10‐phenanthroline Derivatives as G‐Quadruplex Ligands
Design, Synthesis, and Evaluation of 2,9‐Bis[(substituted‐aminomethyl)phenyl]‐1,10‐phenanthroline Derivatives as G‐Quadruplex Ligands Open
Genomic sequences able to form guanine quadruplexes (G4) are found in oncogene promoters, in telomeres, and in 5′‐ and 3′‐untranslated regions as well as introns of messenger RNAs. These regions are potential targets for drugs designed to …
View article: G-quadruplexes and helicases
G-quadruplexes and helicases Open
Guanine-rich DNA strands can fold in vitro into non-canonical DNA structures called G-quadruplexes. These structures may be very stable under physiological conditions. Evidence suggests that G-quadruplex structures may act as 'knots' withi…