Anne Dudeck
YOU?
Author Swipe
View article: Ingestion of mast cell granules boosts macrophages and drives atypical programming
Ingestion of mast cell granules boosts macrophages and drives atypical programming Open
MCs enhance the function of macrophages and drive them to atypical polarization through granule-mediated intercellular communication. Our results suggest that beyond acute inflammation, MCs act as important controllers of host defense and …
View article: DNA-binding protein-A promotes kidney ischemia/reperfusion injury and participates in mitochondrial function
DNA-binding protein-A promotes kidney ischemia/reperfusion injury and participates in mitochondrial function Open
DNA-binding protein-A (DbpA; gene: Ybx3) belongs to the cold shock protein family with known functions in cell cycling, transcription, translation, and tight junction communication. In chronic nephritis, DbpA is upregulated. However, its a…
View article: Role of Mast-Cell-Derived RANKL in Ovariectomy-Induced Bone Loss in Mice
Role of Mast-Cell-Derived RANKL in Ovariectomy-Induced Bone Loss in Mice Open
Mast cells may contribute to osteoporosis development, because patients with age-related or post-menopausal osteoporosis exhibit more mast cells in the bone marrow, and mastocytosis patients frequently suffer from osteopenia. We previously…
View article: Mast Cells Drive Systemic Inflammation and Compromised Bone Repair After Trauma
Mast Cells Drive Systemic Inflammation and Compromised Bone Repair After Trauma Open
There is evidence that mast cells contribute to inflammation induced by hemorrhagic shock, severe tissue injury or sepsis. Mast cells are highly responsive to alarm signals generated after trauma, and release many inflammatory mediators in…
View article: ATP/IL‐33‐triggered hyperactivation of mast cells results in an amplified production of pro‐inflammatory cytokines and eicosanoids
ATP/IL‐33‐triggered hyperactivation of mast cells results in an amplified production of pro‐inflammatory cytokines and eicosanoids Open
IL‐33 and ATP are alarmins, which are released upon damage of cellular barriers or are actively secreted upon cell stress. Due to high‐density expression of the IL‐33 receptor T1/ST2 (IL‐33R), and the ATP receptor P2X7, mast cells (MCs) ar…
View article: Metabolic Interdependency of Th2 Cell-Mediated Type 2 Immunity and the Tumor Microenvironment
Metabolic Interdependency of Th2 Cell-Mediated Type 2 Immunity and the Tumor Microenvironment Open
The function of T cells is critically dependent on their ability to generate metabolic building blocks to fulfil energy demands for proliferation and consecutive differentiation into various T helper (Th) cells. Th cells then have to adapt…
View article: Mast Cells in the Skin: Defenders of Integrity or Offenders in Inflammation?
Mast Cells in the Skin: Defenders of Integrity or Offenders in Inflammation? Open
Mast cells (MCs) are best-known as key effector cells of immediate-type allergic reactions that may even culminate in life-threatening anaphylactic shock syndromes. However, strategically positioned at the host–environment interfaces and e…
View article: Mast Cells in the Skin: Defenders of Integrity or Offenders in Inflammation?
Mast Cells in the Skin: Defenders of Integrity or Offenders in Inflammation? Open
Mast cells (MCs) are best known as key effector cells of immediate type allergic reactions that may even culminate in life-threatening anaphylactic shock syndromes. However, strategically positioned at host-environment interfaces and equip…
View article: S-Layer From Lactobacillus brevis Modulates Antigen-Presenting Cell Functions via the Mincle-Syk-Card9 Axis
S-Layer From Lactobacillus brevis Modulates Antigen-Presenting Cell Functions via the Mincle-Syk-Card9 Axis Open
C-type lectin receptors (CLRs) are pattern recognition receptors that are crucial in the innate immune response. The gastrointestinal tract contributes significantly to the maintenance of immune homeostasis; it is the shelter for billions …
View article: Mast Cells Trigger Disturbed Bone Healing in Osteoporotic Mice
Mast Cells Trigger Disturbed Bone Healing in Osteoporotic Mice Open
Mast cells are important tissue-resident sensor and effector immune cells but also play a major role in osteoporosis development. Mast cells are increased in numbers in the bone marrow of postmenopausal osteoporotic patients, and mast cell…
View article: Mast Cell Functions Linking Innate Sensing to Adaptive Immunity
Mast Cell Functions Linking Innate Sensing to Adaptive Immunity Open
Although mast cells (MCs) are known as key drivers of type I allergic reactions, there is increasing evidence for their critical role in host defense. MCs not only play an important role in initiating innate immune responses, but also infl…
View article: Mast Cell Functions Linking Innate Sensing to Adaptive Immunity
Mast Cell Functions Linking Innate Sensing to Adaptive Immunity Open
Although Mast cells are known as key drivers of type I allergic reactions, there is increasing evidence for their critical role in host defense. MCs do not only play an important role in initiating innate immune responses, but also influen…
View article: The Role of Mast Cells in Bone Metabolism and Bone Disorders
The Role of Mast Cells in Bone Metabolism and Bone Disorders Open
Mast cells (MCs) are important sensor and effector cells of the immune system that are involved in many physiological and pathological conditions. Increasing evidence suggests that they also play an important role in bone metabolism and bo…
View article: Mast cells initiate the vascular response to contact allergens by sensing cell stress
Mast cells initiate the vascular response to contact allergens by sensing cell stress Open
Although mast cells (MCs) are well known as key effector cells of IgE-mediated type I allergy, there is growing evidence that MCs are also essential players in innate and adaptive immunity, and in many inflammatory or autoimmune diseases.1…
View article: CD11c-expressing Ly6C+CCR2+ monocytes constitute a reservoir for efficient Leishmania proliferation and cell-to-cell transmission
CD11c-expressing Ly6C+CCR2+ monocytes constitute a reservoir for efficient Leishmania proliferation and cell-to-cell transmission Open
The virulence of intracellular pathogens such as Leishmania major (L. major) relies largely on their ability to undergo cycles of replication within phagocytes, release, and uptake into new host cells. While all these steps are critical fo…
View article: Unimpaired Responses to Vaccination With Protein Antigen Plus Adjuvant in Mice With Kit-Independent Mast Cell Deficiency
Unimpaired Responses to Vaccination With Protein Antigen Plus Adjuvant in Mice With Kit-Independent Mast Cell Deficiency Open
Innate inflammatory responses are crucial for induction and regulation of T cell and antibody responses. Mast cell (MC)-deficient Kit mutant mice showed impaired adaptive immunity, suggesting that MCs provide essential adjuvant activities,…
View article: Mast cells acquire MHCII from dendritic cells during skin inflammation
Mast cells acquire MHCII from dendritic cells during skin inflammation Open
Mast cells (MCs) and dendritic cells (DCs) are essential innate sentinels populating host-environment interfaces. Using longitudinal intravital multiphoton microscopy of DCGFP/MCRFP reporter mice, we herein provide in vivo evidence that mi…
View article: Mast Cells Are Critical Regulators of Bone Fracture–Induced Inflammation and Osteoclast Formation and Activity
Mast Cells Are Critical Regulators of Bone Fracture–Induced Inflammation and Osteoclast Formation and Activity Open
Mast cells, important sensor and effector cells of the immune system, may influence bone metabolism as their number is increased in osteoporotic patients. They are also present during bone fracture healing with currently unknown functions.…
View article: Behavior of Neutrophil Granulocytes during Toxoplasma gondii Infection in the Central Nervous System
Behavior of Neutrophil Granulocytes during Toxoplasma gondii Infection in the Central Nervous System Open
Cerebral toxoplasmosis is characterized by activation of brain resident cells and recruitment of specific immune cell subsets from the periphery to the central nervous system (CNS). Our studies revealed that the rapidly invaded Ly6G+ neutr…