Anne E. Wapniarski
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View article: Etiological spectrum of non-compressive myelopathies in Uganda: a prospective, observational study using neuroimaging, autoantibodies, and next-generation sequencing
Etiological spectrum of non-compressive myelopathies in Uganda: a prospective, observational study using neuroimaging, autoantibodies, and next-generation sequencing Open
Background Non-compressive myelopathy can lead to severe disability and death. The diagnosis is often complex and resource-intensive, with regional variation in causes. Data on the epidemiology and etiology of non-compressive myelopathy in…
View article: Etiological Spectrum of Non-Compressive Myelopathies in Uganda: A Prospective, Observational Study Using Neuroimaging, Autoantibodies, and Next-Generation Sequencing
Etiological Spectrum of Non-Compressive Myelopathies in Uganda: A Prospective, Observational Study Using Neuroimaging, Autoantibodies, and Next-Generation Sequencing Open
View article: An autoantibody signature predictive for multiple sclerosis
An autoantibody signature predictive for multiple sclerosis Open
View article: Multiomic Analysis of Neuroinflammation and Occult Infection in Sudden Infant Death Syndrome
Multiomic Analysis of Neuroinflammation and Occult Infection in Sudden Infant Death Syndrome Open
Importance Antemortem infection is a risk factor for sudden infant death syndrome (SIDS)—the leading postneonatal cause of infant mortality in the developed world. Manifestations of infection and inflammation are not always apparent in cli…
View article: A Predictive Autoantibody Signature in Multiple Sclerosis
A Predictive Autoantibody Signature in Multiple Sclerosis Open
Although B cells are implicated in multiple sclerosis (MS) pathophysiology, a predictive or diagnostic autoantibody remains elusive. Here, the Department of Defense Serum Repository (DoDSR), a cohort of over 10 million individuals, was use…
View article: Unbiased serology reveals autoimmunity and HIV antibody signatures in HIV CNS Escape
Unbiased serology reveals autoimmunity and HIV antibody signatures in HIV CNS Escape Open
Background Antiretroviral therapy (ART) suppresses plasma and cerebrospinal fluid (CSF) HIV replication with occasional asymptomatic episodes of detectable HIV RNA known as asymptomatic (AS) escape. Neurosymptomatic (NS) CSF escape is a ra…
View article: Integrating central nervous system metagenomics and host response for diagnosis of tuberculosis meningitis and its mimics
Integrating central nervous system metagenomics and host response for diagnosis of tuberculosis meningitis and its mimics Open
The epidemiology of infectious causes of meningitis in sub-Saharan Africa is not well understood, and a common cause of meningitis in this region, Mycobacterium tuberculosis (TB), is notoriously hard to diagnose. Here we show that integrat…
View article: Meningitis Caused by the Live Varicella Vaccine Virus: Metagenomic Next Generation Sequencing, Immunology Exome Sequencing and Cytokine Multiplex Profiling
Meningitis Caused by the Live Varicella Vaccine Virus: Metagenomic Next Generation Sequencing, Immunology Exome Sequencing and Cytokine Multiplex Profiling Open
Varicella vaccine meningitis is an uncommon delayed adverse event of vaccination. Varicella vaccine meningitis has been diagnosed in 12 children, of whom 3 were immunocompromised. We now report two additional cases of vaccine meningitis in…
View article: Anti–SARS-CoV-2 and Autoantibody Profiles in the Cerebrospinal Fluid of 3 Teenaged Patients With COVID-19 and Subacute Neuropsychiatric Symptoms
Anti–SARS-CoV-2 and Autoantibody Profiles in the Cerebrospinal Fluid of 3 Teenaged Patients With COVID-19 and Subacute Neuropsychiatric Symptoms Open
Pediatric patients with COVID-19 and prominent subacute neuropsychiatric symptoms, ranging from severe anxiety to delusional psychosis, may have anti-SARS-CoV-2 and antineural antibodies in their CSF and may respond to immunotherapy.
View article: Divergent and self-reactive immune responses in the CNS of COVID-19 patients with neurological symptoms
Divergent and self-reactive immune responses in the CNS of COVID-19 patients with neurological symptoms Open
Individuals with coronavirus disease 2019 (COVID-19) frequently develop neurological symptoms, but the biological underpinnings of these phenomena are unknown. Through single-cell RNA sequencing (scRNA-seq) and cytokine analyses of cerebro…