Anne Bruun Rovsing
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View article: PKP1 promotes lung cancer by modulating energy metabolism through stabilization of PFKP
PKP1 promotes lung cancer by modulating energy metabolism through stabilization of PFKP Open
View article: Multiparametric Optimization of Human Primary B‐Cell Cultures Using Design of Experiments
Multiparametric Optimization of Human Primary B‐Cell Cultures Using Design of Experiments Open
B cells are essential in the immune system, driving antibody production, cytokine secretion and antigen presentation. Studies in mouse models have illuminated key mechanisms underlying B‐cell activation, differentiation, class‐switch recom…
View article: Cell-targeted gene modification by delivery of CRISPR-Cas9 ribonucleoprotein complexes in pseudotyped lentivirus-derived nanoparticles
Cell-targeted gene modification by delivery of CRISPR-Cas9 ribonucleoprotein complexes in pseudotyped lentivirus-derived nanoparticles Open
To fully utilize the potential of CRISPR-Cas9-mediated genome editing, time-restricted and targeted delivery is crucial. By modulating the pseudotype of engineered lentivirus-derived nanoparticles (LVNPs), we demonstrate efficient cell-tar…
View article: Engineered lentivirus-derived nanoparticles (LVNPs) for delivery of CRISPR/Cas ribonucleoprotein complexes supporting base editing, prime editing and <i>in vivo</i> gene modification
Engineered lentivirus-derived nanoparticles (LVNPs) for delivery of CRISPR/Cas ribonucleoprotein complexes supporting base editing, prime editing and <i>in vivo</i> gene modification Open
Implementation of therapeutic in vivo gene editing using CRISPR/Cas relies on potent delivery of gene editing tools. Administration of ribonucleoprotein (RNP) complexes consisting of Cas protein and single guide RNA (sgRNA) offers short-li…
View article: Restriction of C1-inhibitor activity in hereditary angioedema by dominant-negative effects of disease-associated SERPING1 gene variants
Restriction of C1-inhibitor activity in hereditary angioedema by dominant-negative effects of disease-associated SERPING1 gene variants Open
We provide a functional classification of SERPING1 gene variants suggesting that different SERPING1 variants drive the pathogenicity through different and in some cases overlapping molecular disease mechanisms. For a subset of gene variant…
View article: Resistance to vincristine in <scp>DLBCL</scp> by disruption of p53‐induced cell cycle arrest and apoptosis mediated by <scp>KIF18B</scp> and <scp>USP28</scp>
Resistance to vincristine in <span>DLBCL</span> by disruption of p53‐induced cell cycle arrest and apoptosis mediated by <span>KIF18B</span> and <span>USP28</span> Open
Summary The frontline therapy R‐CHOP for patients with diffuse large B‐cell lymphoma (DLBCL) has remained unchanged for two decades despite numerous Phase III clinical trials investigating new alternatives. Multiple large studies have unco…
View article: Resistance to vincristine in cancerous B-cells by disruption of p53-dependent mitotic surveillance
Resistance to vincristine in cancerous B-cells by disruption of p53-dependent mitotic surveillance Open
The frontline therapy R-CHOP for patients with diffuse large B-cell lymphoma (DLBCL) has remained unchanged for two decades despite numerous phase III clinical trials investigating new alternatives. Multiple large studies have uncovered ge…
View article: Identification of BLNK and BTK as mediators of rituximab‐induced programmed cell death by CRISPR screens in GCB‐subtype diffuse large B‐cell lymphoma
Identification of BLNK and BTK as mediators of rituximab‐induced programmed cell death by CRISPR screens in GCB‐subtype diffuse large B‐cell lymphoma Open
Diffuse large B‐cell lymphoma (DLBCL) is characterized by extensive genetic heterogeneity, and this results in unpredictable responses to the current treatment, R‐CHOP, which consists of a cancer drug combination supplemented with the huma…