Elizabeth A. Thomas
YOU?
Author Swipe
View article: Efficacy of a peer-delivered group psychological intervention to reduce psychological distress among university students in India: a randomised controlled trial using an active control condition
Efficacy of a peer-delivered group psychological intervention to reduce psychological distress among university students in India: a randomised controlled trial using an active control condition Open
Background: Brief psychological interventions in low-and-middle-income-countries (LMICs) have been typically tested against usual or enhanced usual care (EUC). This design precludes understanding of the role of non-specific factors in infl…
View article: Time-restricted eating and autosomal dominant polycystic kidney disease: a pilot, randomized clinical trial
Time-restricted eating and autosomal dominant polycystic kidney disease: a pilot, randomized clinical trial Open
Background Autosomal dominant polycystic kidney disease (ADPKD) is the most commonly inherited progressive kidney disease. Time-restricted eating (TRE) is a fasting regimen that restricts eating to a particular window (typically 8 hours/da…
View article: The role of specific and non-specific factors in a brief group psychological intervention for psychological distress: a randomised clinical trial
The role of specific and non-specific factors in a brief group psychological intervention for psychological distress: a randomised clinical trial Open
Aims Although brief psychological interventions in low-and-middle-income-countries have been shown to be effective, they have typically been tested against usual or enhanced usual care (EUC). This design has precluded delineation of the ro…
View article: Mapping neurodegeneration across the Huntington's disease spectrum: a five-year longitudinal analysis of plasma neurofilament light
Mapping neurodegeneration across the Huntington's disease spectrum: a five-year longitudinal analysis of plasma neurofilament light Open
NIH (NS111655); the UCSD HDSA CoE; the UCSD ADRC (NIH-NIA P30 AG062429).
View article: The use of accelerometers to improve estimation of the thermic effect of food in whole room calorimetry studies
The use of accelerometers to improve estimation of the thermic effect of food in whole room calorimetry studies Open
Two research-grade accelerometers can effectively estimate spontaneous physical activity and improve the estimation of thermic effect of food (TEF) in whole room calorimeters. The activPAL demonstrates strong group-level accuracy and reaso…
View article: Weight Loss Outcomes in a Veterans Affairs Pharmacotherapy-based Weight Management Clinic
Weight Loss Outcomes in a Veterans Affairs Pharmacotherapy-based Weight Management Clinic Open
Context Despite a high prevalence of obesity in the veteran population, antiobesity medications (AOMs) have been underused in the Veterans Health Administration. Real-world reports on outcomes when AOMs have been used in veterans is limite…
View article: Lithium treatment for affective disorders: Exploring the potential of salivary therapeutic monitoring
Lithium treatment for affective disorders: Exploring the potential of salivary therapeutic monitoring Open
Lithium is one of the most effective medications for treatment-resistant depression and bipolar disorder. However, lithium has a narrow therapeutic window: overdosing can lead to life-threatening lithium intoxication while underdosing resu…
View article: The effects of early time restricted eating plus daily caloric restriction compared to daily caloric restriction alone on continuous glucose levels
The effects of early time restricted eating plus daily caloric restriction compared to daily caloric restriction alone on continuous glucose levels Open
Background The median eating duration in the U.S. is 14.75 h, spread throughout the period of wakefulness and ending before sleep. Food intake at an inappropriate circadian time may lead to adverse metabolic outcomes. Emerging literature s…
View article: An Updated Approach to Antiobesity Pharmacotherapy: Moving Beyond the 5% Weight Loss Goal
An Updated Approach to Antiobesity Pharmacotherapy: Moving Beyond the 5% Weight Loss Goal Open
Despite professional society guidelines recommending that obesity be treated as a chronic disease by emphasizing the use of lifestyle modification in conjunction with pharmacotherapy, antiobesity medications are uncommonly prescribed in mo…
View article: Videoconferencing-delivered psychological intervention for the treatment of COVID-19 related psychological distress in University students: study protocol for a randomised controlled trial in India
Videoconferencing-delivered psychological intervention for the treatment of COVID-19 related psychological distress in University students: study protocol for a randomised controlled trial in India Open
Background The mental health impacts of the COVID-19 pandemic have been profound. This paper outlines the study protocol for a trial that tests the efficacy of a brief group-based psychological intervention ( Coping with COVID; CWC ) , rel…
View article: RF24 | PSUN110 A Cross-Sectional Study Evaluating the Impact of Combined Hormonal Contraceptives on Components of Energy Balance in Pre-Menopausal Women with Overweight or Obesity
RF24 | PSUN110 A Cross-Sectional Study Evaluating the Impact of Combined Hormonal Contraceptives on Components of Energy Balance in Pre-Menopausal Women with Overweight or Obesity Open
Background Combined estrogen and progestin hormonal contraceptives (CHCs, including combined oral contraceptives, hormonal patches, or vaginal rings) expose women to supraphysiologic levels of reproductive hormones, which in turn suppress …
View article: Salivary Huntingtin protein is uniquely associated with clinical features of Huntington’s Disease
Salivary Huntingtin protein is uniquely associated with clinical features of Huntington’s Disease Open
Introduction Measuring Huntingtin (Htt) protein in peripheral cells represents an essential step in biomarker discovery for Huntington’s Disease (HD), however to date, investigations into the salivary expression of Htt has been lacking. Me…
View article: Provider Perspectives on the Current Use of Lithium Medications and Lithium Monitoring Practices for Psychiatric Conditions
Provider Perspectives on the Current Use of Lithium Medications and Lithium Monitoring Practices for Psychiatric Conditions Open
Point-of-care devices and saliva lithium monitoring are promising alternatives to blood testing that would be welcomed by psychiatric societies, however, require extensive development and validation before implementation into a clinical se…
View article: Associations between saliva and plasma cytokines and YKL-40 in cognitively-normal, older adults
Associations between saliva and plasma cytokines and YKL-40 in cognitively-normal, older adults Open
Inflammatory responses play key roles in the development and progression of many pathological conditions, including neurodegenerative conditions. Accurate quantification of inflammatory factors in saliva would be highly advantageous, given…
View article: Early time‐restricted eating compared with daily caloric restriction: A randomized trial in adults with obesity
Early time‐restricted eating compared with daily caloric restriction: A randomized trial in adults with obesity Open
Objective This trial aimed to evaluate the acceptability and efficacy of early time‐restricted eating plus daily caloric restriction (E‐TRE+DCR) compared with DCR alone within a behavioral weight‐loss intervention. Methods Participants ( n…
View article: Salivary S100 calcium-binding protein beta (S100B) and neurofilament light (NfL) after acute exposure to repeated head impacts in collegiate water polo players
Salivary S100 calcium-binding protein beta (S100B) and neurofilament light (NfL) after acute exposure to repeated head impacts in collegiate water polo players Open
Blood-based biomarkers of brain injury may be useful for monitoring brain health in athletes at risk for concussions. Two putative biomarkers of sport-related concussion, neurofilament light (NfL), an axonal structural protein, and S100 ca…
View article: The effects of the COVID‐19 pandemic on weight loss in participants in a behavioral weight‐loss intervention
The effects of the COVID‐19 pandemic on weight loss in participants in a behavioral weight‐loss intervention Open
Objective This study aimed to assess the effects of the COVID‐19 pandemic on weight loss, physical activity, and sleep in adults with overweight or obesity participating in a 39‐week weight‐loss intervention. Methods Participants ( n = 81,…
View article: Saliva testing as a means to monitor therapeutic lithium levels in patients with psychiatric disorders: Identification of clinical and environmental covariates, and their incorporation into a prediction model
Saliva testing as a means to monitor therapeutic lithium levels in patients with psychiatric disorders: Identification of clinical and environmental covariates, and their incorporation into a prediction model Open
Objective The narrow therapeutic window of lithium medications necessitates frequent serum monitoring, which can be expensive and inconvenient for the patient. Compared to blood, saliva collection is easier, non‐invasive, requires less pro…
View article: Improving lifestyle obesity treatment during the COVID‐19 pandemic and beyond: New challenges for weight management
Improving lifestyle obesity treatment during the COVID‐19 pandemic and beyond: New challenges for weight management Open
Objective The COVID‐19 pandemic has resulted in significant changes to daily life and many health‐related behaviors. The objective of this study was to examine how the stay‐at‐home/safer‐at‐home mandates issued in Colorado (March 2020–May …
View article: Plasma neurofilament light in Huntington's disease: A marker for disease onset, but not symptom progression
Plasma neurofilament light in Huntington's disease: A marker for disease onset, but not symptom progression Open
These findings implicate plasma NfL as a peripheral prognostic marker for premanifest-HD. Notably, we show that significant correlations between NfL and clinical symptoms are detected only when PM + HD subjects are combined, but not within…
View article: Saliva testing as a means to monitor therapeutic lithium levels in patients with psychiatric disorders: identification of clinical and environmental covariates, and their incorporation into a prediction model
Saliva testing as a means to monitor therapeutic lithium levels in patients with psychiatric disorders: identification of clinical and environmental covariates, and their incorporation into a prediction model Open
The narrow therapeutic window of lithium medications necessitates frequent serum monitoring, which can be expensive and inconvenient for the patient. The use of saliva as a biofluid may have advantages over blood, as it is non-invasive, ea…
View article: Later Meal and Sleep Timing Predicts Higher Percent Body Fat
Later Meal and Sleep Timing Predicts Higher Percent Body Fat Open
Accumulating evidence suggests that later timing of energy intake (EI) is associated with increased risk of obesity. In this study, 83 individuals with overweight and obesity underwent assessment of a 7-day period of data collection, inclu…
View article: Levels of Interleukin-6 in Saliva, but Not Plasma, Correlate with Clinical Metrics in Huntington’s Disease Patients and Healthy Control Subjects
Levels of Interleukin-6 in Saliva, but Not Plasma, Correlate with Clinical Metrics in Huntington’s Disease Patients and Healthy Control Subjects Open
Growing evidence suggests that inflammatory responses, in both the brain and peripheral tissues, contribute to disease pathology in Huntington’s disease (HD), an inherited, progressive neurodegenerative disorder typically affecting adults …
View article: Uric Acid as a Potential Peripheral Biomarker for Disease Features in Huntington’s Patients
Uric Acid as a Potential Peripheral Biomarker for Disease Features in Huntington’s Patients Open
Oxidative stress has long been implicated in the pathophysiology and progression of Huntington's disease (HD). Uric acid (UA) is a naturally occurring antioxidant that is present in the brain and periphery. Growing evidence has implicated …
View article: Appetite‐Related Responses to Overfeeding and Longitudinal Weight Change in Obesity‐Prone and Obesity‐Resistant Adults
Appetite‐Related Responses to Overfeeding and Longitudinal Weight Change in Obesity‐Prone and Obesity‐Resistant Adults Open
Objective Appetite responses to 3 days of overfeeding (OF) were examined as correlates of longitudinal weight change in adults classified as obesity prone (OP) or obesity resistant (OR). Methods OP ( n = 22) and OR ( n = 30) adults consume…
View article: Evaluation of Biochemical and Epigenetic Measures of Peripheral Brain-Derived Neurotrophic Factor (BDNF) as a Biomarker in Huntington’s Disease Patients
Evaluation of Biochemical and Epigenetic Measures of Peripheral Brain-Derived Neurotrophic Factor (BDNF) as a Biomarker in Huntington’s Disease Patients Open
Huntington's disease (HD) is an autosomal-dominant neurodegenerative movement disorder that presents with prominent cognitive and psychiatric dysfunction. Brain-derived neurotrophic factor (BDNF) plays an important role in the pathophysiol…